Glycine/sarcosine N-methyltransferase

Glycine/sarcosine N-methyltransferase
Identifiers
EC number 2.1.1.156
CAS number 294210-82-5
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum

Glycine/sarcosine N-methyltransferase (EC 2.1.1.156, ApGSMT, glycine-sarcosine methyltransferase, GSMT, GMT, glycine sarcosine N-methyltransferase, S-adenosyl-L-methionine:sarcosine N-methyltransferase) is an enzyme with systematic name S-adenosyl-L-methionine:glycine(or sarcosine) N-methyltransferase (sarcosine(or N,N-dimethylglycine)-forming).[1][2][3] This enzyme catalyses the following chemical reaction

2 S-adenosyl-L-methionine + glycine \rightleftharpoons 2 S-adenosyl-L-homocysteine + N,N-dimethylglycine (overall reaction)
(1a) S-adenosyl-L-methionine + glycine \rightleftharpoons S-adenosyl-L-homocysteine + sarcosine
(1b) S-adenosyl-L-methionine + sarcosine \rightleftharpoons S-adenosyl-L-homocysteine + N,N-dimethylglycine

This enzyme participates in biosynthesis of betaine from glycine in cyanobacterium Aphanocthece halophytica.

References

  1. Nyyssölä, A., Kerovuo, J., Kaukinen, P., von Weymarn, N. and Reinikainen, T. (2000). "Extreme halophiles synthesize betaine from glycine by methylation". J. Biol. Chem. 275 (29): 22196–22201. doi:10.1074/jbc.M910111199. PMID 10896953.
  2. Nyyssölä, A., Reinikainen, T. and Leisola, M. (2001). "Characterization of glycine sarcosine N-methyltransferase and sarcosine dimethylglycine N-methyltransferase". Appl. Environ. Microbiol. 67 (5): 2044–2050. doi:10.1128/AEM.67.5.2044-2050.2001. PMC 92834. PMID 11319079.
  3. Waditee, R., Tanaka, Y., Aoki, K., Hibino, T., Jikuya, H., Takano, J., Takabe, T. and Takabe, T. (2003). "Isolation and functional characterization of N-methyltransferases that catalyze betaine synthesis from glycine in a halotolerant photosynthetic organism Aphanothece halophytica". J. Biol. Chem. 278 (7): 4932–4942. doi:10.1074/jbc.M210970200. PMID 12466265.

External links

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