List of epidemics

Plague panel with the triumph of death. 1607–35, Deutsches Historisches Museum Berlin

This article is a list of epidemics of infectious disease. Widespread and chronic complaints such as heart disease and allergy are not included if they are not thought to be infectious.

This list is incomplete; you can help by expanding it.

Pre-1500

Death toll (estimate)	Location	Date	Article	Disease	Ref.
75,000–100,000	Greece	429–426 BC	Plague of Athens	unknown, possibly typhus	[1]
5 million; 30% of population	Europe, Western Asia, Northern Africa	165–180	Antonine Plague	unknown, symptoms similar to smallpox	[2]
	Europe	250–266	Plague of Cyprian	unknown, possibly smallpox	[3]
25–50 million; 40% of population	Europe	541–542	Plague of Justinian	plague	[4]
75–100 million; 30–60% of population	Europe	1346–1350	Black Death	plague	[5]

1500–1699

Death toll (estimate)	Location	Date	Article	Disease	Ref.
5–15 million (80% of population)	Mexico	1545–1548	Cocoliztli	viral hemorrhagic fever	[6][7][8]
2–2.5 million (50% of population)	Mexico	1576	Cocoliztli epidemic of 1576	viral hemorrhagic fever	[6][7][8]
	Seneca nation	1592–1596		measles	[9]
	Spain	1596–1602		plague	[10]
	South America	1600–1650		malaria
	England	1603	London	plague
	Egypt	1609		plague
30–90% of population	Southern New England, especially the Wampanoag people	1616–1619		Unknown cause. Latest research suggests epidemic(s) of leptospirosis with Weil syndrome. Classic explanations include yellow fever, bubonic plague, influenza, smallpox, chickenpox, typhus, and syndemic infection of hepatitis B and hepatitis D.	,[11][12]
280,000	Italy	1629–1631	Italian plague of 1629–1631	plague
	Wyandot people	1630	in Ontario	smallpox
	Thirteen Colonies	1633	Plymouth Colony	smallpox
	Thirteen Colonies	1634	Connecticut River area	smallpox
	England	1636	Newcastle	plague
	China	1641–1644	helped end the Ming Dynasty	plague	[13]
	Spain	1647–1652	Great Plague of Seville	plague
	South America	1648		yellow fever
	Italy	1656	Naples	plague
	Thirteen Colonies	1657	Boston, Massachusetts	measles
24,148[14]	Netherlands	1663–1664	Amsterdam	plague
100,000[15]	England	1665–1666	Great Plague of London	plague
40,000	France	1668		plague
	Spain	1676–1685		plague
76,000	Austria	1679	Great Plague of Vienna	plague
	Thirteen Colonies	1687	Boston, Massachusetts	measles
	Thirteen Colonies	1690	New York City	yellow fever

18th century

Death toll (estimate)	Location	Date	Article	Disease	Ref.
	Canada, New France	1702–1703		smallpox	[16]
	Sweden	1710–1711	Stockholm	plague
	Thirteen Colonies	1713	Boston, Massachusetts	measles
	Thirteen Colonies	1713–1715	New England and the Great Lakes	measles
	Canada, New France	1714–1715		measles	[17]
	France	1720–1722	Great Plague of Marseille	plague
	Thirteen Colonies	1721–1722	Boston, Massachusetts	smallpox	[18]
	Thirteen Colonies	1729	Boston, Massachusetts	measles
	Spain	1730	Cadiz	yellow fever
	Thirteen Colonies	1732–1733		influenza	[19]
	Canada, New France	1733		smallpox	[20]
>50,000	Balkans	1738	Great Plague of 1738	plague
	Thirteen Colonies	1738	South Carolina	smallpox
	Thirteen Colonies	1739–1740	Boston, Massachusetts	measles
	Italy	1743	Messina	plague
	Thirteen Colonies	1747	CT, NY, PA, SC	measles
	North America	1755–1756		smallpox
	North America	1759		measles
	North America, West Indies	1761		influenza
	North America, present Day Pittsburgh area.	1763	Native American victims of Biological warfare during the Siege of Fort Pitt, part of the French and Indian War.	Smallpox
>50,000	Russia	1770–1772	Russian plague of 1770–1772	plague
	Pacific Northwest natives	1770s		smallpox	[21]
	North America	1772		measles
	North America	1775	particularly in the northeast	unknown cause
	England	1775–1776		influenza	[22]
	Spain	1778	Cadiz	dengue fever
	Plains Indians	1780–1782	North American smallpox epidemic	smallpox	[23]
	Pueblo Indians	1788		smallpox
	United States	1788	Philadelphia and New York	measles
	New South Wales, Australia	1789–1790	amongst the Aborigines	smallpox	[24]
	United States	1793	Vermont	influenza and epidemic typhus
	United States	1793	Virginia	influenza
	United States	1793–1798	Yellow Fever Epidemic of 1793, resurgences	yellow fever	[25]

19th century

Death toll (estimate)	Location	Date	Article	Disease	Ref.
	Spain	1800–1803		yellow fever	[26]
	Ottoman Empire, Egypt	1801		bubonic plague	[27]
	United States	1803	New York	yellow fever
	Egypt	1812		plague
	Ottoman Empire	1812	Istanbul	plague
	Malta	1813		plague
	Romania	1813	Bucharest	plague
	Ireland	1816–1819		typhus
>>100,000	Asia, Europe	1816–1826	first cholera pandemic	cholera	[28]
	United States	1820–1823	arising near Schuylkill River	fever
	Spain	1821	Barcelona	yellow fever	[29]
	New South Wales, Australia	1828	amongst the Aborigines	smallpox	[30]
	Netherlands	1829	Groningen epidemic	malaria
	South Australia	1829		smallpox	[31]
	Iran	1829–1835		bubonic plague	[32]
>>100,000	Asia, Europe, North America	1829–1851	second cholera pandemic	cholera	[28]
	Egypt	1831		cholera	[33][34]
	Plains Indians	1831–1834		smallpox
	England, France	1832	London, Paris	cholera
	North America	1832	New York City, Montreal other cities	cholera
	United States	1833	Columbus, Ohio	cholera
	United States	1834	New York City	cholera
	Egypt	1834–1836		bubonic plague	[33][34]
	United States	1837	Philadelphia	typhus
	Great Plains	1837–1838	1837-38 smallpox epidemic	smallpox
	Dalmatia	1840		plague
	South Africa	1840	Cape Town	smallpox
	United States	1841	especially severe in the South	yellow fever
20,000+	Canada	1847–1848	Typhus epidemic of 1847	epidemic typhus	[35]
	United States	1847	New Orleans	yellow fever
	worldwide	1847–1848		influenza	[36]
	Egypt	1848		cholera	[33][34]
	North America	1848–1849		cholera
	United States	1850		yellow fever
	North America	1850–1851		influenza
	United States	1851	Illinois, the Great Plains, and Missouri	cholera
	United States	1852	New Orleans	yellow fever
1,000,000	Russia	1852–1860	third cholera pandemic	cholera	[28]
	Ottoman Empire	1853	what is now Yemen	plague	[37]
4,737	Copenhagen, Denmark	1853	Cholera epidemic of Copenhagen 1853	cholera	[38]
616	England	1854	Broad Street cholera outbreak	cholera	[39]
	United States	1855		yellow fever
	worldwide	1855–1950	Third plague pandemic	bubonic plague	[40]
	Portugal	1857	Lisbon	yellow fever
	Victoria, Australia	1857		smallpox	[41]
	Europe, North America, South America	1857–1859		influenza	[42]
	Middle East	1863–1879	fourth cholera pandemic	cholera	[28]
	Egypt	1865		cholera	[33][34]
	Russia, Germany	1866–1867		cholera
	Australia	1867	Sydney	measles
	Iraq	1867		plague	[43]
	Argentina	1852–1871	Buenos Aires	yellow fever	[44]
	Germany	1870–1871		smallpox
40,000	Fiji	1875	Fiji	measles	[45]
	Russian Empire	1877	Baku, now part of Azerbaijan	plague	[46]
	Egypt	1881		cholera	[33][34]
>>9,000	India, Germany	1881–1896	fifth cholera pandemic	cholera	[28]
3,164	Montreal	1885		smallpox	timeline
1,000,000	worldwide	1889–1890	1889–1890 flu pandemic	influenza	[47]

20th century

Death toll (estimate)	Location	Date	Article	Disease	Ref.
	Congo Basin	1896–1906		trypanosomiasis	[48]
>>800,000	Europe, Asia, Africa	1899–1923	sixth cholera pandemic	cholera	[28]
113	San Francisco	1900–1904	Third plague pandemic	bubonic plague	[49]
	West Africa	1900		yellow fever
	Uganda	1900–1920		trypanosomiasis	[50]
	Egypt	1902		cholera	[33][34]
	India	1903		plague	[51]
40,000	China	1910–1912	Harbin, Shenyang	bubonic plague	[52]
75,000,000	worldwide	1918–1920	1918 flu pandemic	influenza	[53]
	Russia	1918–1922		typhus
	Egypt	1942–1944		malaria	[33][34]
	China	1946	Harbin	bubonic plague
	Egypt	1946		relapsing fever	[33][34]
	Egypt	1947		cholera	[33][34]
2,000,000	worldwide	1957–1958	Asian flu	influenza	[54]
	worldwide	1961–present	seventh cholera pandemic	cholera	[28]
1,000,000	worldwide	1968–1969	Hong Kong flu	influenza	[54]
5	Netherlands	1971	Staphorst, Elspeet and Uddel	Poliomyelitis	[55]
35	Yugoslavia	1972	1972 outbreak of smallpox in Yugoslavia	smallpox
	United States	1972–1973	London flu	influenza	[56]
15,000	India	1974	1974 smallpox epidemic of India	smallpox
>30,000,000	Congo Basin	1960–present	HIV/AIDS pandemic	HIV/AIDS	[57]
	South America	1990s		cholera
52	India	1994	1994 plague epidemic in Surat	plague
	West Africa	1996		meningitis

21st century

Death toll (estimate)	Location	Date	Article	Disease	Ref.
	Central America	2000		dengue fever	[58]
	Nigeria	2001		cholera	[59]
	South Africa	2001		cholera	[60]
775	Asia, Canada	2002–2003	SARS	SARS coronavirus
	Algeria	2003		plague	[61]
	Afghanistan	2004		leishmaniasis	[62]
	Bangladesh	2004		cholera	[63]
	Indonesia	2004		dengue fever
	Senegal	2004		cholera	[64]
	Sudan	2004		Ebola
	Mali	2005		yellow fever	[65]
19	Singapore	2005	2005 dengue outbreak in Singapore	dengue fever
	Angola	2006	Luanda	cholera	[66]
	Congo	2006	Ituri Province	plague
	India	2006		malaria	[67]
50+	India	2006	2006 dengue outbreak in India	dengue fever	[68]
	India	2006	Chikungunya outbreaks	Chikungunya virus	[69]
50+	Pakistan	2006	2006 dengue outbreak in Pakistan	dengue fever
	Philippines	2006		dengue fever
	Congo	2007	Mweka	Ebola	[70]
	Ethiopia	2007		cholera	[71]
49	India	2008		cholera	[72]
10	Iraq	2007	2007 Iraq cholera outbreak	cholera	[73]
	Nigeria	2007		Poliomyelitis	[74]
	Puerto Rico, Dominican Republic, Mexico	2007		dengue fever	[75]
	Somalia	2007		cholera	[76]
	Uganda	2007		Ebola
	Vietnam	2007		cholera	[77]
	Brazil	2008		dengue fever
	Cambodia	2008		dengue fever	[78]
	Chad	2008		cholera	[79]
	China	2008		hand, foot and mouth disease
	Madagascar	2008		bubonic plague	[80]
	Philippines	2008		dengue fever	[81]
	Vietnam	2008		cholera	[82]
4,293	Zimbabwe	2008–2009	2008–2009 Zimbabwean cholera outbreak	cholera
18	Bolivia	2009	2009 Bolivian dengue fever epidemic	dengue fever
49	India	2009	2009 Gujarat hepatitis outbreak	hepatitis B
	Queensland, Australia	2009		dengue fever	[83]
	worldwide	2009	Mumps outbreaks in the 2000s	mumps
931	West Africa	2009–2010	2009-2010 West African meningitis outbreak	meningitis	[84]
14,286	worldwide	2009	2009 flu pandemic	influenza	[85][86]
8,500+ (March 2014)	Hispaniola	2010–present	Haiti cholera outbreak	cholera	[87][88]
4,500+ (February 2014)	Congo	2011–present		measles	[89][90]
170	Vietnam	2011–present		hand, foot and mouth disease	[91][92]
350+	Pakistan	2011–present	2011 dengue outbreak in Pakistan	dengue fever
847 (As of 10 January 2013)	Darfur Sudan	2012	2012 yellow fever outbreak in Darfur, Sudan	yellow fever	[93]
449 (As of 11 June 2015)	Worldwide	2012–present	2012 Middle East respiratory syndrome coronavirus outbreak	Middle East respiratory syndrome	[94]
11,300	West Africa	2013–2016	Ebola virus epidemic in West Africa	Ebola virus disease	[95]
183	Americas	2013–2015	2013–14 chikungunya outbreak	Chikungunya	[96]
40	Madagascar	2014–present	2014 Madagascar plague outbreak	Bubonic plague
36	India	2014–present	2014 Odisha jaundice outbreak	primarily Hepatitis E, but also Hepatitis A	[97]
2,035	India	2015–present	2015 Indian swine flu outbreak	Influenza A virus subtype H1N1	[98][99][100]
	Americas	2015–present	Zika virus outbreak in the Americas (2015–present)	Zika virus
Hundreds (as of 1 April 2016)	Africa	2016	2016 yellow fever outbreak in Angola	yellow fever	[101]

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