HBG2

Hemoglobin, gamma G
PDB rendering based on 1fdh.
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 1FDH​, 4MQJ​, 4MQK​
Identifiers
Symbols	HBG2 ; HBG-T1; TNCY
External IDs	OMIM: 142250 HomoloGene: 128032 GeneCards: HBG2 Gene
Gene ontology Molecular function • oxygen transporter activity • iron ion binding • oxygen binding • heme binding Cellular component • cytosol • hemoglobin complex • blood microparticle Biological process • blood coagulation • oxygen transport Sources: Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	3048	15135
Ensembl	ENSG00000196565	ENSMUSG00000052187
UniProt	P69892	P02104
RefSeq (mRNA)	NM_000184	NM_008221
RefSeq (protein)	NP_000175	NP_032247
Location (UCSC)	Chr 11: 5.25 – 5.65 Mb	Chr 7: 103.85 – 103.85 Mb
PubMed search

Hemoglobin subunit gamma-2 is a protein that in humans is encoded by the HBG2 gene.^[1]

Function

The gamma globin genes (HBG1 and HBG2, this gene) are normally expressed in the fetal liver, spleen and bone marrow. Two gamma chains together with two alpha chains constitute fetal hemoglobin (HbF) which is normally replaced by adult hemoglobin (HbA) at birth. In some beta-thalassemias and related conditions, gamma chain production continues into adulthood. The two types of gamma chains differ at residue 136 where glycine is found in the G-gamma product (HBG2) and alanine is found in the A-gamma product (HBG1). The former is predominant at birth. The order of the genes in the beta-globin cluster is: 5' - epsilon – gamma-G – gamma-A – delta – beta - 3'.^[2]

References

1. Higgs DR, Vickers MA, Wilkie AO, Pretorius IM, Jarman AP, Weatherall DJ (May 1989). "A review of the molecular genetics of the human alpha-globin gene cluster". Blood 73 (5): 1081–104. PMID 2649166.
2. "Entrez Gene: HBG2 hemoglobin, gamma G".

Further reading

• Gelinas R, Yagi M, Endlich B, et al. (1985). "Sequences of G gamma, A gamma, and beta genes of the Greek (A gamma) HPFH mutant: evidence for a distal CCAAT box mutation in the A gamma gene.". Prog. Clin. Biol. Res. 191: 125–39. PMID 2413469.
• Anderson NL, Anderson NG (2003). "The human plasma proteome: history, character, and diagnostic prospects.". Mol. Cell Proteomics 1 (11): 845–67. doi:10.1074/mcp.R200007-MCP200. PMID 12488461.