HBQ1

Hemoglobin, theta 1
Identifiers
Symbols	HBQ1 ; HBQ
External IDs	OMIM: 142240 MGI: 3613460 HomoloGene: 3895 GeneCards: HBQ1 Gene
Gene ontology Molecular function • oxygen transporter activity • iron ion binding • protein binding • oxygen binding • heme binding Cellular component • hemoglobin complex Biological process • oxygen transport Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	3049	544763
Ensembl	ENSG00000086506	ENSMUSG00000073063
UniProt	P09105	Q8BYM1
RefSeq (mRNA)	NM_005331	NM_001033981
RefSeq (protein)	NP_005322	NP_001029153
Location (UCSC)	Chr 16: 0.18 – 0.18 Mb	Chr 11: 32.29 – 32.29 Mb
PubMed search

Hemoglobin subunit theta-1 is a protein that in humans is encoded by the HBQ1 gene.^[1][2]

Theta-globin mRNA is found in human fetal erythroid tissue but not in adult erythroid or other nonerythroid tissue. The theta-1 gene may be expressed very early in embryonic life, perhaps sometime before 5 weeks. Theta-1 is a member of the human alpha-globin gene cluster that involves five functional genes and two pseudogenes. The order of genes is: 5' - zeta - pseudozeta - mu - pseudoalpha-1 - alpha-2 - alpha-1 - theta-1 - 3'. Research supports a transcriptionally active role for the gene and a functional role for the peptide in specific cells, possibly those of early erythroid tissue.^[2]

References

1. Higgs DR, Vickers MA, Wilkie AO, Pretorius IM, Jarman AP, Weatherall DJ (May 1989). "A review of the molecular genetics of the human alpha-globin gene cluster". Blood 73 (5): 1081–104. PMID 2649166.
2. "Entrez Gene: HBQ1 hemoglobin, theta 1".

Further reading

• Giardina B, Messana I, Scatena R, Castagnola M (1995). "The multiple functions of hemoglobin.". Crit. Rev. Biochem. Mol. Biol. 30 (3): 165–96. doi:10.3109/10409239509085142. PMID 7555018.
• Kim JH, Yu CY, Bailey A, et al. (1989). "Unique sequence organization and erythroid cell-specific nuclear factor-binding of mammalian theta 1 globin promoters.". Nucleic Acids Res. 17 (14): 5687–700. doi:10.1093/nar/17.14.5687. PMC 318189. PMID 2569721.
• Ley TJ, Maloney KA, Gordon JI, Schwartz AL (1989). "Globin gene expression in erythroid human fetal liver cells.". J. Clin. Invest. 83 (3): 1032–8. doi:10.1172/JCI113944. PMC 303780. PMID 2921315.
• Gonzalez-Redondo JM, Han IS, Gu YC, Huisman TH (1988). "Nucleotide sequence of the human theta 1-globin gene.". Biochem. Genet. 26 (3–4): 207–11. doi:10.1007/BF00561460. PMID 3408475.
• Hsu SL, Marks J, Shaw JP, et al. (1988). "Structure and expression of the human theta 1 globin gene". Nature 331 (6151): 94–6. doi:10.1038/331094a0. PMID 3422341.
• Daniels RJ, Peden JF, Lloyd C, et al. (2001). "Sequence, structure and pathology of the fully annotated terminal 2 Mb of the short arm of human chromosome 16". Hum. Mol. Genet. 10 (4): 339–52. doi:10.1093/hmg/10.4.339. PMID 11157797.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• De Gobbi M, Viprakasit V, Hughes JR, et al. (2006). "A regulatory SNP causes a human genetic disease by creating a new transcriptional promoter". Science 312 (5777): 1215–7. doi:10.1126/science.1126431. PMID 16728641.