HDAC10

Histone deacetylase 10
Identifiers
Symbols	HDAC10 ; HD10
External IDs	OMIM: 608544 MGI: 2158340 HomoloGene: 23749 ChEMBL: 5103 GeneCards: HDAC10 Gene
EC number	3.5.1.98
Gene ontology Molecular function • histone deacetylase activity • protein binding • enzyme binding • NAD-dependent histone deacetylase activity (H3-K14 specific) • protein deacetylase activity • histone deacetylase binding Cellular component • histone deacetylase complex • nucleus • nucleoplasm • cytoplasm Biological process • negative regulation of transcription from RNA polymerase II promoter • chromatin organization • transcription, DNA-templated • regulation of transcription, DNA-templated • protein deacetylation • Notch signaling pathway • oligodendrocyte development • chromatin modification • histone deacetylation • negative regulation of transcription, DNA-templated • histone H3 deacetylation Sources: Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	83933	170787
Ensembl	ENSG00000100429	ENSMUSG00000062906
UniProt	Q969S8	Q6P3E7
RefSeq (mRNA)	NM_001159286	NM_199198
RefSeq (protein)	NP_001152758	NP_954668
Location (UCSC)	Chr 22: 50.25 – 50.25 Mb	Chr 15: 89.12 – 89.13 Mb
PubMed search

Histone deacetylase 10 is an enzyme that in humans is encoded by the HDAC10 gene.^[1][2][3]

Acetylation of histone core particles modulates chromatin structure and gene expression. The opposing enzymatic activities of histone acetyltransferases and histone deacetylases, such as HDAC10, determine the acetylation status of histone tails (Kao et al., 2002).[supplied by OMIM]^[3]

Interactions

HDAC10 has been shown to interact with Histone deacetylase 2^[4] and Nuclear receptor co-repressor 2.^[4]

See also

• Histone deacetylase

References

1. Kao HY, Lee CH, Komarov A, Han CC, Evans RM (Jan 2002). "Isolation and characterization of mammalian HDAC10, a novel histone deacetylase". J Biol Chem 277 (1): 187–93. doi:10.1074/jbc.M108931200. PMID 11677242.
2. Guardiola AR, Yao TP (Jan 2002). "Molecular cloning and characterization of a novel histone deacetylase HDAC10". J Biol Chem 277 (5): 3350–6. doi:10.1074/jbc.M109861200. PMID 11726666.
3. "Entrez Gene: HDAC10 histone deacetylase 10".
4. Fischer, Denise D; Cai Richard; Bhatia Umesh; Asselbergs Fred A M; Song Chuanzheng; Terry Robert; Trogani Nancy; Widmer Roland; Atadja Peter; Cohen Dalia (Feb 2002). "Isolation and characterization of a novel class II histone deacetylase, HDAC10". J. Biol. Chem. (United States) 277 (8): 6656–66. doi:10.1074/jbc.M108055200. ISSN 0021-9258. PMID 11739383.

Further reading

• Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
• Dunham I, Shimizu N, Roe BA, et al. (1999). "The DNA sequence of human chromosome 22". Nature 402 (6761): 489–95. doi:10.1038/990031. PMID 10591208.
• Fischer DD, Cai R, Bhatia U, et al. (2002). "Isolation and characterization of a novel class II histone deacetylase, HDAC10". J. Biol. Chem. 277 (8): 6656–66. doi:10.1074/jbc.M108055200. PMID 11739383.
• Tong JJ, Liu J, Bertos NR, Yang XJ (2002). "Identification of HDAC10, a novel class II human histone deacetylase containing a leucine-rich domain". Nucleic Acids Res. 30 (5): 1114–23. doi:10.1093/nar/30.5.1114. PMC 101247. PMID 11861901.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Rodriguez M, Yu X, Chen J, Songyang Z (2004). "Phosphopeptide binding specificities of BRCA1 COOH-terminal (BRCT) domains". J. Biol. Chem. 278 (52): 52914–8. doi:10.1074/jbc.C300407200. PMID 14578343.
• Hillman RT, Green RE, Brenner SE (2005). "An unappreciated role for RNA surveillance". Genome Biol. 5 (2): R8. doi:10.1186/gb-2004-5-2-r8. PMC 395752. PMID 14759258.
• Osada H, Tatematsu Y, Saito H, et al. (2004). "Reduced expression of class II histone deacetylase genes is associated with poor prognosis in lung cancer patients". Int. J. Cancer 112 (1): 26–32. doi:10.1002/ijc.20395. PMID 15305372.
• Collins JE, Wright CL, Edwards CA, et al. (2005). "A genome annotation-driven approach to cloning the human ORFeome". Genome Biol. 5 (10): R84. doi:10.1186/gb-2004-5-10-r84. PMC 545604. PMID 15461802.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.

External links

• HDAC10 protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.