HLA-A23
| HLA-A23 (MHC Class I, A cell surface antigen) | |||
 | |||
| HLA-A23 | |||
| - | |||
| Protein | transmembrane receptor/ligand | ||
| Structure | αβ heterodimer | ||
| Subunits | HLA-A*2301, β2-microglobulin | ||
| Older names | "HL-A9" | ||
| - | |||
| subtype | allele | Available structures | |
| A23 | *2301 | ||
| Alleles link-out to IMGT/HLA database at EBI | |||
HLA-A23 (A23) is a human leukocyte antigen serotype within HLA-A serotype group. The serotype is determined by the antibody recognition of α23 subset of HLA-A α-chains. For A23, the alpha, "A", chain are encoded by the HLA-A*23 allele group and the β-chain are encoded by B2M locus.[1] This group currently is dominated by A*2301. A23 and A*23 are almost synonymous in meaning.
A23 is a split antigen of the broad antigen HLA-A9 and it is a sister serotype of HLA-A24.
A23 is common in Africa and regions of the Middle East, Mediterranean, and India than Europe, East Asia or the Americas.
Serotype
| A*23 | A23 | A24 | Sample |
| allele | % | % | size (N) |
| *2301 | 95 | 1 | 5119 |
Allele
| Study population |
Freq. (in %)[3] |
|---|---|
| Mali Bandiagara | 22.8 |
| Cameroon Yaounde | 18.7 |
| Senegal Niokholo Mandenka | 17.7 |
| Guinea Bissau | 15.6 |
| Cameroon Bamileke | 14.9 |
| Cape Verde Southeastern I… | 14.8 |
| Cameroon Beti | 13.5 |
| Zimbabwe Harare Shona | 12.7 |
| USA African America | 11.1 |
| Portugal North | 10.9 |
| South African Natal Zulu | 10.0 |
| Cuban Mulatto | 9.5 |
| Tunisia | 9.4 |
| Kenya Luo | 8.9 |
| Morocco Berber Nador Meta… | 8.2 |
| Zambia Lusaka | 8.1 |
| China Beijing | 7.5 |
| Kenya Nandi | 7.1 |
| Uganda Kampala | 6.8 |
| Georgia Tibilisi Kurds | 6.7 |
| Portugal South | 6.1 |
| Sudanese | 5.8 |
| Bulgaria | 5.5 |
| Israel Arab Druse | 5.5 |
| Saudi Arabia Guraiat and … | 5.4 |
| Spain Catalonia Girona | 4.6 |
| Kenya | 4.5 |
| Venezuela Caracus | 4.0 |
| USA South Texas Hispanics | 3.9 |
| Mexico Mestizos | 3.7 |
| Russia Tuva pop 2 | 2.9 |
| Romanian | 2.5 |
| Croatia | 2.3 |
| Brazil | 2.0 |
| Spain Basque Gipuzkoa Pro… | 2.0 |
| Australia New South Wales | 1.9 |
| Czech Republic | 1.9 |
| Georgia Tibilisi Georgian… | 1.9 |
| Oman | 1.7 |
| Belgium | 1.6 |
| USA North American Native… | 1.6 |
| China Inner Mongolia | 1.5 |
| India New Delhi | 1.5 |
| Pakistan Pathan | 1.5 |
| Ireland Northern | 1.4 |
| Jordan Amman | 1.4 |
| Mongolia Buriat | 1.4 |
| Pakistan Sindhi | 1.3 |
| USA Caucasian (2) | 1.3 |
| France South East | 1.2 |
| Italy North Pavia | 1.2 |
| Iran Baloch | 1.1 |
| Italy Bergamo | 1.1 |
| France Corsica | 1.0 |
| India North Hindus | 1.0 |
| Portugal Centre | 1.0 |
| Allele frequencies presented, only | |
Haplotypes
A23-B7 is found in N.Afr. and S.Afr non-caucasians.
A23-B44 is found in Albania, Zimbabwe, Morocco, Spain and Danes.
A23-B58 is found in the !kung and Zaire.
Associated diseases
A*23:Cw*07 is associated with higher viral load in HIV[4]
References
- ↑ Arce-Gomez B, Jones EA, Barnstable CJ, Solomon E, Bodmer WF (February 1978). "The genetic control of HLA-A and B antigens in somatic cell hybrids: requirement for beta2 microglobulin". Tissue Antigens 11 (2): 96–112. doi:10.1111/j.1399-0039.1978.tb01233.x. PMID 77067.
- ↑ Allele Query Form IMGT/HLA - European Bioinformatics Institute
- ↑ Middleton D, Menchaca L, Rood H, Komerofsky R (2003). "New allele frequency database: http://www.allelefrequencies.net". Tissue Antigens 61 (5): 403–7. doi:10.1034/j.1399-0039.2003.00062.x. PMID 12753660.
- ↑ Tang J, Tang S, Lobashevsky E, Myracle A, Fideli U, Aldrovandi G, Allen S, Musonda R, Kaslow R (2002). "Favorable and unfavorable HLA class I alleles and haplotypes in Zambians predominantly infected with clade C human immunodeficiency virus type 1.". J Virol 76 (16): 8276–84. doi:10.1128/JVI.76.16.8276-8284.2002. PMC 155130. PMID 12134033.