HLA-A26
HLA-A26 (MHC Class I, A cell surface antigen) | |||
HLA-A26 | |||
- | |||
Protein | transmembrane receptor/ligand | ||
Structure | αβ heterodimer | ||
Subunits | HLA-A*2601, β2-microglobulin | ||
Older names | "A10" | ||
- | |||
subtype | allele | Available structures | |
A26.1 | *2601 | ||
rare alleles | |||
A26.2 | *2602 | ||
A26.4 | *2603 | ||
- | *2605 | ||
Alleles link-out to IMGT/HLA database at EBI |
HLA-A26 (A26) is a human leukocyte antigen serotype within HLA-A serotype group. The serotype is determined by the antibody recognition of α26 subset of HLA-A α-chains. For A26, the alpha "A" chain are encoded by the HLA-A*26 allele group and the β-chain are encoded by B2M locus.[1] This group currently is dominated by A*2601. A26 and A*26 are almost synonymous in meaning. A26 is a split antigen of the broad antigen serotype A10. A26 is a sister serotype of A25, A34, A43, and A66.
Further information: HLA serotypes explained
A26 is more common in West Pacific Rim (Taiwan to Hokkaido).
Serotype
A*26 | A26 | A10 | Sample |
allele | % | % | size (N) |
*2601 | 97 | 2 | 1730 |
*2602 | 81 | 0 | 31 |
*2603 | 68 | 8 | 38 |
*2605 | 90 | 0 | 10 |
A26 reasonably good serotyping with no overt false recognition..
Distribution
Study population |
Freq. (in %)[3] |
---|---|
Taiwan Taroko | 21.8 |
Taiwan Bunun | 19.3 |
Japan Ainu Hokkaido | 17.0 |
Taiwan Rukai | 14.0 |
USA Hawaii Okinawa | 12.4 |
Georgia Tibilisi Kurds | 11.7 |
Pakistan Baloch | 10.3 |
Oman | 10.2 |
Pakistan Burusho | 9.8 |
Pakistan Karachi Parsi | 8.3 |
China Beijing | 8.2 |
Pakistan Sindhi | 8.2 |
Japan Central | 8.1 |
Pakistan Brahui | 8.0 |
Taiwan Atayal | 8.0 |
India New Delhi | 7.6 |
Bulgaria | 7.3 |
PNG New Britain Rabaul | 7.3 |
Taiwan Hakka | 6.4 |
Georgia Svaneti Svans | 6.3 |
Pakistan Pathan | 6.1 |
American Samoa | 6.0 |
South Korea (3) | 6.0 |
Israel Arab Druse | 5.5 |
Croatia | 5.3 |
Taiwan Saisiat | 4.9 |
Taiwan Tsou | 4.9 |
Cape Verde Northwestern I… | 4.8 |
China Tibetan | 4.7 |
China Qinghai Hui | 4.5 |
Iran Baloch | 4.5 |
Russia Tuva (2) | 4.5 |
France South East | 4.3 |
Portugal North | 4.3 |
Senegal Niokholo Mandenka | 4.3 |
USA Caucasian (2) | 4.2 |
India Andhra Pradesh Goll… | 4.0 |
Taiwan Paiwan | 3.9 |
USA Hispanic | 3.9 |
Romanian | 3.8 |
Jordan Amman | 3.5 |
Saudi Arabia Guraiat and … | 3.5 |
China Inner Mongolia | 3.4 |
Georgia Tibilisi Georgian… | 3.3 |
USA Asian | 3.2 |
Guinea Bissau | 3.1 |
Ireland South | 3.0 |
Singapore Javanese Indone… | 3.0 |
Taiwan Puyuma | 3.0 |
Czech Republic | 2.8 |
Taiwan Pazeh | 2.7 |
Brazil | 2.5 |
PNG Madang | 2.5 |
Mexico Guadalajara Mestiz… | 2.4 |
Mexico Mestizos | 2.4 |
Singapore Chinese Han | 2.3 |
Australia New South Wales | 2.2 |
China Yunnan Lisu | 2.2 |
Burkina Faso Rimaibe | 2.1 |
Cameroon Beti | 2.0 |
China Guangzhou | 2.0 |
Portugal South | 2.0 |
Singapore Riau Malay | 2.0 |
South Africa Natal Tamil | 2.0 |
Taiwan Siraya | 2.0 |
USA African Americans (2) | 2.0 |
India North Hindus | 1.9 |
Ireland Northern | 1.8 |
Sudanese | 1.8 |
Cameroon Yaounde | 1.7 |
India North Delhi | 1.7 |
Pakistan Kalash | 1.7 |
Taiwan Thao | 1.7 |
China South Han | 1.6 |
USA North American Native… | 1.6 |
Zimbabwe Harare Shona | 1.6 |
Uganda Kampala | 1.5 |
Mongolia Buriat | 1.4 |
Thailand | 1.4 |
New Caledonia | 1.2 |
Zambia Lusaka | 1.2 |
Finland | 1.1 |
Ch. Guangdong Meizhou H… | 1.0 |
Allele frequencies presented, only |
Study population |
Freq. (in %)[3] |
---|---|
Japan Central | 2.3 |
USA North American Native… | 1.6 |
Japan (5) | 1.3 |
Japan Okinawa Ryukyuan | 1.1 |
Pakistan Brahui | 0.6 |
South Korea (3) | 0.6 |
USA San Antonio Caucasian… | 0.6 |
Azores Terceira Island | 0.4 |
USA Asian | 0.4 |
Beijing Shijiazhuang Tian… | 0.1 |
Allele frequencies presented, only |
Study population |
Freq. (in %)[3] |
---|---|
USA Hawaii Okinawa | 8.6 |
Japan Okinawa Ryukyuan | 2.8 |
Japan Central | 2.4 |
Japan Ainu Hokkaido | 2.0 |
Japan (5) | 1.3 |
India North Delhi | 1.1 |
South Korea (3) | 1.0 |
Spain Basque Gipuzkoa Pro… | 0.5 |
China Tibetan | 0.3 |
Romanian | 0.3 |
USA African Americans pop… | 0.3 |
Allele frequencies presented, only |
Disease associations
A26 Serotype is associated with adult T-cell leukemia in Japanese.[4][5]
References
- ↑ Arce-Gomez B, Jones EA, Barnstable CJ, Solomon E, Bodmer WF (February 1978). "The genetic control of HLA-A and B antigens in somatic cell hybrids: requirement for beta2 microglobulin". Tissue Antigens 11 (2): 96–112. doi:10.1111/j.1399-0039.1978.tb01233.x. PMID 77067.
- ↑ Allele Query Form IMGT/HLA - European Bioinformatics Institute
- 1 2 3 Middleton D, Menchaca L, Rood H, Komerofsky R (2003). "New allele frequency database: http://www.allelefrequencies.net". Tissue Antigens 61 (5): 403–7. doi:10.1034/j.1399-0039.2003.00062.x. PMID 12753660.
- ↑ Nomura K, Utsunomiya A, Furushou H, Tara M, Hazeki M, Tokunaga M, Uozumi K, Hanada S, Yashiki S, Tajima K, Sonoda S (2006). "A family predisposition to adult T-cell leukemia.". J Clin Exp Hematop 46 (2): 67–71. doi:10.3960/jslrt.46.67. PMID 17142956.
- ↑ Yashiki S, Fujiyoshi T, Arima N, Osame M, Yoshinaga M, Nagata Y, Tara M, Nomura K, Utsunomiya A, Hanada S, Tajima K, Sonoda S (2001). "HLA-A*26, HLA-B*4002, HLA-B*4006, and HLA-B*4801 alleles predispose to adult T cell leukemia: the limited recognition of HTLV type 1 tax peptide anchor motifs and epitopes to generate anti-HTLV type 1 tax CD8(+) cytotoxic T lymphocytes.". AIDS Res Hum Retroviruses 17 (11): 1047–61. doi:10.1089/088922201300343735. PMID 11485622.
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