HLA-Cw7

HLA-Cw7 (MHC Class I, C cell surface antigen)
-
Protein	transmembrane receptor/ligand
Structure	αβ heterodimer
Subunits	HLA-Cw*07--, β2-microglobulin
Older names	"-"
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subtype	allele	Available structures
Cw7	*0701
-	*0702
Alleles link-out to IMGT/HLA database at EBI

HLA-Cw7 (Cw7) is a human leukocyte antigen serotype within HLA-C serotype group. (For more general information on HLA serotypes, please see the article: History and naming of human leukocyte antigens.) Cw7 is determined by the antibody recognition of α⁷ subset of HLA-Cw α-chains. For the serotype Cw7, the alpha chain are encoded by the HLA-Cw*07 allele group and the β-chain are encoded by B2M locus.^[1] Cw7 and Cw*07 are almost synonymous in meaning. Cw7 is more common in West Africa to Ireland. Cw7 in Europe is part of the AH8.1 and HLA B7-DR15-DQ6 haplotypes. The class I region of these supertype is HLA A1-B8 haplotype, HLA A3-B7, HLA-A2-B7 and HLA A24-B7.

Serotype

Cw7 recognition of some HLA Cw*07 gene products^[2]

Cw*07	Cw7	Sample
allele	%	size (N)
*0701	74	304
*0702	68	976

Distribution

HLA Cw*0701 frequencies

Study population	Freq.  (in %)[3]
Cameroon Pygmy Baka	25.0
Ireland South	21.2
German Essen	20.9
Cameroon Sawa	19.2
Ireland Northern	18.7
France West	18.1
Kenya	17.8
Burkina Faso Fulani	17.4
Australia New South Wales	17.3
France South East	17.3
Morocco 'Berber' Nador Me…	16.7
Sudanese	16.5
United Kingdom Caucasians	16.1
Uganda Kampala	16.0
Brazil	15.6
USA Caucasian (2)	15.5
Kenya Nandi	15.2
Pakistan Baloch	15.2
Burkina Faso Rimaibe	14.9
Finland	14.4
Czech Republic	14.2
Swiss Geneva	13.6
South Africa Natal Tamil	13.5
Cameroon Bamileke	13.0
India Khandesh Pawra	13.0
Cameroon Beti	12.9
Tunisia	12.6
India New Delhi	12.5
Saudi Arabia Guraiat and …	12.3
Turkey	12.3
Zambia Lusaka	12.2
Kenya Luo	11.7
Burkina Faso Mossi	11.3
South Korea (1)	11.1
Spain Eastern Andalusia	11.0
USA Hispanic	10.9
Lebanon	10.8
India Tamil Nadu Nadar	10.7
Zimbabwe Harare Shona	10.6
Russia Arkhangelsk Pomors	10.0
Georgia Tibilisi Georgian…	9.8
Mexico Zaptotec Oaxaca	9.7
Israel Arab Druse	9.0
Senegal Niokholo Mandenka	8.7
USA North American Native…	8.6
Pakistan Sindhi	8.3
India North Delhi	8.0
Iran Baloch	7.8
Thailand	7.7
Singapore Riau Malay	7.5
India West Coast Parsis	7.0
Georgia Tibilisi Kurds	6.9
Pakistan Kalash	6.5
Mali Bandiagara	6.2
Pakistan Burusho	5.6
Pakistan Karachi Parsi	5.5
Pakistan Pathan	5.5
Russia Murmansk Saomi	4.0
Singapore Javanese Indone…	4.0
India Mumbai Marathas	3.7
Australia Indig. Cape Yor…	3.4
Pakistan Brahui	3.4
India West Bhils	3.0
China North Han	2.9
Jordan Amman	2.8
China Inner Mongolia	2.5
Italy North Pavia	2.5
Russia Nenets	2.4
China Qinghai Hui	2.3
Australia Indig. Groote E…	2.1
Russia Tuva (2)	2.0
USA Hawaii Okinawa	1.9
USA Asian	1.8
China South Han	1.6
China Beijing	1.5
Papua New Guinea Wanigela	1.4
Allele frequencies presented, only

HLA Cw*0702 frequencies

Study population	Freq.  (in %)[3]
Venezuela Sierra de Perij…	71.4
PNG New Britain Rabaul	57.1
Mexico Mixtec Oaxaca	33.3
China Yunnan Lisu	32.9
Taiwan Taroko	31.8
China Yunnan Nu	30.7
Venezuela Perja Mountain …	30.3
PNG Madang	30.2
Mexico Zaptotec Oaxaca	28.4
Taiwan Tsou	27.5
Mexico Mixe Oaxaca	26.4
Russia Arkhangelsk Pomors	26.0
Ch. Guangdong Meizhou H…	25.8
Pakistan Burusho	25.5
USA South Dakota Lakota S…	24.4
Russia Nenets	23.8
USA New Mexico Canoncito …	23.2
China South Han	20.8
Brazil Terena	20.2
China Guangzhou	19.9
USA Asian	19.5
Ireland Northern	18.6
Swiss Geneva	18.2
Taiwan Bunun	17.8
Ireland South	17.4
Singapore Javanese Indone…	17.0
Philippines Ivatan	16.0
Taiwan Rukai	16.0
Australia New South Wales	15.8
Finland	15.6
USA South Texas Hispanics	15.6
Pakistan Sindhi	15.5
United Kingdom Caucasians	15.5
Saudi Arabia Guraiat and …	15.2
Cameroon Pygmy Baka	15.0
India Tamil Nadu Nadar	14.8
Japan Central	14.6
Russia Murmansk Saomi	14.0
USA Hawaii Okinawa	13.8
China Beijing	13.6
China Tibetan	13.3
China Qinghai Hui	13.2
Thailand	13.0
USA North American Native…	12.8
China Inner Mongolia	12.7
Japan (3)	12.7
Pakistan Brahui	12.5
PNG Wanigela	12.5
USA Caucasian pop2	12.5
USA Hispanic	12.4
Czech Republic	12.3
China North Han	11.9
Taiwan Paiwan	11.8
China Wuhan	11.6
Cameroon Sawa	11.5
Taiwan Siraya	10.8
Taiwan Ami	10.7
New Caledonia	10.0
India North Delhi	9.9
Australia Indig. Cape Yor…	9.6
Pakistan Pathan	9.5
France West	9.4
Iran Baloch	9.4
South Africa Natal Tamil	9.4
German Essen	9.1
Taiwan Puyuma	9.0
India New Delhi	8.9
Pakistan Kalash	8.7
India Mumbai Marathas	8.6
Russia Tuva pop 2	8.6
South Korea (3)	8.3
American Samoa	8.0
Brazil	8.0
USA African American	8.0
France South East	7.2
Cameroon Bamileke	7.1
India West Bhils	7.0
Australia Indig. Yuendumu	6.8
Cameroon Beti	6.6
Georgia Tibilisi Georgian…	6.5
Uganda Kampala	6.1
Turkey	6.0
Spain Eastern Andalusia	5.5
PNG Wosera	5.4
Mali Bandiagara	4.7
Zimbabwe Harare Shona	4.6
Mexico Chihuahua State Ta…	4.5
Pakistan Baloch	4.5
Kenya	4.4
Zambia Lusaka	4.4
Lebanon	4.1
Israel Arab Druse	4.0
Kenya Luo	3.8
Tunisia	3.6
PNG Eastern Highlands Gor…	3.5
Sudanese	3.5
Georgia Tibilisi Kurds	3.4
Morocco 'Berber' Nador Me…	3.2
England London Ashkenazi …	2.9
Allele frequencies presented, only

References

1. Arce-Gomez B, Jones EA, Barnstable CJ, Solomon E, Bodmer WF (February 1978). "The genetic control of HLA-A and B antigens in somatic cell hybrids: requirement for beta2 microglobulin". Tissue Antigens 11 (2): 96–112. doi:10.1111/j.1399-0039.1978.tb01233.x. PMID 77067.
2. Allele Query Form IMGT/HLA - European Bioinformatics Institute
3. Middleton D, Menchaca L, Rood H, Komerofsky R (2003). "New allele frequency database: http://www.allelefrequencies.net". Tissue Antigens 61 (5): 403–7. doi:10.1034/j.1399-0039.2003.00062.x. PMID 12753660.