Haplogroup I (mtDNA)

Haplogroup I
Possible time of origin 20,857 ± 3,594 Before Present (Behar 2012b)
Possible place of origin West Asia (Terreros 2011 and Fernandes 2012)
Ancestor N1e'I
Descendants I1, I2'3, I4, I5, I6
Defining mutations T10034C, G16129A!, G16391A (Behar & Family Tree DNA 2012)

Haplogroup I is a human mitochondrial DNA (mtDNA) haplogroup. It is largely distributed in Northeast Africa, Europe and West Asia. The latter area is believed to be the clade's place of origin.

Origin

Haplogroup I is a descendant (subclade) of haplogroup N1e'I (Behar 2012b) and sibling of haplogroup N1e (Behar 2012b). It is believed to have arisen somewhere in West Asia between 17,263 and 24,451 years before present (Behar 2012b). It has been suggested that its origin may be in Iran or more generally the Near East (Terreros 2011).

It is noteworthy that, with the exception of its northern neighbor Azerbaijan, Iran is the only population in which haplogroup I exhibits polymorphic levels. Also, a contour plot based on the regional phylogeographic distribution of the I haplogroup exhibits frequency clines consistent with an Iranian cradle... Moreover, when compared with other populations in the region, those from the Levant (Iraq, Syria and Palestine) and the Arabian Peninsula (Oman and UAE) exhibit significantly lower proportions of I individuals... It should be noted that this haplogroup has been detected in European groups (Krk, a tiny island off the coast of Croatia (11.3%), and Lemko, an isolate from the Carpathian Highlands (11.3%)) at comparable frequencies to those observed in the North Iranian population. However, the higher frequencies of the haplogroup within Europe are found in geographical isolates and are likely the result of founder effects and/or drift... it is plausible that the high levels of haplogroup I present in Iran may be the result of a localized enrichment through the action of genetic drift or may signal geographical proximity to the location of origin.

Terreros 2011

A similar view puts more emphasis on the Persian Gulf region of the Near East (Fernandes 2012).

Haplogroup I ... dates to ∼25 ka ago and is overall most frequent in Europe..., but the facts that it has a frequency peak in the Gulf region and that its highest diversity values are in the Gulf, Anatolia, and southeast Europe suggest that its origin is most likely in the Near East and/or Arabia...

Fernandes 2012

Distribution

Haplogroup I is found at moderate to low frequencies in East Africa, Europe, West Asia and South Asia (Fernandes 2012). The rare basal/paraphyletic clade I* has been observed in three individuals; two from Somalia and one from Iran (Olivieri 2013).

Africa

Outside of Europe, the highest frequencies of mitochondrial haplogroup I observed so far appear in the Cushitic-speaking El Molo (23%) and Rendille (>17%) in northern Kenya (Castrì 2008). The clade is also found at comparable frequencies among the Socotri (~22%).[1]

Population Location Language Family N Frequency Source
AmharaEthiopiaAfro-Asiatic > Semitic1/1200.83%Kivisild 2004
EgyptiansEgyptAfro-Asiatic > Semitic2/345.9%Stevanovitch 2004
Beta IsraelEthiopiaAfro-Asiatic > Cushitic0/290.00%Behar 2008a
Dawro KontaEthiopiaAfro-Asiatic > Omotic0/1370.00%Castrì 2008 and Boattini 2013
EthiopiaEthiopiaUndetermined0/770.00%Soares 2011
Ethiopian JewsEthiopiaAfro-Asiatic > Cushitic0/410.00%Non 2011
GurageEthiopiaAfro-Asiatic > Semitic1/214.76%Kivisild 2004
HamerEthiopiaAfro-Asiatic > Omotic 0/110.00%Castrì 2008 and Boattini 2013
OngotaEthiopiaAfro-Asiatic > Cushitic0/190.00%Castrì 2008 and Boattini 2013
OromoEthiopiaAfro-Asiatic > Cushitic0/330.00%Kivisild 2004
TigraiEthiopiaAfro-Asiatic > Semitic0/440.00%Kivisild 2004
DaasanachKenyaAfro-Asiatic > Cushitic0/490.00%Poloni 2009
ElmoloKenyaAfro-Asiatic > Cushitic12/5223.08%Castrì 2008 and Boattini 2013
LuoKenyaNilo-Saharan0/490.00%Castrì 2008 and Boattini 2013
MaasaiKenyaNilo-Saharan0/810.00%Castrì 2008 and Boattini 2013
NairobiKenyaNiger-Congo0/1000.00%Brandstatter 2004
NyangatomKenyaNilo-Saharan1/1120.89%Poloni 2009
RendilleKenyaAfro-Asiatic > Cushitic3/1717.65%Castrì 2008 and Boattini 2013
SamburuKenyaNilo-Saharan3/358.57%Castrì 2008 and Boattini 2013
TurkanaKenyaNilo-Saharan0/510.00%Castrì 2008 and Boattini 2013
HutuRwandaNiger-Congo0/420.00%Castrì 2009
DinkaSudanNilo-Saharan0/460.00%Krings 1999
SudanSudanUndetermined0/1020.00%Soares 2011
BurungeTanzaniaAfro-Asiatic > Cushitic1/382.63%Tishkoff 2007
DatogaTanzaniaNilo-Saharan0/570.00%Tishkoff 2007 and Knight 2003
IraqwTanzaniaAfro-Asiatic > Cushitic0/120.00%Knight 2003
SukumaTanzaniaNiger-Congo0/320.00%Tishkoff 2007 and Knight 2003
TuruTanzaniaNiger-Congo0/290.00%Tishkoff 2007
YemeniYemenAfro-Asiatic > Semitic0/1140.00%Kivisild 2004

Asia

Haplogroup I is present across West Asia and Central Asia, and is also found at trace frequencies in South Asia. Its highest frequency area is perhaps in northern Iran (9.7%). Terreros 2011 notes that it also has high diversity there and reiterates past studies that have suggested that this may be its place of origin. Found in Svan population from Georgia(Caucasus) I* 4.2%."Sequence polymorphisms of the mtDNA control region in a human isolate: the Georgians from Swanetia."Alfonso-Sánchez MA1, Martínez-Bouzas C, Castro A, Peña JA, Fernández-Fernández I, Herrera RJ, de Pancorbo MM. The table below shows some of the populations where it has been detected.

Population Language Family N Frequency Source
BaluchIndo-European0/390.00%Quintana-Murci 2004
BrahuiDravidian0/380.00%Quintana-Murci 2004
Caucasus (Georgia)*Caucasian1/581.80%Quintana-Murci 2004
Druze-11/3113.54%Shlush 2008
GilakiIndo-European0/370.00%Quintana-Murci 2004
GujaratiIndo-European0/340.00%Quintana-Murci 2004
HazaraIndo-European0/230.00%Quintana-Murci 2004
Hunza BurushoIsolate2/444.50%Quintana-Murci 2004
India-8/25440.30%Metspalu 2004
Iran (North)-3/319.70%Terreros 2011
Iran (South)-2/1171.70%Terreros 2011
KalashIndo-European0/440.00%Quintana-Murci 2004
Kurdish (Western Iran)Indo-European1/205.00%Quintana-Murci 2004
Kurdish (Turkmenistan)Indo-European1/323.10%Quintana-Murci 2004
LurIndo-European0/170.00%Quintana-Murci 2004
MakraniIndo-European0/330.00%Quintana-Murci 2004
MazandarianIndo-European1/214.80%Quintana-Murci 2004
PakistaniIndo-European0/1000.00%Quintana-Murci 2004
Pakistan-1/1450.69%Metspalu 2004
ParsiIndo-European0/440.00%Quintana-Murci 2004
PathanIndo-European1/442.30%Quintana-Murci 2004
PersianIndo-European1/422.40%Quintana-Murci 2004
ShugnanIndo-European1/442.30%Quintana-Murci 2004
SindhiIndo-European1/238.70%Quintana-Murci 2004
Turkish (Azerbaijan)Altaic2/405.00%Quintana-Murci 2004
Turkish (Anatolia)*Altaic1/502.00%Quintana-Murci 2004
TurkmenAltaic0/410.00%Quintana-Murci 2004
UzbekAltaic0/420.00%Quintana-Murci 2004

Europe

Western Europe

In Western Europe, haplogroup I is most common in Northwestern Europe (Norway, the Isle of Skye, and the British Isles). The frequency in these areas is between 2 and 5 percent. Its highest frequency in Brittany, France where it is over 9 percent of the population in Finistere. It is uncommon and sometimes absent in other parts of Western Europe (Iberia, South-West France, and parts of Italy).

Population Language N Frequency Source
Austria/Switzerland-4/1872.14%Helgason 2001
Basque (Admix Zone)Basque/Labourdin côtier-haut navarrais0/560.00%Martınez-Cruz 2012
Basque (Araba)Basque/Occidental0/550.00%Martınez-Cruz 2012
Basque (Bizkaia)Basque/Biscayen1/591.69%Martınez-Cruz 2012
Basque (Central/Western Navarre )Basque/Haut-navarrais méridional2/633.17%Martınez-Cruz 2012
Basque (Gipuskoa)Basque/Gipuzkoan0/570.00%Martınez-Cruz 2012
Basque (Navarre Labourdin)Basque/Bas-navarrais0/680.00%Martınez-Cruz 2012
Basque (North/Western Navarre)Basque/Haut-navarrais septentrional0/510.00%Martınez-Cruz 2012
Basque (Roncal)Basque/Roncalais-salazarais0/550.00%Martınez-Cruz 2012
Basque (Soule)Basque/Souletin0/620.00%Martınez-Cruz 2012
Basque (South/Western Gipuskoa)Basque/Biscayen0/640.00%Martınez-Cruz 2012
BéarnFrench0/510.00%Martınez-Cruz 2012
BigorreFrench0/440.00%Martınez-Cruz 2012
BurgosSpanish0/250.00%Martınez-Cruz 2012
CantabriaSpanish0/180.00%Martınez-Cruz 2012
ChalosseFrench0/580.00%Martınez-Cruz 2012
Denmark-6/1055.71%Mikkelsen 2010
England/Wales-12/4293.03%Helgason 2001
Finland-1/492.04%Torroni 1996
Finland/Estonia-5/2022.48%Helgason 2001
France (Finistere)-2/229.10%Dubut 2003
France (Morbihan)-0/400.00%Dubut 2003
France (Normandy)-0/390.00%Dubut 2003
France (Périgord-Limousin)-2/722.80%Dubut 2003
France (Var)-2/375.40%Dubut 2003
France/Italy-2/2480.81%Helgason 2001
Germany-12/5272.28%Helgason 2001
Iceland-21/4674.71%Helgason 2001
Ireland-3/1282.34%Helgason 2001
Italy (Tuscany)-2/484.20%Torroni 1996
La RiojaSpanish1/511.96%Martınez-Cruz 2012
North AragonSpanish0/260.00%Martınez-Cruz 2012
Orkney-5/1523.29%Helgason 2001
Saami-0/1760.00%Helgason 2001
Scandinavia-12/6451.86%Helgason 2001
Scotland-39/8914.38%Helgason 2001
Spain/Portugal-2/3520.57%Helgason 2001
Sweden-0/370.00%Torroni 1996
Western BizkaiaSpanish0/180.00%Martınez-Cruz 2012
Western Isles/Isle of Skye-15/2466.50%Helgason 2001

Eastern Europe

In Eastern Europe, the frequency of haplogroup I is generally lower than in Western Europe (1 to 3 percent), but its frequency is more consistent between populations with fewer places of extreme highs or lows. There are two notable exceptions. Nikitin 2009 found that Lemkos (a sub- or co-ethnic group of Rusyns) in the Carpathian mountains have the "highest frequency of haplogroup I (11.3%) in Europe, identical to that of the population of Krk Island (Croatia) in the Adriatic Sea".[Footnote 1][Footnote 2]

Population N Frequency Source
Boyko0/200.00%Nikitin 2009
Hutsul0/380.00%Nikitin 2009
Lemko6/5311.32%Nikitin 2009
Belorussians2/922.17%Belyaeva 2003
Russia (European)3/2151.40%Helgason 2001
Romanians (Constanta)590.00%Bosch 2006
Romanians (Ploiesti)462.17%Bosch 2006
Russia1/502.0%Malyarchuk 2001
Ukraine0/180.00%Malyarchuk 2001
Croatia (Mainland)4/2771.44%Pericic 2005
Croatia (Krk)15/13311.28%Cvjetan 2004
Croatia (Brac)1/1050.95%Cvjetan 2004
Croatia (Hvar)2/1081.9%Cvjetan 2004
Croatia (Korcula)1/981%Cvjetan 2004
Herzegovinians1/1300.8%Cvjetan 2004
Bosnians6/2472.4%Cvjetan 2004
Serbians4/1173.4%Cvjetan 2004
Macedonians2/1461.4%Cvjetan 2004
Macedonian Romani7/1534.6%Cvjetan 2004
Slovenians2/1041.92%Malyarchuk 2003
Bosnians4/1442.78%Malyarchuk 2003
Poles8/4361.83%Malyarchuk 2003
Caucasus (Georgia)*1/581.80%Quintana-Murci 2004
Russians5/2012.49%Malyarchuk 2003
Bulgaria/Turkey2/1021.96%Helgason 2001

Historic and Pre-Historic Samples

Haplogroup I has so far been absent from ancient European samples found in Paleolithic and Mesolithic grave sites. One early example has been found in Neolithic Spain (c. 5000 cal BC in Paternanbidea), but its subclade was not determined. Haplogroup I displays a strong connection with the Indo-European migrations; especially its I1, I1a1 and I3a subclades, which have been found in Poltavka and Srubnaya cultures in Russia (Mathieson 2015), among ancient Scythians (Der Sarkissian 2011), and in Corded Ware and Unetice Culture burials in Saxony (Brandt 2013). Haplogroup I (with undetermined subclades) has also been noted at significant frequencies in more recent historic grave sites (Melchior 2008 and Hofreiter 2010).

In 2013, Nature announced the publication of the first genetic study utilizing next-generation sequencing to ascertain the ancestral lineage of an Ancient Egyptian individual. The research was led by Carsten Pusch of the University of Tübingen in Germany and Rabab Khairat, who released their findings in the Journal of Applied Genetics. DNA was extracted from the heads of five Egyptian mummies that were housed at the institution. All the specimens were dated between 806 BC and 124 AD, a timeframe corresponding with the Late Dynastic and Ptolemaic periods. The researchers observed that one of the mummified individuals likely belonged to the I2 subclade.[2]

Samples with determined subclades

Culture Country Site Date Haplogroup Source
UneticeGermanyEsperstedt2050-1800 BCI1Adler 2012; Brandt 2013
SrubnayaRussiaRozhdestveno I, Samara Steppes, Samara1850-1600 BCI1a1Mathieson 2015
UneticeGermanyEulau1979-1921 BCI1a1Brandt 2013
UneticeGermanyPlotzkau 32200-1550 BCI1a1Brandt 2013
Ancient EgyptianEgypt806 BC-124 ADI2Khairat 2013
ScythianRussiaRostov-on-Don 500-200 BCI3Der Sarkissian 2011
UneticeGermanyBenzingerode-Heimburg1653-1627 BCI3aBrandt 2013
UneticeGermanyEsperstedt 2131-1979 BCI3aAdler 2012; Brandt 2013; Haak 2015; Mathieson 2015
UneticeGermanyEsperstedt 2199-2064 BCI3aAdler 2012; Brandt 2013; Haak 2015
PoltavkaRussiaLopatino II, Sok River, Samara2885-2665 BCI3aMathieson 2015
KarasukRussiaSabinka 21416-1268 BCI4a1Allentoft 2015
MinoanGreeceAyios Charalambos 2400-1700 BCI5Hughey 2013
MinoanGreeceAyios Charalambos 2400-1700 BCI5Hughey 2013
MinoanGreeceAyios Charalambos 2400-1700 BCI5Hughey 2013
Late Bronze AgeArmeniaNorabak 1209-1009 BCI5cAllentoft 2015
MezhovskavaRussiaKapova cave 1598-1398 BCI5cAllentoft 2015

Samples with unknown subclades

Populations N Frequency Source
Roman Iron Age sites
Bøgebjerggård (AD 1–400)
Simonsborg (AD 1–200)
Skovgaarde (AD 200–400)
3/24 12.5% Melchior 2008a, Hofreiter 2010
Viking Age burial sites
Galgedil (AD 1000)
Christian cemetery Kongemarken (AD 1000–1250)
medieval cemetery Riisby (AD 1250–1450)
4/29 13.79% Melchior 2008, Hofreiter 2010
Anglo-Saxon burial sites
Leicester:6
Lavington:6
Buckland:7
Norton:12
Norwich:17
1/48 2.08% Töpf 2006

We have previously observed a high frequency of Hg I's among Iron Age villagers (Bøgebjerggård) and individuals from the early Christian cemetery, Kongemarken [16], [17]. This trend was also found for the additional sites reported here, Simonsborg, Galgedil and Riisby. The overall frequency of Hg I among the individuals from the Iron Age to the Medieval Age is 13% (7/53) compared to 2.5% for modern Danes [35]. The higher frequencies of Hg I can not be ascribed to maternal kinship, since only two individuals share the same common motif (K2 and K7 at Kongemarken). Except for Skovgaarde (no Hg I's observed) frequencies range between 9% and 29% and there seems to be no trend in relation to time. No Hg I's were observed at the Neolithic Damsbo and the Bronze Age site Bredtoftegård, where all three individuals harboured Hg U4 or Hg U5a (Table 1).

Hofreiter 2010

The frequency of haplogroup I may have undergone a reduction in Europe following the Middle Ages. An overall frequency of 13% was found in ancient Danish samples from the Iron Age to the Medieval Age (including Vikings) from Denmark and Scandinavia compared to only 2.5% in modern samples. As haplogroup I is not observed in any ancient Italian, Spanish [contradicted by the above, "early examples have been found in Neolithic Spain (c. 5000 cal BC in Paternanbidea)"], British, central European populations, early central European farmers and Neolithic samples, according to the authors "Haplogroup I could therefore have been an ancient Southern Scandinavian type “diluted” by later immigration events" (Hofreiter 2010).

Subclades

Tree

This phylogenetic tree of haplogroup I subclades with time estimates is based on the paper (van Oven 2008) and subsequent published research (Behar 2012b).

Hg (April 2012) Time estimate (years) SD (years)
N1eI28'8816'095
I20'8573'594
I115'2313'402
I1a11'7263'306
I1a15'2942'134
I1a1a3'3272'720
I1a1b2'6082'973
I1a1c1'5233'384
I1a1d1'8921'863
I1b11'1354'818
I1c8'2163'787
I2-311'3084'154
I26'3872'449
I2a3'7712'143
I2a12'9861'968
I2b1'2674'539
I2c2'2682'693
I2d3'8283'795
I2e2'9363'454
I38'6793'410
I3a6'0913'262
I3a15'0703'017
I3b5'5963'629
I414'9135'955
I4a2'1246'113
I518'8064'005
I5a15'1164'128
I5a111'0624'661
I6--
I6a--

Distribution

I1

Haplogroup I1
Possible time of origin 15,231 ± 3,402 Before Present (Behar 2012b)
Possible place of origin Insufficient Data
Ancestor I
Defining mutations 455.1T, G6734A, G9966A, T16311C! (Behar & Family Tree DNA 2012)
Genbank IDPopulationSource
JQ702472Behar 2012b
JQ702567GermanyBehar 2012b
JQ704077GermanyBehar 2012b
JQ705190Behar 2012b
JQ705840Behar 2012b

I1a

Haplogroup I1a
Possible time of origin 11,726 ± 3,306 Before Present (Behar 2012b)
Possible place of origin Insufficient Data
Ancestor I1
Defining mutations T152C!, G207A (Behar & Family Tree DNA 2012)
Genbank IDPopulationSource
EU694173-FamilyTreeDNA
HM454265Turkey (Armenian)FamilyTreeDNA
JQ245746ChuvashFernandes 2012

I1a1

Haplogroup I1a1
Possible time of origin 5,294 ± 2,134 Before Present (Behar 2012b)
Possible place of origin Insufficient Data
Ancestor I1a
Defining mutations G203A, C3990T, G9947A, A9966G!, T10915C! (Behar & Family Tree DNA 2012)
Genbank IDPopulationSource
EF177414PortugalPereira 2007
JQ701900-Behar 2012b
JQ702519-Behar 2012b
JQ702820-Behar 2012b
JQ702882-Behar 2012b
JQ703835-Behar 2012b
JQ705025-Behar 2012b
JQ705645-Behar 2012b
FJ460562TunisiaCosta 2009
JQ705889-Behar 2012b
JQ245748CzechFernandes 2012
JQ245749CzechFernandes 2012
JQ245767TurkeyFernandes 2012
JQ245802MoroccoFernandes 2012

I1a1a

Haplogroup I1a1a
Possible time of origin 3,327 ± 2,720 Before Present (Behar 2012b)
Possible place of origin Insufficient Data
Ancestor I1a1
Defining mutations G9053A (Behar & Family Tree DNA 2012)
Genbank IDPopulationSource
AY339502FinlandFinnila 2001
AY339503FinlandFinnila 2001
AY339504FinlandFinnila 2001
AY339505FinlandFinnila 2001
AY339506FinlandFinnila 2001
AY339507FinlandFinnila 2001
AY339508FinlandFinnila 2001
AY339509FinlandFinnila 2001
JQ702939-Behar 2012b
JQ703652-Behar 2012b
JQ704013-Behar 2012b
JQ705140-Behar 2012b
JQ705378-Behar 2012b

I1a1b

Haplogroup I1a1b
Possible time of origin 2,608 ± 2,973 Before Present (Behar 2012b)
Possible place of origin Insufficient Data
Ancestor I1a1
Defining mutations T14182C (Behar & Family Tree DNA 2012)
Genbank IDPopulationSource
JQ702470-Behar 2012b
JQ705595-Behar 2012b
JQ704690-Behar 2012b

I1a1c

Haplogroup I1a1c
Possible time of origin About 1,523 Before Present (Behar 2012b)
Possible place of origin Insufficient Data
Ancestor I1a1
Defining mutations T6620C (Behar & Family Tree DNA 2012)
Genbank IDPopulationSource
JQ702023-Behar 2012b
JQ702457-Behar 2012b
GU123027RussiaMalyarchuk 2010b

I1a1d

Haplogroup I1a1d
Possible time of origin About 1,892 Before Present (Behar 2012b)
Possible place of origin Insufficient Data
Ancestor I1a1
Defining mutations A1836G, T4023C, T13488C, T16189C! (Behar & Family Tree DNA 2012)
Genbank IDPopulationSource
JQ702342-Behar 2012b
JQ705189-Behar 2012b

I1b

Haplogroup I1b
Possible time of origin 11,135 ± 4,818 Before Present (Behar 2012b)
Possible place of origin Insufficient Data
Ancestor I1
Defining mutations T6227C (Behar & Family Tree DNA 2012)
Genbank IDPopulationSource
AY195769CaucasianMishmar 2003
AY714041IndiaPalanichamy 2004
EF556153Jewish DiasporaBehar 2008a
FJ234984ArmenianFamilyTreeDNA
FJ968796-FamilyTreeDNA
JQ704018-Behar 2012b
JQ705376-Behar 2012b
KJ890387.1SwedishFamilyTreeDNA

I1c

Haplogroup I1c
Possible time of origin 8,216 ± 3,787 Before Present (Behar 2012b)
Possible place of origin Insufficient Data
Ancestor I1
Defining mutations G8573A, C16264T, G16319A, T16362C (Behar & Family Tree DNA 2012)
GenBank IDPopulationSource
EU564849-FamilyTreeDNA
JQ702655-Behar 2012b
JQ705364-Behar 2012b
JQ705932-Behar 2012b

I2'3

Haplogroup I2'3
Possible time of origin 11,308 ± 4,154 Before Present (Behar 2012b)
Possible place of origin Insufficient Data
Ancestor I
Defining mutations T152C!, G207A (Behar & Family Tree DNA 2012)

Examples of this ancestral branch have not been documented.

I2

Haplogroup I2
Possible time of origin 6,387 ± 2,449 Before Present (Behar 2012b)
Possible place of origin Insufficient Data
Ancestor I2'3
Defining mutations A15758G (Behar & Family Tree DNA 2012)
GenBank IDPopulationSource
FJ911909-FamilyTreeDNA
GU122984RussiaMalyarchuk 2010b
GU294854-FamilyTreeDNA
HQ287882-Pope 2011
JQ701942-Behar 2012b
JQ702191-Behar 2012b
JQ702284-Behar 2012b
JQ703850-Behar 2012b
JQ704705-Behar 2012b
JQ704765-Behar 2012b
JQ704936-Behar 2012b
JQ705000-Behar 2012b
JQ705304-Behar 2012b
JQ705379-Behar 2012b
EU570217-FamilyTreeDNA
JQ245744ChechnyaFernandes 2012
JQ245747CzechFernandes 2012
JQ245771TurkeyFernandes 2012

I2a

Haplogroup I2a
Possible time of origin 3,771 ± 2,143 Before Present (Behar 2012b)
Possible place of origin Insufficient Data
Ancestor I2
Defining mutations A11065G, G16145A (Behar & Family Tree DNA 2012)
GenBank IDPopulationSource
HQ326985-FamilyTreeDNA
HQ714959ScotlandFamilyTreeDNA
JQ703910-Behar 2012b
JQ705175-Behar 2012b
JQ705921-Behar 2012b
HQ695930-FamilyTreeDNA

I2a1

Haplogroup I2a1
Possible time of origin 2,986 ± 1,968 Before Present (Behar 2012b)
Possible place of origin Insufficient Data
Ancestor I2a
Defining mutations T3398C (Behar & Family Tree DNA 2012)

Current available data indicates that this may be a Northwestern European branch.

GenBank IDPopulationSource
AY339497FinlandFinnila 2001
HQ724528IrelandFamilyTreeDNA
JN411083IrelandFamilyTreeDNA

I2b

Haplogroup I2b
Possible time of origin About 1,267 Before Present (Behar 2012b)
Possible place of origin Insufficient Data
Ancestor I2
Defining mutations T6515C, 8281-8289d, A16166c (Behar & Family Tree DNA 2012)
GenBank IDPopulationSource
AY339498FinlandFinnila 2001
AY339499FinlandFinnila 2001
AY339500FinlandFinnila 2001
AY339501FinlandFinnila 2001

I2c

Haplogroup I2c
Possible time of origin About 2,268 Before Present (Behar 2012b)
Possible place of origin Insufficient Data
Ancestor I2
Defining mutations T460C, G9438A (Behar & Family Tree DNA 2012)
GenBank IDPopulationSource
JQ702163-Behar 2012b
JQ702253-Behar 2012b
JQ703024-Behar 2012b
JQ705187-Behar 2012b
JQ705666-Behar 2012b

I2d

Haplogroup I2d
Possible time of origin About 3,828 Before Present (Behar 2012b)
Possible place of origin Insufficient Data
Ancestor I2
Defining mutations G6480A (Behar & Family Tree DNA 2012)
GenBank IDPopulationSource
JQ705244-Behar 2012b
JQ703829-Behar 2012b

I2e

Haplogroup I2e
Possible time of origin About 2,936 Before Present (Behar 2012b)
Possible place of origin Insufficient Data
Ancestor I2
Defining mutations G3591A (Behar & Family Tree DNA 2012)
GenBank IDPopulationSource
JQ702578-Behar 2012b
JQ703106-Behar 2012b

I3

Haplogroup I3
Possible time of origin 8,679 ± 3,410 Before Present (Behar 2012b)
Possible place of origin Insufficient Data
Ancestor I2'3
Defining mutations T239C (Behar & Family Tree DNA 2012)
GenBank IDPopulationSource
JQ702493-Behar 2012b
JQ702647-Behar 2012b
JQ703862-Behar 2012b
JQ703883-Behar 2012b
JQ245751GreeceFernandes 2012

I3a

Haplogroup I3a
Possible time of origin 6,091 ± 3,262 Before Present (Behar 2012b)
Possible place of origin Oldest sample from Poltavka culture (Russia-Lopatino II, Sok River, Samara, 2885-2665 BC) (Mathieson 2015)
Ancestor I3
Defining mutations T16086C (Behar & Family Tree DNA 2012)
GenBank IDPopulationSource
EU746658FranceFamilyTreeDNA
EU869314-FamilyTreeDNA
JQ702062-Behar 2012b
JQ702109-Behar 2012b
JQ702413-Behar 2012b
JQ702041-Behar 2012b

I3a1

Haplogroup I3a1
Possible time of origin 5,070 ± 3,017 Before Present (Behar 2012b)
Possible place of origin Insufficient Data
Ancestor I3a
Defining mutations G2849A (Behar & Family Tree DNA 2012)
GenBank IDPopulationSource
AY963586ItalyBandelt 2005
HQ420832FranceFamilyTreeDNA
JQ704837-Behar 2012b

I3b

Haplogroup I3b
Possible time of origin 5,596 ± 3,629 Before Present (Behar 2012b)
Possible place of origin Insufficient Data
Ancestor I3
Defining mutations C16494T (Behar & Family Tree DNA 2012)
GenBank IDPopulationSource
GU590993IrelandFamilyTreeDNA
JQ705377-Behar 2012b

I4

Haplogroup I4
Possible time of origin 14,913 ± 5,955 Before Present (Behar 2012b)
Possible place of origin Insufficient Data
Ancestor I
Defining mutations G8519A (Behar & Family Tree DNA 2012)
GenBank IDPopulationSource
JQ704976-Behar 2012b
EF660987ItalyGasparre 2007

I4a

Haplogroup I4a
Possible time of origin About 2,124 Before Present (Behar 2012b)
Possible place of origin Insufficient Data
Ancestor I4
Defining mutations A10819G (Behar & Family Tree DNA 2012)
GenBank IDPopulationSource
EF153786SiberiaDerenko 2007
EU091245-FamilyTreeDNA
HM804481-FamilyTreeDNA
JN660158ArmenianFamilyTreeDNA
JQ701909-Behar 2012b
JQ701957-Behar 2012b
JQ705060-Behar 2012b
JQ705191-Behar 2012b
JQ705303-Behar 2012b
JQ705514-Behar 2012b
JQ705906-Behar 2012b
JQ706017-Behar 2012b
JQ702369-Behar 2012b

I5

Haplogroup I5
Possible time of origin 18,806 ± 4,005 Before Present (Behar 2012b)
Possible place of origin Insufficient Data
Ancestor I
Defining mutations A14233G (Behar & Family Tree DNA 2012)
GenBank IDPopulationSource
HQ658465German (north)FamilyTreeDNA
JQ245724North OssetiaFernandes 2012

I5a

Haplogroup I5a
Possible time of origin 15,116 ± 4,128 Before Present (Behar 2012b)
Possible place of origin Insufficient Data
Ancestor I5
Defining mutations T5074C, C16148T (Behar & Family Tree DNA 2012)
GenBank IDPopulationSource
FJ348190HutteritePichler 2008
JQ701894-Behar 2012b
JQ704768-Behar 2012b
JQ245733DubaiFernandes 2012
JQ245772TurkeyFernandes 2012
JQ245780YemenFernandes 2012
JQ245781YemenFernandes 2012
JQ245782YemenFernandes 2012
JQ245783YemenFernandes 2012
JQ245784YemenFernandes 2012
JQ245785YemenFernandes 2012
JQ245786YemenFernandes 2012

I5a1

Haplogroup I5a1
Possible time of origin 11,062 ± 4,661 Before Present (Behar 2012b)
Possible place of origin Insufficient Data
Ancestor I5a
Defining mutations 8281-8289d, A12961G (Behar & Family Tree DNA 2012)
GenBank IDPopulationSource
AF382007LeonMaca-Meyer 2001
EU597573Bedouin (Israel)Hartmann 2009
JQ704713-Behar 2012b
JQ705096-Behar 2012b
EF660917ItalyGasparre 2007
JQ245807BulgariaFernandes 2012

I6

Haplogroup I6
Possible time of origin Insufficient Data
Possible place of origin Insufficient Data
Ancestor I
Defining mutations T3645C (Behar & Family Tree DNA 2012)
GenBank IDPopulationSource
JQ245773TurkeyFernandes 2012

I6a

Haplogroup I6a
Possible time of origin Insufficient Data
Possible place of origin Insufficient Data
Ancestor I6
Defining mutations (G203A), G3915A, A6116G, A7804G, T15287C, (A16293c) (Behar & Family Tree DNA 2012)
GenBank IDPopulationSource
AY245555-Janssen 2006
JQ705382-Behar 2012b

See also

Genetics

Backbone mtDNA Tree

Evolutionary tree of human mitochondrial DNA (mtDNA) haplogroups

  Mitochondrial Eve (L)    
L0 L1–6
L1 L2 L3   L4 L5 L6
  M   N  
CZ D E G Q   O A S   R   I W X Y
C Z B F R0   pre-JT P  U
HV JT K
H V J T

References

Footnotes

  1. Nikitin 2009: 6/53 in Lemkos
    "Lemkos shared the highest frequency of haplogroup I ever reported and the highest frequency of haplogroup M* in the region."
  2. Cvjetan 2004: 15/133

Works Cited

Journals

Websites

Further reading

External links

  1. Non, Amy. "ANALYSES OF GENETIC DATA WITHIN AN INTERDISCIPLINARY FRAMEWORK TO INVESTIGATE RECENT HUMAN EVOLUTIONARY HISTORY AND COMPLEX DISEASE" (PDF). University of Florida. Retrieved 12 April 2016.
  2. Kefi R, Bouzaid E, Stevanovitch A, Beraud-Colomb E. "MITOCHONDRIAL DNA AND PHYLOGENETIC ANALYSIS OF PREHISTORIC NORTH AFRICAN POPULATIONS" (PDF). ISABS. Retrieved 5 March 2016.
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