Heparosan-N-sulfate-glucuronate 5-epimerase

Heparosan-N-sulfate-glucuronate 5-epimerase
Identifiers
EC number	5.1.3.17
CAS number	112567-86-9
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Search PMC articles PubMed articles NCBI proteins

Heparosan-N-sulfate-glucuronate 5-epimerase (EC 5.1.3.17, heparosan epimerase, heparosan-N-sulfate-D-glucuronosyl 5-epimerase, C-5 uronosyl epimerase, polyglucuronate epimerase, D-glucuronyl C-5 epimerase, poly[(1,4)-beta-D-glucuronosyl-(1,4)-N-sulfo-alpha-D-glucosaminyl] glucurono-5-epimerase) is an enzyme with systematic name poly((1->4)-beta-D-glucuronosyl-(1->4)-N-sulfo-alpha-D-glucosaminyl) glucurono-5-epimerase.^[1] This enzyme catalyses the following chemical reaction

heparosan-N-sulfate D-glucuronate $\rightleftharpoons$ heparosan-N-sulfate L-iduronate

This enzyme acts on D-glucuronosyl residues adjacent to sulfated D-glucosamine units in the heparin precursor.

See also

• heparan sulfate

References

1. Jacobsson, I., Bäckström, G., Höök, M., Lindahl, U., Feingold, D.S., Malmström, A. and Rodén, L. (1979). "Biosynthesis of heparin. Assay and properties of the microsomal uronosyl C-5 epimerase". J. Biol. Chem. 254: 2975–2982. PMID 107165.

External links

• Heparosan-N-sulfate-glucuronate 5-epimerase at the US National Library of Medicine Medical Subject Headings (MeSH)