Hepatitis C alternative reading frame stem-loop

Hepatitis C alternative reading frame stem-loop
Predicted secondary structure and sequence conservation of HCV_ARF_SL
Identifiers
Symbol HCV_ARF_SL
Rfam RF00620
Other data
RNA type Cis-reg
Domain(s) Viruses
SO 0000233

Hepatitis C alternative reading frame stem-loop is a conserved secondary structure motif identified in the RNA genome of the Hepatitis C virus (HCV) which is proposed to have an important role in regulating translation and repression of the viral genome.

The core protein-coding region of the Hepatitis C virus (HCV) genome contains a +1 alternative reading frame (ARF) and two proposed phylogenetically conserved RNA helix-forming stem loop structures (IV and VII).[1] The proteins translated from the ARF appear to be translated during the normal viral life cycle but are not essential to virus replication.[1] The two predicted stem loops shown here (SLV and SLVI) are proposed to be important for HCV translation and repression; these stem loops are located downstream of the Internal ribosome entry site (IRES) but their functional role is unknown.[1]

See also

References

  1. 1 2 3 McMullan LK, Grakoui A, Evans MJ, Mihalik K, Puig M, Branch AD,Feinstone SM, Rice CM; (2007). "Evidence for a functional RNA element in the hepatitis C virus coregene.". Proc Natl Acad Sci USA 104 (8): 2879–2884. doi:10.1073/pnas.0611267104. PMC 1815275. PMID 17299041.

External links

This article is issued from Wikipedia - version of the Sunday, April 06, 2014. The text is available under the Creative Commons Attribution/Share Alike but additional terms may apply for the media files.