Hexaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific)

Hexaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific)
Identifiers
EC number	2.5.1.83
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Search PMC articles PubMed articles NCBI proteins

Hexaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific) (EC 2.5.1.83, HexPS, hexaprenyl pyrophosphate synthetase, hexaprenyl diphosphate synthase) is an enzyme with systematic name (2E,6E)-farnesyl-diphosphate:isopentenyl-diphosphate farnesyltranstransferase (adding 3 isopentenyl units).^[1][2][3] This enzyme catalyses the following chemical reaction

(2E,6E)-farnesyl diphosphate + 3 isopentenyl diphosphate $\rightleftharpoons$ 3 diphosphate + all-trans-hexaprenyl diphosphate

The enzyme prefers farnesyl diphosphate to geranylgeranyl diphosphate as an allylic substrate.

References

1. Fujii, H., Koyama, T. and Ogura, K. (1982). "Hexaprenyl pyrophosphate synthetase from Micrococcus luteus B-P 26. Separation of two essential components". J. Biol. Chem. 257 (24): 14610–14612. PMID 7174655.
2. Shimizu, N., Koyama, T. and Ogura, K. (1998). "Molecular cloning, expression, and characterization of the genes encoding the two essential protein components of Micrococcus luteus B-P 26 hexaprenyl diphosphate synthase". J. Bacteriol. 180 (6): 1578–1581. PMC 107062. PMID 9515931.
3. Nagaki, M., Kimura, K., Kimura, H., Maki, Y., Goto, E., Nishino, T. and Koyama, T. (2001). "Artificial substrates of medium-chain elongating enzymes, hexaprenyl- and heptaprenyl diphosphate synthases". Bioorg. Med. Chem. Lett. 11 (16): 2157–2159. doi:10.1016/S0960-894X(01)00391-2. PMID 11514159.

External links

• Hexaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific) at the US National Library of Medicine Medical Subject Headings (MeSH)