Hexaprenyl diphosphate synthase (geranylgeranyl-diphosphate specific)

Hexaprenyl diphosphate synthase (geranylgeranyl-diphosphate specific) (EC 2.5.1.82, HexPS, (all-E) hexaprenyl diphosphate synthase, (all-trans) hexaprenyl diphosphate synthase, hexaprenyl pyrophosphate synthase, HexPPs, hexaprenyl diphosphate synthase) is an enzyme with systematic name geranylgeranyl-diphosphate:isopentenyl-diphosphate transferase (adding 2 isopentenyl units).^[1]^[2]^[3] This enzyme catalyses the following chemical reaction

geranylgeranyl diphosphate + 2 isopentenyl diphosphate

\rightleftharpoons

2 diphosphate + all-trans-hexaprenyl diphosphate

The enzyme prefers geranylgeranyl diphosphate to farnesyl diphosphate as an allylic substrate.

References

↑ Hemmi, H., Ikejiri, S., Yamashita, S. and Nishino, T. (2002). "Novel medium-chain prenyl diphosphate synthase from the thermoacidophilic archaeon Sulfolobus solfataricus". J. Bacteriol. 184 (3): 615–620. doi:10.1128/JB.184.3.615-620.2002. PMC 139513. PMID 11790729.
↑ Hemmi, H., Noike, M., Nakayama, T. and Nishino, T. (2002). "Change of product specificity of hexaprenyl diphosphate synthase from Sulfolobus solfataricus by introducing mimetic mutations". Biochem. Biophys. Res. Commun. 297 (5): 1096–1101. doi:10.1016/S0006-291X(02)02348-3. PMID 12372398.
↑ Sun, H.Y., Ko, T.P., Kuo, C.J., Guo, R.T., Chou, C.C., Liang, P.H. and Wang, A.H. (2005). "Homodimeric hexaprenyl pyrophosphate synthase from the thermoacidophilic crenarchaeon Sulfolobus solfataricus displays asymmetric subunit structures". J. Bacteriol. 187 (23): 8137–8148. doi:10.1128/JB.187.23.8137-8148.2005. PMC 1291270. PMID 16291686.

External links

Hexaprenyl diphosphate synthase (geranylgeranyl-diphosphate specific) at the US National Library of Medicine Medical Subject Headings (MeSH)

Transferases: alkyl and aryl (EC 2.5)

2.5.1	Dimethylallyltranstransferase Thiaminase I Methionine adenosyltransferase Riboflavin synthase Dihydropteroate synthase Spermidine synthase Glutathione S-transferase Farnesyl-diphosphate farnesyltransferase Spermine synthase Alkylglycerone phosphate synthase Farnesyltransferase Geranylgeranyltransferase type 1 Porphobilinogen deaminase

Enzymes

Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Catalytically perfect enzyme Coenzyme Cofactor Enzyme catalysis Enzyme kinetics Lineweaver–Burk plot Michaelis–Menten kinetics

Regulation	Allosteric regulation Cooperativity Enzyme inhibitor

Classification	EC number Enzyme superfamily Enzyme family List of enzymes

Types	EC1 Oxidoreductases(list) EC2 Transferases(list) EC3 Hydrolases(list) EC4 Lyases(list) EC5 Isomerases(list) EC6 Ligases(list)

This article is issued from Wikipedia - version of the Thursday, March 31, 2016. The text is available under the Creative Commons Attribution/Share Alike but additional terms may apply for the media files.