Hol44 family

The Holin Hol44 (Hol44) Family (TC# 1.E.29) is a group of transporters belonging to the Holin Superfamily V.^[1] A representative list of proteins belonging to the Hol44 family from caudovirales and firmicutes can be found in the Transporter Classification Database.

One characteristic member of the Hol44 family is oenophage fOg44 (Lys44; TC# 1.E.29.2.1), which secretes an endolysin that Oenococcus oeni cells are intrinsically resistant to. Experiments with several antimicrobials support the hypothesis that the full activity of Lys44 requires sudden ion-nonspecific dissipation of the proton motive force, an event undertaken by the fOg44 holin in the phage infection context.^[2]

See also

• Holin
• Lysin
• Transporter Classification Database

Further reading

• "hol44 - Hol44 - Oenococcus phage fOg44 - hol44 gene & protein". www.uniprot.org. Retrieved2016-03-21.
• Goh, Shan; Ong, Peh Fern; Song, Keang Peng; Riley, Thomas V.; Chang, Barbara J. (2007-03-01)."The complete genome sequence of Clostridium difficile phage phiC2 and comparisons to phiCD119 and inducible prophages of CD630". Microbiology (Reading, England)153 (Pt 3): 676–685. doi:10.1099/mic.0.2006/002436-0.ISSN 1350-0872. PMID 17322187.
• Oki, M.; Kakikawa, M.; Nakamura, S.; Yamamura, E. T.; Watanabe, K.; Sasamoto, M.; Taketo, A.; Kodaira, K. (1997-09-15). "Functional and structural features of the holin HOL protein of the Lactobacillus plantarum phage phi gle: analysis in Escherichia coli system". Gene 197 (1-2): 137–145. ISSN 0378-1119.PMID 9332359.

References

1. Reddy, Bhaskara L.; Saier Jr., Milton H. (2013-11-01). "Topological and phylogenetic analyses of bacterial holin families and superfamilies". Biochimica et Biophysica Acta (BBA) - Biomembranes 1828 (11): 2654–2671. doi:10.1016/j.bbamem.2013.07.004. PMC 3788059. PMID 23856191.
2. Nascimento, João Gil; Guerreiro-Pereira, Maria Carolina; Costa, Sérgio Fernandes; São-José, Carlos; Santos, Mário Almeida (2008-01-01). "Nisin-triggered activity of Lys44, the secreted endolysin from Oenococcus oeni phage fOg44". Journal of Bacteriology 190 (1): 457–461. doi:10.1128/JB.01195-07. ISSN 1098-5530. PMC 2223723. PMID 17981964.

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