Holin superfamily V

The Holin superfamily V is a group of integral membrane transport proteins. There are seven different holin superfamilies in total. In general, these proteins are believed to play a role in regulated cell death, although functionality varies between families and individual members. The Holin superfamily V includes the TC families:^[1]

• 1.E.21 - The Listeria Phage A118 Holin (Hol118) Family
• 1.E.29 - The Holin Hol44 (Hol44) Family

Superfamily V includes protein families classified in the Transporter Classification Database as TC# 1.E.21 and TC# 1.E.29. Both families possess members from Firmicutes, Actinobacteria and Chloroflexi. Proteins of this superfamily all appear to have 3 transmembrane segments (TMSs) and have average sizes of 97 and 101 amino acyl residues (aas), respectively.^[2]

See also

• Holin
• Lysin
• Transporter Classification Database

References

1. "Holin Superfamily V". Transporter Classification Database. Retrieved 2016-03-20.
2. Reddy, Bhaskara L.; Saier Jr., Milton H. (2013-11-01). "Topological and phylogenetic analyses of bacterial holin families and superfamilies". Biochimica et Biophysica Acta (BBA) - Biomembranes 1828 (11): 2654–2671. doi:10.1016/j.bbamem.2013.07.004. PMC 3788059. PMID 23856191.