Homospermidine synthase

Homospermidine synthase
Identifiers
EC number	2.5.1.44
CAS number	76106-84-8
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Search PMC articles PubMed articles NCBI proteins

Homospermidine synthase (EC 2.5.1.44) is an enzyme with systematic name putrescine:putrescine 4-aminobutyltransferase (ammonia-forming).^{[1][2][3][4][5][6]} This enzyme catalyses the following chemical reaction

(1) 2 putrescine $\rightleftharpoons$ sym-homospermidine + NH₃ + H⁺

(2) putrescine + spermidine $\rightleftharpoons$ sym-homospermidine + propane-1,3-diamine

The reaction of this enzyme occurs in three steps.

References

1. Tait, G.H. (1979). "The formation of homospermidine by an enzyme from Rhodopseudomonas viridis". Biochem. Soc. Trans. 7 (1): 199–200. PMID 437275.
2. Böttcher, F., Ober, D. and Hartmann, T. (1994). "Biosynthesis of pyrrolizidine alkaloids: putrescine and spermidine are essential substrates of enzymatic homospermidine formation". Can. J. Chem. 72: 80–85. doi:10.1139/v94-013.
3. Yamamoto, S., Nagata, S. and Kusaba, K. (1993). "Purification and characterization of homospermidine synthase in Acinetobacter tartarogens ATCC 31105". J. Biochem. 114 (1): 45–49. PMID 8407874.
4. Srivenugopal, K.S. and Adiga, P.R. (1980). "Enzymatic synthesis of sym-homospermidine in Lathyrus sativus T (grass pea) seedlings". Biochem. J. 190 (2): 461–464. PMC 1162113. PMID 7470060.
5. Ober, D., Tholl, D., Martin, W. and Hartmann, T. (1996). "Homospermidine synthase of Rhodopseudomonas viridis: Substrate specificity and effects of the heterologously expressed enzyme on polyamine metabolism of Escherichia coli". J. Gen. Appl. Microbiol. 42 (5): 411–419. doi:10.2323/jgam.42.411.
6. Ober, D. and Hartmann, T. (1999). "Homospermidine synthase, the first pathway-specific enzyme of pyrrolizidine alkaloid biosynthesis, evolved from deoxyhypusine synthase". Proc. Natl. Acad. Sci. USA 96 (26): 14777–14782. Bibcode:1999PNAS...9614777O. doi:10.1073/pnas.96.26.14777. PMC 24724. PMID 10611289.

External links

• Homospermidine synthase at the US National Library of Medicine Medical Subject Headings (MeSH)