Human T-lymphotropic virus

Human T-lymphotropic virus
Virus classification
Group: Group VI (ssRNA-RT)
Family: Retroviridae
Subfamily: Orthoretrovirinae
Genus: Deltaretrovirus
Species: Simian T-lymphotropic virus
Serotypes

Human T-lymphotropic virus

The human T-lymphotropic virus or human T-cell lymphotropic virus (HTLV) family of viruses are a group of human retroviruses that are known to cause a type of cancer called adult T-cell leukemia/lymphoma and a demyelinating disease called HTLV-I associated myelopathy/tropical spastic paraparesis (HAM/TSP). The HTLVs belong to a larger group of primate T-lymphotropic viruses (PTLVs). Members of this family that infect humans are called HTLVs, and the ones that infect Old World monkeys are called Simian T-lymphotropic viruses (STLVs). To date, four types of HTLVs (human T-lymphotropic virus 1 [HTLV-I], human T-lymphotropic virus 2 [HTLV-II], HTLV-III, and HTLV-IV) and four types of STLVs (STLV-I, STLV-II, STLV-III, and STLV-V) have been identified. The HTLVs are believed to originate from intraspecies transmission of STLVs. The original name for HIV, the virus that causes AIDS, was HTLV-III; this term is no longer in use . The HTLV-1 genome is diploid, composed of two copies of a single-stranded RNA virus whose genome is copied into a double-stranded DNA form that integrates into the host cell genome, at which point the virus is referred to as a provirus. A closely related virus is bovine leukemia virus BLV.

HTLV-I

HTLV-I is an abbreviation for human T-cell lymphotropic virus type 1, also called human T-cell leukemia type 1, a virus that has been seriously implicated in several kinds of diseases, including HTLV-I-associated myelopathy, and as a virus cancer link for leukemia (see adult T-cell leukemia/lymphoma). HTLV was discovered by Luc Antoine Montagnier (born 18 August 1932) a French virologist along with Françoise Barré-Sinoussi and Harald zur Hausen. Robert Gallo and colleagues were also involved in 1980.[1] Between 1 in 20 and 1 in 25 infected persons are thought to develop cancer as a result of the virus.[2]

HTLV-II

A virus closely related to HTLV-I, also discovered by Robert Gallo and colleagues,[3] HTLV-II shares approximately 70% genomic homology (structural similarity) with HTLV-I.

HTLV-III is currently the name used to describe another virus related to HTLV-I and HTLV-II. "HTLV-IV" has been used to describe recently characterized viruses.[4][5][6]

These viruses were discovered in 2005 in rural Cameroon, and were, it is presumed, transmitted from monkeys to hunters of monkeys through bites and scratches.

It is not yet known how much further transmission has occurred among humans, or whether the viruses can cause disease.

The use of these names can cause some confusion, because the name HTLV-III was one of the names for HIV in early AIDS literature, but has since fallen out of use.[10] The name HTLV-IV has also been used to describe HIV-2.[11] A large Canadian study documented this confusion among healthcare workers, where >90% of HTLV tests ordered by physicians were actually intended to be HIV tests.[12]

Transmission

HTLV-I and HTLV-II can be transmitted sexually,[13][14] by blood to blood contact (e.g. by blood transfusion or sharing needles when using drugs)[15][16] and via breast feeding.[17]

Research

While there is no present licensed vaccine, there are many factors which make a vaccine against HTLV-1 feasible. The virus displays relatively low antibody production variability, natural immunity does occur in humans, and experimental vaccination using envelope antigens has been shown to be successful in animal models. Four HTLVs are well established. HTLV-1 and HTLV-2 are both involved in actively spreading epidemics, affecting 15-20 million people worldwide. HTLV-1 is the more clinically significant of the two, as it has been proven to be the etiologic agent of multiple disorders. At least 500,000 of the individuals infected with HTLV-1 eventually develop an often rapidly fatal leukemia, while others will develop a debilitative myelopathy, and yet others will experience uveitis, infectious dermatitis, or another inflammatory disorder. HTLV-2 is associated with milder neurologic disorders and chronic pulmonary infections. The novel HTLV-3 and HTLV-4 have been isolated only in a few cases; no specific illnesses have yet been associated with these viruses. Plasmid DNA vaccines elicit potent and protective immune responses in numerous small-animal models of infectious diseases. However, their immunogenicity in primates appears less potent. In the United States, HTLV-I/II seroprevalence rates among volunteer blood donors average 0.016 percent. Approximately half of HTLV-I/II-seropositive blood donors nationwide are infected with HTLV-I. HTLV-I infected donors most often report a history of birth in HTLV-I endemic countries or sexual contact with persons from the Caribbean or Japan. In the past two decades a large initiative has been put forth to understand the biological and pathogenic properties of the human T-cell lymphotropic virus type 1 (HTLV-1); this has ultimately led to the development of various experimental vaccination and therapeutic strategies to combat HTLV-1 infection. These strategies include the development of envelope glycoprotein derived B-cell epitopes for the induction of neutralizing antibodies, as well as a strategy to generate a multivalent cytotoxic T-lymphocyte (CTL) response against the HTLV-1 Tax antigen. A vaccine candidate that can elicit or boost anti-gp46 neutralizing antibody response may have a potential for prevention and therapy against HTLV-1 infection.[18] Potential treatments include prosultiamine, a vitamin B-1 derivative, which has been shown to reduce viral load and symptoms;[19] azacytidine, an anti-metabolite, which has been credited with the cure of a patient in Greece;[20] tenofovir disoproxil (TDF), a reverse-transcriptase inhibitor used for HIV; cepharanthine, an alkaloid from stephania cepharantha hayata;[21] and phosphonated carbocyclic 2'-oxa-3'aza nucleosides (PCOANs).[22] A newer formulation of TDF, called tenofovir alafenamide (TAF), also has promise as a treatment with less toxicity.

References

  1. ↑ Detection and isolation of type C retrovirus particles from fresh and cultured lymphocytes of a patient with cutaneous T-cell lymphoma. Poiesz BJ, Ruscetti FW, Gazdar AF, Bunn PA, Minna JD, Gallo RC. Proc Natl Acad Sci U S A. 1980 Dec; 77(12):7415–9
  2. ↑ WELSH, JAMES S. (January 2011). "Contagious Cancer". The Oncologist 16 (1): 1–4. doi:10.1634/theoncologist.2010-0301. PMC 3228048. PMID 21212437.
  3. ↑ Kalyanaraman, V.S., Sarngadharan, M.G., Robert Guroff, M., Miyoshi, I., Blayney, D., Golde, D., and Gallo, R.C.: A new subtype of human T cell leukemia virus (HTLV II) associated with a T cell variant of hairy cell leukemia. Science 218: 571–573, 1982.
  4. ↑ Mahieux, R; Gessain, A (2005). "Les nouveaux rétrovirus humains HTLV-3 et HTLV-4" [New human retroviruses: HTLV-3 and HTLV-4] (PDF). Médecine tropicale (in French) 65 (6): 525–8. PMID 16555510.
  5. ↑ Calattini, S.; Chevalier, S. A.; Duprez, R.; Afonso, P.; Froment, A.; Gessain, A.; Mahieux, R. (2006). "Human T-Cell Lymphotropic Virus Type 3: Complete Nucleotide Sequence and Characterization of the Human Tax3 Protein". Journal of Virology 80 (19): 9876–88. doi:10.1128/JVI.00799-06. PMC 1617244. PMID 16973592.
  6. ↑ Mahieux, R.; Gessain, Antoine (2009). "The human HTLV-3 and HTLV-4 retroviruses: New members of the HTLV family". Pathologie Biologie 57 (2): 161–6. doi:10.1016/j.patbio.2008.02.015. PMID 18456423.
  7. ↑ Calattini, Sara; Betsem, Edouard; Bassot, Sylviane; Chevalier, SéBastien Alain; Mahieux, Renaud; Froment, Alain; Gessain, Antoine (2009). "New Strain of Human T Lymphotropic Virus (HTLV) Type 3 in a Pygmy from Cameroon with Peculiar HTLV Serologic Results". The Journal of Infectious Diseases 199 (4): 561–4. doi:10.1086/596206. PMID 19099485.
  8. ↑ Chevalier, S. A.; Ko, N. L.; Calattini, S.; Mallet, A.; Prevost, M.-C.; Kehn, K.; Brady, J. N.; Kashanchi, F.; et al. (2008). "Construction and Characterization of a Human T-Cell Lymphotropic Virus Type 3 Infectious Molecular Clone". Journal of Virology 82 (13): 6747–52. doi:10.1128/JVI.00247-08. PMC 2447071. PMID 18417569.
  9. ↑ Human T-Lymphotropic Virus Type III at the US National Library of Medicine Medical Subject Headings (MeSH)
  10. ↑ Human T Lymphotropic Virus Type IV at the US National Library of Medicine Medical Subject Headings (MeSH)
  11. ↑ Siemieniuk, Reed; Fonseca, Kevin; Gill M. John (November 2012). "Using Root Cause Analysis and Form Redesign to Reduce Incorrect Ordering of HIV Tests". The Joint Commission Journal on Quality and Patient Safety. 11 38 (11): 506–512. PMID 23173397.
  12. ↑ Rodriguez, Evelyn M.; de Moya, E. Antonio; Guerrero, Ernesto; Monterroso, Edgar R.; Quinn, Thomas C.; Puello, Elizardo; de Quiñones, Margarita Rosado; Thorington, Bruce; et al. (1993). "HIV-1 and HTLV-I in sexually transmitted disease clinics in the Dominican Republic". Journal of acquired immune deficiency syndromes 6 (3): 313–8. PMID 8450407.
  13. ↑ Roucoux, Diana F.; Wang, Baoguang; Smith, Donna; Nass, Catharie C.; Smith, James; Hutching, Sheila T.; Newman, Bruce; Lee, Tzong-Hae; et al. (2005). "A Prospective Study of Sexual Transmission of Human T Lymphotropic Virus (HTLV)-I and HTLV-II". The Journal of Infectious Diseases 191 (9): 1490–7. doi:10.1086/429410. PMID 15809908.
  14. ↑ http://www.htlv1.eu/htlv_one.html#how
  15. ↑ http://www.htlv1.eu/htlv_two.html#how
  16. ↑ Coovadia HM et al. Mother-to-child transmission of HIV-1 infection during exclusive breastfeeding in the first 6 months of life :An intervention cohort study" Lancet 2007, 369(9567) 1107-1116.
  17. ↑ Neutralizing antibodies against human T cell leukemia virus type-I (HTLV-1) eradicate HTLV-1 in combination with autologous peripheral blood mononuclear cells via antibody-dependent cellular cytotoxicity while preventing new infection
  18. ↑ Nervous System Disease: A New Outlet for an Old Drug?
  19. ↑ Antiretroviral activity of 5-azacytidine during treatment of a HTLV-1 positive myelodysplastic syndrome with autoimmune manifestations
  20. ↑ Synergistic inhibition of HTLV-1-infected cell proliferation by combination of cepharanthine and a tetramethylnaphthalene derivative
  21. ↑ MacChi, B.; Balestrieri, E.; Ascolani, A.; Hilburn, S.; Martin, F.; Mastino, A.; Taylor, G. P. (2011). "Susceptibility of Primary HTLV-1 Isolates from Patients with HTLV-1-Associated Myelopathy to Reverse Transcriptase Inhibitors". Viruses 3 (12): 469–483. doi:10.3390/v3050469. PMC 3185762. PMID 21994743.

External links

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