Cepharanthine
Cepharanthine
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Clinical data |
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AHFS/Drugs.com |
International Drug Names |
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Identifiers |
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ATC code |
none |
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PubChem |
CID 10206 |
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ChemSpider |
9791 |
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ChEMBL |
CHEMBL449782 |
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Synonyms |
Cepharantin, O-Methylcepharanoline |
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Chemical data |
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Formula |
C37H38N2O6 |
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Molar mass |
606.70742 g/mol |
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CN1CCC2=CC3=C(C4=C2[C@@H]1CC5=CC=C(C=C5)OC6=C(C=CC(=C6)C[C@@H]7C8=CC(=C(C=C8CCN7C)OC)O4)OC)OCO3
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InChI=1S/C37H38N2O6/c1-38-13-11-24-18-31(41-4)33-20-27(24)28(38)16-23-7-10-30(40-3)32(17-23)44-26-8-5-22(6-9-26)15-29-35-25(12-14-39(29)2)19-34-36(37(35)45-33)43-21-42-34/h5-10,17-20,28-29H,11-16,21H2,1-4H3/t28-,29+/m1/s1 Key:YVPXVXANRNDGTA-WDYNHAJCSA-N
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Cepharanthine is an antiinflammatory and antineoplastic compound isolated from Stephania.[1] Due to these modalities, it has been shown effective against HTLV in lab research. [2] Additionally, it has successfully been used to treat a diverse range of medical conditions, including radiation-induced leukopenia, idiopathic thrombocytopenic purpura, alopecia areata, alopecia pityrodes, venomous snakebites, xerostomia, sarcoidosis, refractory anemia and various cancer-related conditions. No safety issues have been observed with CEP, and side effects are very rarely reported. [3]
References
- ↑ Huang, H.; Hu, G.; Wang, C.; Xu, H.; Chen, X.; Qian, A. (2013). "Cepharanthine, an Alkaloid from Stephania cepharantha Hayata, Inhibits the Inflammatory Response in the RAW264.7 Cell and Mouse Models". Inflammation 37 (1): 235–46. doi:10.1007/s10753-013-9734-8. PMID 24045962.
- ↑ Synergistic inhibition of HTLV-1-infected cell proliferation by combination of cepharanthine and a tetramethylnaphthalene derivative.
- ↑ Therapeutic potential of the biscoclaurine alkaloid, cepharanthine, for a range of clinical conditions.