Cepharanthine

Cepharanthine
Clinical data
AHFS/Drugs.com International Drug Names
Identifiers
ATC code none
PubChem CID 10206
ChemSpider 9791
ChEMBL CHEMBL449782
Synonyms Cepharantin, O-Methylcepharanoline
Chemical data
Formula C37H38N2O6
Molar mass 606.70742 g/mol

Cepharanthine is an antiinflammatory and antineoplastic compound isolated from Stephania.[1] Due to these modalities, it has been shown effective against HTLV in lab research. [2] Additionally, it has successfully been used to treat a diverse range of medical conditions, including radiation-induced leukopenia, idiopathic thrombocytopenic purpura, alopecia areata, alopecia pityrodes, venomous snakebites, xerostomia, sarcoidosis, refractory anemia and various cancer-related conditions. No safety issues have been observed with CEP, and side effects are very rarely reported. [3]

References

  1. Huang, H.; Hu, G.; Wang, C.; Xu, H.; Chen, X.; Qian, A. (2013). "Cepharanthine, an Alkaloid from Stephania cepharantha Hayata, Inhibits the Inflammatory Response in the RAW264.7 Cell and Mouse Models". Inflammation 37 (1): 235–46. doi:10.1007/s10753-013-9734-8. PMID 24045962.
  2. Synergistic inhibition of HTLV-1-infected cell proliferation by combination of cepharanthine and a tetramethylnaphthalene derivative.
  3. Therapeutic potential of the biscoclaurine alkaloid, cepharanthine, for a range of clinical conditions.


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