Hydroxylamine dehydrogenase

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Hydroxylamine dehydrogenase (EC 1.7.2.6, HAO (ambiguous)) is an enzyme with systematic name hydroxylamine:ferricytochrome-c oxidoreductase.^[1]^[2]^[3]^[4]^[5] This enzyme catalyses the following chemical reaction

(1) hydroxylamine + H₂O + 2 ferricytochrome c

\rightleftharpoons

nitrite + 2 ferrocytochrome c + 5 H⁺

(2) hydroxylamine + ferricytochrome c

\rightleftharpoons

nitric oxide + ferrocytochrome c + 3 H⁺

The enzymes from the nitrifying bacterium Nitrosomonas europaea and the methylotrophic bacterium Methylococcus capsulatus are hemoproteins.

References

↑ Rees, M. (1968). "Studies of the hydroxylamine metabolism of Nitrosomonas europaea. I. Purification of hydroxylamine oxidase". Biochemistry 7: 353–366. doi:10.1021/bi00841a045. PMID 5758552.
↑ Hooper, A.B. and Terry, K.R. (1979). "Hydroxylamine oxidoreductase of Nitrosomonas. Production of nitric oxide from hydroxylamine". Biochim. Biophys. Acta 571 (1): 12–20. doi:10.1016/0005-2744(79)90220-1. PMID 497235.
↑ Hooper, A.B. and Balny, C. (1982). "Reaction of oxygen with hydroxylamine oxidoreductase of Nitrosomonas: fast kinetics". FEBS Lett. 144: 299–303. doi:10.1016/0014-5793(82)80658-3. PMID 7117545.
↑ Lipscomb, J.D. and Hooper, A.B. (1982). "Resolution of multiple heme centers of hydroxylamine oxidoreductase from Nitrosomonas. 1. Electron paramagnetic resonance spectroscopy". Biochemistry 21: 3965–3972. doi:10.1021/bi00260a010. PMID 6289867.
↑ Poret-Peterson, A.T., Graham, J.E., Gulledge, J. and Klotz, M.G. (2008). "Transcription of nitrification genes by the methane-oxidizing bacterium, Methylococcus capsulatus strain Bath". ISME J. 2 (12): 1213–1220. doi:10.1038/ismej.2008.71. PMID 18650926.

External links

Hydroxylamine dehydrogenase at the US National Library of Medicine Medical Subject Headings (MeSH)

Oxidoreductases: nitrogenous donor (EC 1.7)

1.7.1	GMP reductase

1.7.2	Nitrite reductase (NO-forming)

1.7.3	Urate oxidase

1.7.7	Ferredoxin—nitrite reductase

1.7.99	Hydroxylamine reductase

Enzymes

Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Catalytically perfect enzyme Coenzyme Cofactor Enzyme catalysis Enzyme kinetics Lineweaver–Burk plot Michaelis–Menten kinetics

Regulation	Allosteric regulation Cooperativity Enzyme inhibitor

Classification	EC number Enzyme superfamily Enzyme family List of enzymes

Types	EC1 Oxidoreductases(list) EC2 Transferases(list) EC3 Hydrolases(list) EC4 Lyases(list) EC5 Isomerases(list) EC6 Ligases(list)

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