Hydroxylamine oxidase

hydroxylamine oxidase
Identifiers
EC number	1.7.3.4
CAS number	9075-43-8
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / EGO
Search PMC articles PubMed articles NCBI proteins

In enzymology, a hydroxylamine oxidase (EC 1.7.3.4) is an enzyme that catalyzes the chemical reaction

hydroxylamine + O₂ $\rightleftharpoons$ nitrite + H₂O

Thus, the two substrates of this enzyme are hydroxylamine and O₂, whereas its two products are nitrite and H₂O.

This enzyme belongs to the family of oxidoreductases, specifically those acting on other nitrogenous compounds as donors with oxygen as acceptor. The systematic name of this enzyme class is hydroxylamine:oxygen oxidoreductase. Other names in common use include HAO and hydroxylamine oxidoreductase. This enzyme participates in nitrogen metabolism. It employs one cofactor, heme.

Structural studies

As of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code 1FGJ.

References

• Hooper AB, Balny C (1982). "Reaction of oxygen with hydroxylamine oxidoreductase of Nitrosomonas: fast kinetics". FEBS Lett. 144 (2): 299–303. doi:10.1016/0014-5793(82)80658-3. PMID 7117545.
• Lipscomb JD, Hooper AB (1982). "Resolution of multiple heme centers of hydroxylamine oxidoreductase from Nitrosomonas. 1. Electron paramagnetic resonance spectroscopy". Biochemistry. 21 (17): 3965–72. doi:10.1021/bi00260a010. PMID 6289867.
• Rees MK (1968). "Studies of the hydroxylamine metabolism of Nitrosomonas europaea. I Purification of hydroxylamine oxidase". Biochemistry. 7 (1): 353–66. doi:10.1021/bi00841a045. PMID 5758552.