IGBP1

Immunoglobulin (CD79A) binding protein 1
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 4IYP​
Identifiers
Symbols	IGBP1 ; ALPHA-4; IBP1
External IDs	OMIM: 300139 MGI: 1346500 HomoloGene: 44067 GeneCards: IGBP1 Gene
Gene ontology Molecular function • protein binding • protein phosphatase type 2A regulator activity • protein domain specific binding • mitogen-activated protein kinase kinase binding • protein complex binding • protein phosphatase 2A binding Cellular component • cytoplasm • cytosol • microtubule Biological process • negative regulation of transcription from RNA polymerase II promoter • signal transduction • negative regulation of stress-activated MAPK cascade • regulation of protein phosphatase type 2A activity • response to tumor necrosis factor • positive regulation of dephosphorylation • negative regulation of protein dephosphorylation • B cell activation • negative regulation of cysteine-type endopeptidase activity involved in apoptotic process • positive regulation of transcription from RNA polymerase II promoter • regulation of microtubule-based movement • response to interleukin-1 • negative regulation of apoptotic signaling pathway Sources: Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	3476	18518
Ensembl	ENSG00000089289	ENSMUSG00000031221
UniProt	P78318	Q61249
RefSeq (mRNA)	NM_001551	NM_008784
RefSeq (protein)	NP_001542	NP_032810
Location (UCSC)	Chr X: 70.13 – 70.17 Mb	Chr X: 100.49 – 100.52 Mb
PubMed search

Immunoglobulin-binding protein 1 is a protein that in humans is encoded by the IGBP1 gene.^[1][2]

Function

The proliferation and differentiation of B cells is dependent upon a B-cell antigen receptor (BCR) complex. Binding of antigens to specific B-cell receptors results in a tyrosine phosphorylation reaction through the BCR complex and leads to multiple signal transduction pathways.^[2]

Interactions

IGBP1 has been shown to interact with PPP4C,^[3][4][5] PPP6C^[4][5] and PPP2CA.^[4][5][6][7]

References

1. Onda M, Inui S, Maeda K, Suzuki M, Takahashi E, Sakaguchi N (Dec 1997). "Expression and chromosomal localization of the human alpha 4/IGBP1 gene, the structure of which is closely related to the yeast TAP42 protein of the rapamycin-sensitive signal transduction pathway". Genomics 46 (3): 373–8. doi:10.1006/geno.1997.5048. PMID 9441740.
2. "Entrez Gene: IGBP1 immunoglobulin (CD79A) binding protein 1".
3. Chen GI, Tisayakorn S, Jorgensen C, D'Ambrosio LM, Goudreault M, Gingras AC (Oct 2008). "PP4R4/KIAA1622 forms a novel stable cytosolic complex with phosphoprotein phosphatase 4". The Journal of Biological Chemistry 283 (43): 29273–84. doi:10.1074/jbc.M803443200. PMC 2662017. PMID 18715871.
4. Gingras AC, Caballero M, Zarske M, Sanchez A, Hazbun TR, Fields S, Sonenberg N, Hafen E, Raught B, Aebersold R (Nov 2005). "A novel, evolutionarily conserved protein phosphatase complex involved in cisplatin sensitivity". Molecular & Cellular Proteomics 4 (11): 1725–40. doi:10.1074/mcp.M500231-MCP200. PMID 16085932.
5. Chen J, Peterson RT, Schreiber SL (Jun 1998). "Alpha 4 associates with protein phosphatases 2A, 4, and 6". Biochemical and Biophysical Research Communications 247 (3): 827–32. doi:10.1006/bbrc.1998.8792. PMID 9647778.
6. Goudreault M, D'Ambrosio LM, Kean MJ, Mullin MJ, Larsen BG, Sanchez A, Chaudhry S, Chen GI, Sicheri F, Nesvizhskii AI, Aebersold R, Raught B, Gingras AC (Jan 2009). "A PP2A phosphatase high density interaction network identifies a novel striatin-interacting phosphatase and kinase complex linked to the cerebral cavernous malformation 3 (CCM3) protein". Molecular & Cellular Proteomics 8 (1): 157–71. doi:10.1074/mcp.M800266-MCP200. PMC 2621004. PMID 18782753.
7. Chung H, Nairn AC, Murata K, Brautigan DL (Aug 1999). "Mutation of Tyr307 and Leu309 in the protein phosphatase 2A catalytic subunit favors association with the alpha 4 subunit which promotes dephosphorylation of elongation factor-2". Biochemistry 38 (32): 10371–6. doi:10.1021/bi990902g. PMID 10441131.

Further reading

• Chen J, Peterson RT, Schreiber SL (Jun 1998). "Alpha 4 associates with protein phosphatases 2A, 4, and 6". Biochemical and Biophysical Research Communications 247 (3): 827–32. doi:10.1006/bbrc.1998.8792. PMID 9647778.
• Chung H, Nairn AC, Murata K, Brautigan DL (Aug 1999). "Mutation of Tyr307 and Leu309 in the protein phosphatase 2A catalytic subunit favors association with the alpha 4 subunit which promotes dephosphorylation of elongation factor-2". Biochemistry 38 (32): 10371–6. doi:10.1021/bi990902g. PMID 10441131.
• Scanlan MJ, Gordan JD, Williamson B, Stockert E, Bander NH, Jongeneel V, Gure AO, Jäger D, Jäger E, Knuth A, Chen YT, Old LJ (Nov 1999). "Antigens recognized by autologous antibody in patients with renal-cell carcinoma". International Journal of Cancer. Journal International Du Cancer 83 (4): 456–64. doi:10.1002/(SICI)1097-0215(19991112)83:4<456::AID-IJC4>3.0.CO;2-5. PMID 10508479.
• Liu J, Prickett TD, Elliott E, Meroni G, Brautigan DL (Jun 2001). "Phosphorylation and microtubule association of the Opitz syndrome protein mid-1 is regulated by protein phosphatase 2A via binding to the regulatory subunit alpha 4". Proceedings of the National Academy of Sciences of the United States of America 98 (12): 6650–5. doi:10.1073/pnas.111154698. PMC 34408. PMID 11371618.
• Short KM, Hopwood B, Yi Z, Cox TC (2002). "MID1 and MID2 homo- and heterodimerise to tether the rapamycin-sensitive PP2A regulatory subunit, alpha 4, to microtubules: implications for the clinical variability of X-linked Opitz GBBB syndrome and other developmental disorders". BMC Cell Biology 3: 1. doi:10.1186/1471-2121-3-1. PMC 64779. PMID 11806752.
• Graham JM, Wheeler P, Tackels-Horne D, Lin AE, Hall BD, May M, Short KM, Schwartz CE, Cox TC (Nov 2003). "A new X-linked syndrome with agenesis of the corpus callosum, mental retardation, coloboma, micrognathia, and a mutation in the Alpha 4 gene at Xq13". American Journal of Medical Genetics. Part A 123A (1): 37–44. doi:10.1002/ajmg.a.20504. PMID 14556245.
• Smetana JH, Oliveira CL, Jablonka W, Aguiar Pertinhez T, Carneiro FR, Montero-Lomeli M, Torriani I, Zanchin NI (Apr 2006). "Low resolution structure of the human alpha4 protein (IgBP1) and studies on the stability of alpha4 and of its yeast ortholog Tap42". Biochimica et Biophysica Acta 1764 (4): 724–34. doi:10.1016/j.bbapap.2006.01.018. PMID 16517231.