PPP4C

Protein phosphatase 4, catalytic subunit
Identifiers
Symbols	PPP4C ; PP-X; PP4; PP4C; PPH3; PPP4; PPX
External IDs	OMIM: 602035 MGI: 1891763 HomoloGene: 2038 GeneCards: PPP4C Gene
EC number	3.1.3.16
Gene ontology Molecular function • NF-kappaB-inducing kinase activity • protein serine/threonine phosphatase activity • protein binding • lamin binding • protein complex binding • metal ion binding Cellular component • nucleus • nucleoplasm • cytoplasm • microtubule organizing center • plasma membrane • protein phosphatase 4 complex Biological process • protein dephosphorylation • regulation of double-strand break repair via homologous recombination • NIK/NF-kappaB signaling • cellular response to interleukin-1 Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	5531	56420
Ensembl	ENSG00000149923	ENSMUSG00000030697
UniProt	P60510	P97470
RefSeq (mRNA)	NM_001303503	NM_019674
RefSeq (protein)	NP_001290432	NP_062648
Location (UCSC)	Chr 16: 30.08 – 30.09 Mb	Chr 7: 126.79 – 126.79 Mb
PubMed search

Serine/threonine-protein phosphatase 4 catalytic subunit is an enzyme that in humans is encoded by the PPP4C gene.^[1][2]

Interactions

PPP4C has been shown to interact with:

• CCDC6,^[3][4]
• CCT2,^[3][5]
• CCT3,^[3][5]
• CCT4,^[3][5]
• CCT5,^[3][5]
• CCT6A,^[3][5]
• CCT7,^[3][5]
• IGBP1,^[3][5][6]
• PPP2R1A,^[3][4]
• PPP4R1,^[3][5][4]
• REL,^[7]
• SMEK2,^[3][5][4]
• T-complex 1,^[3][5] and
• TRAF6.^[8]

References

1. Bastians H, Krebber H, Hoheisel J, Ohl S, Lichter P, Ponstingl H, Joos S (May 1997). "Assignment of the human serine/threonine protein phosphatase 4 gene (PPP4C) to chromosome 16p11-p12 by fluorescence in situ hybridization". Genomics 42 (1): 181–2. doi:10.1006/geno.1997.4693. PMID 9177794.
2. "Entrez Gene: PPP4C protein phosphatase 4 (formerly X), catalytic subunit".
3. Chen GI, Tisayakorn S, Jorgensen C, D'Ambrosio LM, Goudreault M, Gingras AC (Oct 2008). "PP4R4/KIAA1622 forms a novel stable cytosolic complex with phosphoprotein phosphatase 4". The Journal of Biological Chemistry 283 (43): 29273–84. doi:10.1074/jbc.M803443200. PMC 2662017. PMID 18715871.
4. Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D. "Large-scale mapping of human protein-protein interactions by mass spectrometry". Molecular Systems Biology 3: 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.
5. Gingras AC, Caballero M, Zarske M, Sanchez A, Hazbun TR, Fields S, Sonenberg N, Hafen E, Raught B, Aebersold R (Nov 2005). "A novel, evolutionarily conserved protein phosphatase complex involved in cisplatin sensitivity". Molecular & Cellular Proteomics 4 (11): 1725–40. doi:10.1074/mcp.M500231-MCP200. PMID 16085932.
6. Chen J, Peterson RT, Schreiber SL (Jun 1998). "Alpha 4 associates with protein phosphatases 2A, 4, and 6". Biochemical and Biophysical Research Communications 247 (3): 827–32. doi:10.1006/bbrc.1998.8792. PMID 9647778.
7. Hu MC, Tang-Oxley Q, Qiu WR, Wang YP, Mihindukulasuriya KA, Afshar R, Tan TH (Dec 1998). "Protein phosphatase X interacts with c-Rel and stimulates c-Rel/nuclear factor kappaB activity". The Journal of Biological Chemistry 273 (50): 33561–5. doi:10.1074/jbc.273.50.33561. PMID 9837938.
8. Chen L, Dong W, Zou T, Ouyang L, He G, Liu Y, Qi Y (Aug 2008). "Protein phosphatase 4 negatively regulates LPS cascade by inhibiting ubiquitination of TRAF6". FEBS Letters 582 (19): 2843–9. doi:10.1016/j.febslet.2008.07.014. PMID 18634786.

Further reading

• Brewis ND, Cohen PT (Dec 1992). "Protein phosphatase X has been highly conserved during mammalian evolution". Biochimica Et Biophysica Acta 1171 (2): 231–3. doi:10.1016/0167-4781(92)90129-n. PMID 1336397.
• Brewis ND, Street AJ, Prescott AR, Cohen PT (Mar 1993). "PPX, a novel protein serine/threonine phosphatase localized to centrosomes". The EMBO Journal 12 (3): 987–96. PMC 413299. PMID 8384557.
• Kloeker S, Bryant JC, Strack S, Colbran RJ, Wadzinski BE (Oct 1997). "Carboxymethylation of nuclear protein serine/threonine phosphatase X". The Biochemical Journal. 327 ( Pt 2) (Pt 2): 481–6. PMC 1218819. PMID 9359419.
• Chen J, Peterson RT, Schreiber SL (Jun 1998). "Alpha 4 associates with protein phosphatases 2A, 4, and 6". Biochemical and Biophysical Research Communications 247 (3): 827–32. doi:10.1006/bbrc.1998.8792. PMID 9647778.
• Hu MC, Tang-Oxley Q, Qiu WR, Wang YP, Mihindukulasuriya KA, Afshar R, Tan TH (Dec 1998). "Protein phosphatase X interacts with c-Rel and stimulates c-Rel/nuclear factor kappaB activity". The Journal of Biological Chemistry 273 (50): 33561–5. doi:10.1074/jbc.273.50.33561. PMID 9837938.
• Kloeker S, Wadzinski BE (Feb 1999). "Purification and identification of a novel subunit of protein serine/threonine phosphatase 4". The Journal of Biological Chemistry 274 (9): 5339–47. doi:10.1074/jbc.274.9.5339. PMID 10026142.
• Hastie CJ, Carnegie GK, Morrice N, Cohen PT (May 2000). "A novel 50 kDa protein forms complexes with protein phosphatase 4 and is located at centrosomal microtubule organizing centres". The Biochemical Journal. 347 Pt 3 (Pt 3): 845–55. doi:10.1042/0264-6021:3470845. PMC 1221024. PMID 10769191.
• Carnegie GK, Sleeman JE, Morrice N, Hastie CJ, Peggie MW, Philp A, Lamond AI, Cohen PT (May 2003). "Protein phosphatase 4 interacts with the Survival of Motor Neurons complex and enhances the temporal localisation of snRNPs". Journal of Cell Science 116 (Pt 10): 1905–13. doi:10.1242/jcs.00409. PMID 12668731.
• Yeh PY, Yeh KH, Chuang SE, Song YC, Cheng AL (Jun 2004). "Suppression of MEK/ERK signaling pathway enhances cisplatin-induced NF-kappaB activation by protein phosphatase 4-mediated NF-kappaB p65 Thr dephosphorylation". The Journal of Biological Chemistry 279 (25): 26143–8. doi:10.1074/jbc.M402362200. PMID 15073167.
• Mihindukulasuriya KA, Zhou G, Qin J, Tan TH (Nov 2004). "Protein phosphatase 4 interacts with and down-regulates insulin receptor substrate 4 following tumor necrosis factor-alpha stimulation". The Journal of Biological Chemistry 279 (45): 46588–94. doi:10.1074/jbc.M408067200. PMID 15331607.
• Zhou G, Boomer JS, Tan TH (Nov 2004). "Protein phosphatase 4 is a positive regulator of hematopoietic progenitor kinase 1". The Journal of Biological Chemistry 279 (47): 49551–61. doi:10.1074/jbc.M410317200. PMID 15364934.
• Zhang X, Ozawa Y, Lee H, Wen YD, Tan TH, Wadzinski BE, Seto E (Apr 2005). "Histone deacetylase 3 (HDAC3) activity is regulated by interaction with protein serine/threonine phosphatase 4". Genes & Development 19 (7): 827–39. doi:10.1101/gad.1286005. PMC 1074320. PMID 15805470.
• Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.