SMEK2

Protein phosphatase 4, regulatory subunit 3B
Identifiers
Symbols	PPP4R3B ; FLFL2; PP4R3B; PSY2; SMEK2; smk1
External IDs	OMIM: 610352 MGI: 2144474 HomoloGene: 68886 GeneCards: PPP4R3B Gene
Gene ontology Molecular function • binding Cellular component • nucleoplasm • cytoplasm • microtubule organizing center • protein phosphatase 4 complex Biological process • protein dephosphorylation • regulation of lipid metabolic process • positive regulation of gluconeogenesis Sources: Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	57223	104570
Ensembl	ENSG00000275052	ENSMUSG00000020463
UniProt	Q5MIZ7	Q922R5
RefSeq (mRNA)	NM_001122964	NM_134034
RefSeq (protein)	NP_001116436	NP_598795
Location (UCSC)	Chr 2: 55.55 – 55.62 Mb	Chr 11: 29.17 – 29.22 Mb
PubMed search

Serine/threonine-protein phosphatase 4 regulatory subunit 3B is an enzyme that in humans is encoded by the SMEK2 gene.^[1][2][3]

Interactions

SMEK2 has been shown to interact with PPP4C.^[4][5][1]

References

1. Gingras AC, Caballero M, Zarske M, Sanchez A, Hazbun TR, Fields S, Sonenberg N, Hafen E, Raught B, Aebersold R (Nov 2005). "A novel, evolutionarily conserved protein phosphatase complex involved in cisplatin sensitivity". Molecular & Cellular Proteomics 4 (11): 1725–40. doi:10.1074/mcp.M500231-MCP200. PMID 16085932.
2. Chowdhury D, Xu X, Zhong X, Ahmed F, Zhong J, Liao J, Dykxhoorn DM, Weinstock DM, Pfeifer GP, Lieberman J (Jul 2008). "A PP4-phosphatase complex dephosphorylates gamma-H2AX generated during DNA replication". Molecular Cell 31 (1): 33–46. doi:10.1016/j.molcel.2008.05.016. PMC 3242369. PMID 18614045.
3. "Entrez Gene: SMEK2 SMEK homolog 2, suppressor of mek1 (Dictyostelium)".
4. Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Molecular Systems Biology 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.
5. Chen GI, Tisayakorn S, Jorgensen C, D'Ambrosio LM, Goudreault M, Gingras AC (Oct 2008). "PP4R4/KIAA1622 forms a novel stable cytosolic complex with phosphoprotein phosphatase 4". The Journal of Biological Chemistry 283 (43): 29273–84. doi:10.1074/jbc.M803443200. PMC 2662017. PMID 18715871.

Further reading

• Nagase T, Kikuno R, Ishikawa KI, Hirosawa M, Ohara O (Feb 2000). "Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro". DNA Research 7 (1): 65–73. doi:10.1093/dnares/7.1.65. PMID 10718198.
• Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, Böcher M, Blöcker H, Bauersachs S, Blum H, Lauber J, Düsterhöft A, Beyer A, Köhrer K, Strack N, Mewes HW, Ottenwälder B, Obermaier B, Tampe J, Heubner D, Wambutt R, Korn B, Klein M, Poustka A (Mar 2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Research 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
• Kittler R, Putz G, Pelletier L, Poser I, Heninger AK, Drechsel D, Fischer S, Konstantinova I, Habermann B, Grabner H, Yaspo ML, Himmelbauer H, Korn B, Neugebauer K, Pisabarro MT, Buchholz F (Dec 2004). "An endoribonuclease-prepared siRNA screen in human cells identifies genes essential for cell division". Nature 432 (7020): 1036–40. doi:10.1038/nature03159. PMID 15616564.
• Mendoza MC, Du F, Iranfar N, Tang N, Ma H, Loomis WF, Firtel RA (Sep 2005). "Loss of SMEK, a novel, conserved protein, suppresses MEK1 null cell polarity, chemotaxis, and gene expression defects". Molecular and Cellular Biology 25 (17): 7839–53. doi:10.1128/MCB.25.17.7839-7853.2005. PMC 1190274. PMID 16107728.
• Beausoleil SA, Villén J, Gerber SA, Rush J, Gygi SP (Oct 2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nature Biotechnology 24 (10): 1285–92. doi:10.1038/nbt1240. PMID 16964243.
• Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Molecular Systems Biology 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.