PPP4R1

Protein phosphatase 4, regulatory subunit 1
Identifiers
Symbols	PPP4R1 ; MEG1; PP4(Rmeg); PP4R1
External IDs	OMIM: 604908 HomoloGene: 81737 GeneCards: PPP4R1 Gene
Gene ontology Molecular function • phosphoprotein phosphatase activity • protein binding • protein phosphatase type 4 regulator activity Cellular component • protein phosphatase 4 complex Biological process • protein phosphorylation • protein dephosphorylation • signal transduction • regulation of catalytic activity Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	9989	70351
Ensembl	ENSG00000154845	ENSMUSG00000061950
UniProt	Q8TF05	Q8K2V1
RefSeq (mRNA)	NM_001042388	NM_001114131
RefSeq (protein)	NP_001035847	NP_001107603
Location (UCSC)	Chr 18: 9.55 – 9.62 Mb	Chr 17: 65.78 – 65.84 Mb
PubMed search

Serine/threonine-protein phosphatase 4 regulatory subunit 1 is an enzyme that in humans is encoded by the PPP4R1 gene.^[1][2]

Interactions

PPP4R1 has been shown to interact with PPP4C.^[3][4][5]

References

1. Kloeker S, Wadzinski BE (Feb 1999). "Purification and identification of a novel subunit of protein serine/threonine phosphatase 4". The Journal of Biological Chemistry 274 (9): 5339–47. doi:10.1074/jbc.274.9.5339. PMID 10026142.
2. "Entrez Gene: PPP4R1 protein phosphatase 4, regulatory subunit 1".
3. Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Molecular Systems Biology 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.
4. Chen GI, Tisayakorn S, Jorgensen C, D'Ambrosio LM, Goudreault M, Gingras AC (Oct 2008). "PP4R4/KIAA1622 forms a novel stable cytosolic complex with phosphoprotein phosphatase 4". The Journal of Biological Chemistry 283 (43): 29273–84. doi:10.1074/jbc.M803443200. PMC 2662017. PMID 18715871.
5. Gingras AC, Caballero M, Zarske M, Sanchez A, Hazbun TR, Fields S, Sonenberg N, Hafen E, Raught B, Aebersold R (Nov 2005). "A novel, evolutionarily conserved protein phosphatase complex involved in cisplatin sensitivity". Molecular & Cellular Proteomics 4 (11): 1725–40. doi:10.1074/mcp.M500231-MCP200. PMID 16085932.

Further reading

• Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Molecular Systems Biology 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.
• Zhang X, Ozawa Y, Lee H, Wen YD, Tan TH, Wadzinski BE, Seto E (Apr 2005). "Histone deacetylase 3 (HDAC3) activity is regulated by interaction with protein serine/threonine phosphatase 4". Genes & Development 19 (7): 827–39. doi:10.1101/gad.1286005. PMC 1074320. PMID 15805470.
• Wada T, Miyata T, Inagi R, Nangaku M, Wagatsuma M, Suzuki D, Wadzinski BE, Okubo K, Kurokawa K (Dec 2001). "Cloning and characterization of a novel subunit of protein serine/threonine phosphatase 4 from mesangial cells". Journal of the American Society of Nephrology 12 (12): 2601–8. PMID 11729228.
• Yu W, Andersson B, Worley KC, Muzny DM, Ding Y, Liu W, Ricafrente JY, Wentland MA, Lennon G, Gibbs RA (Apr 1997). "Large-scale concatenation cDNA sequencing". Genome Research 7 (4): 353–8. doi:10.1101/gr.7.4.353. PMC 139146. PMID 9110174.
• Andersson B, Wentland MA, Ricafrente JY, Liu W, Gibbs RA (Apr 1996). "A "double adaptor" method for improved shotgun library construction". Analytical Biochemistry 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474.