IKZF4

IKAROS family zinc finger 4 (Eos)
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 2MA7​
Identifiers
Symbols	IKZF4 ; EOS; ZNFN1A4
External IDs	OMIM: 606239 MGI: 1343139 HomoloGene: 69103 GeneCards: IKZF4 Gene
Gene ontology Molecular function • transcription factor activity, sequence-specific DNA binding • protein homodimerization activity • bHLH transcription factor binding • sequence-specific DNA binding • metal ion binding • protein heterodimerization activity Cellular component • nucleus Biological process • transcription, DNA-templated • negative regulation of transcription, DNA-templated • positive regulation of transcription from RNA polymerase II promoter Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	64375	22781
Ensembl	ENSG00000123411	ENSMUSG00000002578
UniProt	Q9H2S9	Q8C208
RefSeq (mRNA)	NM_022465	NM_011772
RefSeq (protein)	NP_071910	NP_035902
Location (UCSC)	Chr 12: 56.01 – 56.04 Mb	Chr 10: 128.63 – 128.65 Mb
PubMed search

Zinc finger protein Eos is a protein that in humans is encoded by the IKZF4 gene.^[1][2]

Members of the Ikaros (ZNFN1A1; MIM 603023) family of transcription factors, which includes Eos, are expressed in lymphocytes and are implicated in the control of lymphoid development.[supplied by OMIM]^[2]

Interactions

IKZF4 has been shown to interact with CTBP1^[3] and IKZF1.^[1][4]

References

1. Perdomo J, Holmes M, Chong B, Crossley M (Jan 2001). "Eos and pegasus, two members of the Ikaros family of proteins with distinct DNA binding activities". J Biol Chem 275 (49): 38347–54. doi:10.1074/jbc.M005457200. PMID 10978333.
2. "Entrez Gene: IKZF4 IKAROS family zinc finger 4 (Eos)".
3. Perdomo, José; Crossley Merlin (Dec 2002). "The Ikaros family protein Eos associates with C-terminal-binding protein corepressors". Eur. J. Biochem. (Germany) 269 (23): 5885–92. doi:10.1046/j.1432-1033.2002.03313.x. ISSN 0014-2956. PMID 12444977.
4. Honma, Y; Kiyosawa H; Mori T; Oguri A; Nikaido T; Kanazawa K; Tojo M; Takeda J; Tanno Y; Yokoya S; Kawabata I; Ikeda H; Wanaka A (Mar 1999). "Eos: a novel member of the Ikaros gene family expressed predominantly in the developing nervous system". FEBS Lett. (NETHERLANDS) 447 (1): 76–80. doi:10.1016/S0014-5793(99)00265-3. ISSN 0014-5793. PMID 10218586.

Further reading

• Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
• Bao J, Lin H, Ouyang Y, et al. (2005). "Activity-dependent transcription regulation of PSD-95 by neuregulin-1 and Eos". Nat. Neurosci. 7 (11): 1250–8. doi:10.1038/nn1342. PMID 15494726.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Perdomo J, Crossley M (2003). "The Ikaros family protein Eos associates with C-terminal-binding protein corepressors". Eur. J. Biochem. 269 (23): 5885–92. doi:10.1046/j.1432-1033.2002.03313.x. PMID 12444977.
• Koipally J, Georgopoulos K (2002). "A molecular dissection of the repression circuitry of Ikaros". J. Biol. Chem. 277 (31): 27697–705. doi:10.1074/jbc.M201694200. PMID 12015313.
• Nagase T, Nakayama M, Nakajima D, et al. (2001). "Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 8 (2): 85–95. doi:10.1093/dnares/8.2.85. PMID 11347906.
• Honma Y, Kiyosawa H, Mori T, et al. (1999). "Eos: a novel member of the Ikaros gene family expressed predominantly in the developing nervous system". FEBS Lett. 447 (1): 76–80. doi:10.1016/S0014-5793(99)00265-3. PMID 10218586.