Cervical incompetence

Cervical insufficiency
Classification and external resources
Specialty	urology
ICD-10	N88.3 O34.3
ICD-9-CM	622.5
DiseasesDB	2292
MeSH	D002581

Cervical incompetence (or cervical insufficiency) is a medical condition in which a pregnant woman's cervix begins to dilate (widen) and efface (thin) before her pregnancy has reached term. Definitions of cervical incompetence vary, but one that is frequently used is the inability of the uterine cervix to retain a pregnancy in the absence of the signs and symptoms of clinical contractions, or labor, or both in the second trimester.^[1] Cervical incompetence may cause miscarriage or preterm birth during the second and third trimesters. Another sign of cervical incompetence is funneling at the internal orifice of the uterus, which is a dilation of the cervical canal at this location.^[2]

In a woman with cervical incompetence, dilation and effacement of the cervix may occur without pain or uterine contractions. In a normal pregnancy, dilation and effacement occurs in response to uterine contractions. Cervical incompetence occurs because of weakness of the cervix, which is made to open by the growing pressure in the uterus as pregnancy progresses. If the responses are not halted, rupture of the membranes and birth of a premature baby can result.

According to statistics provided by the Mayo Clinic, cervical incompetence is relatively rare in the United States, occurring in only 1–2% of all pregnancies, but it is thought to cause as many as 20—25% of miscarriages in the second trimester.

Diagnosis

Diagnosis of cervical incompetence can be challenging and is based on a history of painless cervical dilation usually after the first trimester without contractions or labor and in the absence of other clear pathology. In addition to history, some providers use assessment of cervical length in second trimester to identify cervical shortening using ultrasound.^[3] However, short cervical length has actually been shown to be a marker of preterm birth rather than cervical incompetence. Other diagnostic tests that have been suggested which have not been validated include hysterosalpingography and radiographic imaging of balloon traction on the cervix, assessment of the patulous cervix with Hegar or Pratt dilators, the use of a balloon elastance test, and use of graduated cervical dilators to calculate a cervical resistance index.^[1]

Normally, the cervix should be at least 30 mm in length. Cervical incompetence is variably defined. However, a common definition is a cervical length of less than 25 mm at or before 24 weeks of gestational age. The risk of preterm birth is inversely proportional to cervical length:^[4]

• Less than 25 mm; 18% risk of preterm birth
• Less than 20 mm; 25% risk of preterm birth
• Less than 15 mm; 50% risk of preterm birth

Risk factors

Risk factors for premature birth or stillbirth due to cervical incompetence include:^[5]

• diagnosis of cervical incompetence in a previous pregnancy,
• previous preterm premature rupture of membranes,
• history of conization (cervical biopsy),
• diethylstilbestrol exposure, which can cause anatomical defects, and
• uterine anomalies.

Repeated procedures (such as mechanical dilation, especially during late pregnancy) appear to create a risk.^[6] Additionally, any significant trauma to the cervix can weaken the tissues involved.

Treatment

Cervical incompetence is not generally treated except when it appears to threaten a pregnancy. Cervical incompetence can be treated using cervical cerclage, a surgical technique that reinforces the cervical muscle by placing sutures above the opening of the cervix to narrow the cervical canal.

Cerclage procedures usually entail closing the cervix through the vagina with the aid of a speculum. Another approach involves performing the cerclage through an abdominal incision. Transabdominal cerclage of the cervix makes it possible to place the stitch exactly at the level that is needed. It can be carried out when the cervix is very short, effaced or totally distorted. Cerclages are usually performed between weeks 14 and 16 of the pregnancy. The sutures are removed between weeks 36 and 38 to avoid problems during labor. The complications described in the literature have been rare: hemorrhage from damage to the veins at the time of the procedure; and fetal death due to uterine vessels occlusion.

No significant differences in pregnancy outcomes were found in a study evaluating pregnancy outcomes after cervical conization. This study suggests for women with cervical insufficiency due to prior cone biopsy, cerclage is not superior to no intervention.^[7] As cerclage can induce preterm contractions without preventing premature delivery,^[8] makes the recommendation that it be used sparingly in women with a history of conization.

A cervical pessary is being studied as an alternative to cervical cerclage since there are fewer potential complications. A silicone ring is placed at the opening to the cervix early in the pregnancy, and removed later in the pregnancy prior to the time of expected delivery. Further study is needed to determine whether a cervical pessary is equal or superiour to current management.^[9]

Notes

1. American College of Obstetricians and, Gynecologists (Feb 2014). "ACOG Practice Bulletin No.142: Cerclage for the management of cervical insufficiency.". Obstetrics and gynecology 123 (2 Pt 1): 372–9. doi:10.1097/01.AOG.0000443276.68274.cc. PMID 24451674.
2. Cervical assessment from Fetal Medicine Foundation. Retrieved Feb 2014.
3. Macdonald, R; Smith, P; Vyas, S (Sep 2001). "Cervical incompetence: the use of transvaginal sonography to provide an objective diagnosis.". Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology 18 (3): 211–6. doi:10.1046/j.1469-0705.2001.00459.x. PMID 11555448.
4. Cervical incompetence at Radiopedia. By Dr Praveen Jha and Dr Laughlin Dawes et al. Retrieved June 2014
5. Althuisius SM, Dekker GA, Hummel P, Bekedam DJ & van Geijn HP (Nov 2001). "Final results of the Cervical Incompetence Prevention Randomized Cerclage Trial (CIPRACT): therapeutic cerclage with bed rest versus bed rest alone.". American Journal of Obstetrics & Gynecology (Academic Press) 185 (5): 1106–1112. doi:10.1067/mob.[phone]. PMID 11717642.
6. "Cervical Incompetence – Protocol for Management" (PDF). PROTOCOL #40. Maternal Fetal Medicine, University of New Mexico. 2012-03-03.
7. Armarnik, S; Sheiner, E; Piura, B; Meirovitz, M; Zlotnik, A; Levy, A (April 2011). "Obstetric outcome following cervical conization.". Archives of gynecology and obstetrics 283 (4): 765–9. doi:10.1007/s00404-011-1848-3. PMID 21327802.
8. Zeisler, H; Joura, EA; Bancher-Todesca, D; Hanzal, E; Gitsch, G (July 1997). "Prophylactic cerclage in pregnancy. Effect in women with a history of conization.". The Journal of reproductive medicine 42 (7): 390–2. PMID 9252928.
9. Abdel-Aleem, H; Shaaban, OM; Abdel-Aleem, MA (May 31, 2013). "Cervical pessary for preventing preterm birth.". The Cochrane database of systematic reviews 5: CD007873. doi:10.1002/14651858.CD007873.pub3. PMID 23728668.

References

• The first revision of this article was adapted from material from the public domain source "Summary Report: ICD-9-CM coordination and maintenance committee", published at http://www.cms.hhs.gov/paymentsystems/icd9/icd111700.pdf.