Isocitrate epimerase

isocitrate epimerase
Identifiers
EC number	5.1.2.6
CAS number	81210-68-6
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / EGO
Search PMC articles PubMed articles NCBI proteins

In enzymology, an isocitrate epimerase (EC 5.1.2.6) is an enzyme that catalyzes the chemical reaction

(1R,2S)-1-hydroxypropane-1,2,3-tricarboxylate $\rightleftharpoons$ (1S,2S)-1-hydroxypropane-1,2,3-tricarboxylate

Hence, this enzyme has one substrate, (1R,2S)-1-hydroxypropane-1,2,3-tricarboxylate, and one product, (1S,2S)-1-hydroxypropane-1,2,3-tricarboxylate.

This enzyme belongs to the family of isomerases, specifically those racemases and epimerases acting on hydroxy acids and derivatives. The systematic name of this enzyme class is (1R,2S)-1-hydroxypropane-1,2,3-tricarboxylate 1-epimerase.

References

• Hoshiko S, Kunimoto Y, Arima K and Beppu T (1982). "Mechanism of L-alloisocitric acid fermentation: isocitrate epimerase activity in the cell-free-extract of Penicillium purpurogenum". Agric. Biol. Chem. 46: 143–151. doi:10.1271/bbb1961.46.143.