Limonene-1,2-diol dehydrogenase

Limonene-1,2-diol dehydrogenase
Identifiers
EC number	1.1.1.297
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Search PMC articles PubMed articles NCBI proteins

Limonene-1,2-diol dehydrogenase (EC 1.1.1.297, NAD⁺-dependent limonene-1,2-diol dehydrogenase) is an enzyme with systematic name menth-8-ene-1,2-diol:NAD⁺ oxidoreductase.^[1] This enzyme catalyses the following chemical reaction

menth-8-ene-1,2-diol + NAD⁺ $\rightleftharpoons$ 1-hydroxymenth-8-en-2-one + NADH + H⁺ (general reaction)

(1) (1S,2S,4R)-menth-8-ene-1,2-diol + NAD⁺ $\rightleftharpoons$ (1S,4R)-1-hydroxymenth-8-en-2-one + NADH + H⁺

(2) (1R,2R,4S)-menth-8-ene-1,2-diol + NAD⁺ $\rightleftharpoons$ (1R,4S)-1-hydroxymenth-8-en-2-one + NADH + H⁺

While the enzyme from the Gram-positive bacterium Rhodococcus erythropolis DCL14 can use both (1S,2S,4R)- and (1R,2R,4S)-menth-8-ene-1,2-diol as substrate, activity is higher with (1S,2S,4R)-menth-8-ene-1,2-diol as substrate.

References

1. van der Werf, M.J., Swarts, H.J. and de Bont, J.A. (1999). "Rhodococcus erythropolis DCL14 contains a novel degradation pathway for limonene". Appl. Environ. Microbiol. 65 (5): 2092–2102. PMC 91303. PMID 10224006.

External links

• Limonene-1,2-diol dehydrogenase at the US National Library of Medicine Medical Subject Headings (MeSH)