| Name | City | Hospital beds | Operating rooms | Trauma designation | Affiliation | Notes |
| Alamance Regional Medical Center | Burlington | 238 | 15 | - | CHS[1] | - |
| Alleghany Memorial Hospital | Sparta | 41 | 2 | - | Alliant | - |
| Angel Medical Center | Franklin | 59 | 7 | - | Mission | - |
| Annie Penn Hospital | Reidsville | 110 | 6 | - | CHS[2] | - |
| Ashe Memorial Hospital | Jefferson | 136 | 3 | - | Novant | - |
| Asheville Specialty Hospital | Asheville | 34 | 0 | - | Mission | - |
| Betsy Johnson Regional Hospital | Dunn | 101 | 6 | - | HHS | - |
| Blue Ridge Regional Hospital | Spruce Pine | 46 | 4 | - | Mission | - |
| Caldwell UNC Health Care | Lenoir | 110 | 10 | - | UNC | - |
| Cape Fear Valley-Bladen County Hospital | Elizabethtown | 58 | 2 | - | Cape Fear | - |
| Cape Fear Valley Hoke Hospital | Raeford | 41 | 3 | - | Cape Fear | - |
| Cape Fear Valley Medical Center | Fayetteville | 600 | 22 | Level III | Cape Fear | - |
| CarePartners Rehabilitation Hospital | Asheville | 80 | 0 | - | - | - |
| CarolinaEast Medical Center | New Bern | 350 | 20 | - | - | - |
| Carolinas ContinueCARE Hospital at Kings Mountain | Kings Mountain | 28 | - | - | CHS | - |
| Carolinas ContinueCARE Hospital at Pineville | Charlotte | 40 | 0 | - | CHS | - |
| Carolinas HealthCare System Anson | Wadesboro | 15 | 1 | - | CHS | - |
| Carolinas HealthCare System Blue Ridge Morganton | Morganton | 315 | 13 | - | CHS | count includes CHS Blue Ridge Valdese facility |
| Carolinas HealthCare System Cleveland | Shelby | 241 | 11 | Level III | CHS | - |
| Carolinas HealthCare System Kings Mountain | Kings Mountain | 67 | 3 | - | CHS | - |
| Carolinas HealthCare System Lincoln | Lincolnton | 101 | 7 | - | CHS | - |
| Carolinas HealthCare System NorthEast | Concord | 457 | 27 | Level III | CHS | count includes the Jeff Gordon Children's Hospital, as well as CHS Kannapolis and CHS Harrisburg |
| Carolinas HealthCare System Pineville | Charlotte | 235 | 7 | - | CHS | count includes CHS Steele Creek |
| Carolinas HealthCare System Union | Monroe | 175 | 10 | - | CHS | counts include CHS Waxhaw; counts do not include 70 nursing home beds in the Jesse Helms Nursing Center |
| Carolinas HealthCare System University | Charlotte | 94 | 13 | - | CHS | counts include CMC Huntersville |
| Carolinas Medical Center/Center for Mental Health | Charlotte | 1132 | 74 | Level I | CHS | Secondary campus of the University of North Carolina School of Medicine; counts include the Levine Children's Hospital, CHS Behavioral Health, CMC-Mercy, and CHS Southpark |
| Carolinas Rehabilitation | Charlotte | 70 | 0 | - | CHS | - |
| Carolinas Rehabilitation Mt. Holly | Belmont | 40 | 0 | - | CHS | - |
| Carolinas Rehabilitation NorthEast | Concord | 40 | 0 | - | CHS | - |
| CaroMont Regional Medical Center | Gastonia | 435 | 28 | Level III | - | - |
| Carteret Health Care | Morehead City | 135 | 8 | - | - | - |
| Catawba Valley Medical Center | Hickory | 258 | 16 | - | - | - |
| Central Carolina Hospital | Sanford | 137 | 8 | - | Duke LifePoint | - |
| Central Harnett Hospital | Lillington | 50 | 1 | - | HHS | - |
| Charles A. Cannon, Jr. Memorial Hospital | Linville | 50 | 3 | - | ARHS | - |
| Chatham UNC Health Care | Siler City | 25 | 3 | - | UNC | - |
| Columbus Regional Healthcare System | Whiteville | 154 | 7 | - | CHS | - |
| Moses H. Cone Memorial Hospital | Greensboro | 907 | 62 | Level II | CHS[3] | - |
| Davie County Hospital | Mocksville | 81 | 3 | - | WFU | - |
| Davis Regional Medical Center | Statesville | 131 | 8 | - | Community Health | - |
| Dosher Memorial Hospital | Southport | 100 | 4 | - | - | - |
| Duke Raleigh Hospital | Raleigh | 186 | 16 | - | Duke | - |
| Duke University Hospital | Durham | 943 | 59 | Level I | Duke | Primary teaching hospital of Duke University School of Medicine |
| Duke Regional Hospital | Durham | 369 | 19 | - | Duke | - |
| FirstHealth Montgomery Memorial Hospital | Troy | 37 | 2 | - | FirstHealth | - |
| FirstHealth Moore Regional Hospital and Pinehurst Treatment | Pinehurst | 372 | 19 | - | FirstHealth | - |
| FirstHealth Moore Regional Hospital Hoke Campus | Pinehurst, North Carolina | 8 | 1 | - | FirstHealth | - |
| FirstHealth Richmond Memorial Hospital | Rockingham | 150 | 6 | - | FirstHealth | - |
| Frye Regional Medical Center | Hickory | 355 | 23 | - | Duke LifePoint[4] | - |
| Granville Health System | Oxford | 142 | 4 | - | - | - |
| Halifax Regional Medical Center | Roanoke Rapids | 204 | 7 | - | Novant | - |
| Harris Regional Hospital | Sylva | 86 | 7 | - | Duke LifePoint | - |
| Haywood Regional Medical Center | Clyde | 169 | 10 | - | Duke LifePoint | - |
| High Point Regional UNC Health Care | High Point | 384 | 15 | Level III | UNC | - |
| Highlands-Cashiers Hospital | Highlands | 108 | 4 | - | Mission | - |
| Highsmith-Rainey Specialty Hospital | Fayetteville | 66 | 7 | - | Cape Fear | - |
| Hugh Chatham Memorial Hospital | Elkin | 220 | 8 | - | Novant | - |
| Iredell Memorial Hospital | Statesville | 247 | 14 | - | - | - |
| Johnston UNC Health care | Smithfield | 177 | 10 | - | UNC | - |
| Kindred Hospital - Greensboro | Greensboro | 124 | 1 | - | - | - |
| Lake Norman Regional Medical Center | Mooresville | 123 | 11 | - | Community Health | - |
| Lenoir Memorial Hospital | Kinston | 261 | 12 | - | - | - |
| LifeCare Hospitals of North Carolina | Rocky Mount | 50 | 0 | - | LifeCare | - |
| Maria Parham Medical Center | Henderson | 102 | 7 | - | Duke LifePoint | - |
| Martin General Hospital | Williamston | 49 | 3 | - | Community Health | - |
| The McDowell Hospital | Marion | 65 | 4 | - | Mission | - |
| Memorial Mission Hospital and Asheville Surgery Center | Asheville | 730 | 36 | Level II | Mission | - |
| Morehead Memorial Hospital | Eden | 229 | 8 | - | Novant | - |
| Murphy Medical Center | Murphy | 191 | 6 | - | CHS | - |
| Nash UNC Health Care | Rocky Mount | 353 | 18 | - | UNC | - |
| New Hanover Regional Medical Center | Wilmington | 769 | 37 | Level II | NHRMC | - |
| North Carolina Specialty Hospital | Durham | 18 | 4 | - | - | - |
| Northern Hospital of Surry County | Mount Airy | 133 | 7 | - | QHR | - |
| Novant Health Brunswick Medical Center | Supply | 60 | 6 | - | Novant | - |
| Novant Health Charlotte Orthopaedic Hospital | Charlotte | 156 | 12 | - | Novant | - |
| Novant Health Forsyth Medical Center | Winston-Salem | 919 | 38 | - | Novant | - |
| Novant Health Franklin Regional Medical Center | Louisburg | 70 | 4 | - | Novant | - |
| Novant Health Huntersville Medical Center | Huntersville | 60 | 8 | - | Novant | - |
| Novant Health Kernersville Medical Center | Kernersville | 50 | 4 | - | Novant | - |
| Novant Health Matthews Medical Center | Matthews | 102 | 14 | - | Novant | - |
| Novant Health Medical Park Hospital | Winston-Salem | 22 | 13 | - | Novant | - |
| Novant Health Presbyterian Medical Center | Charlotte | 603 | 43 | Level II (practicing)[5] | Novant | - |
| Novant Health Rowan Medical Center | Salisbury | 268 | 17 | - | Novant | - |
| Novant Health Thomasville Medical Center | Thomasville | 149 | 7 | - | Novant | - |
| Onslow Memorial Hospital | Jacksonville | 162 | 13 | - | - | - |
| Our Community Hospital | Scotland Neck | 100 | 0 | - | - | - |
| The Outer Banks Hospital | Nags Head | 21 | 5 | - | Vidant | - |
| Pardee UNC Health Care | Hendersonville | 222 | 13 | - | UNC | - |
| Park Ridge Health | Hendersonville | 103 | 7 | - | - | - |
| Pender Memorial Hospital | Burgaw | 86 | 3 | - | NHRMC | - |
| Person Memorial Hospital | Roxboro | 110 | 5 | - | Duke LifePoint | - |
| Pioneer Community Hospital of Stokes | Danbury | 93 | 5 | - | - | - |
| Randolph Hospital | Asheboro | 145 | 8 | - | - | - |
| UNC REX Healthcare | Raleigh | 665 | 38 | - | UNC | - |
| Rutherford Regional Health System | Rutherfordton | 143 | 7 | - | Duke LifePoint | - |
| Sampson Regional Medical Center | Clinton | 146 | 8 | - | - | - |
| Sandhills Regional Medical Center | Hamlet | 64 | 5 | - | Community Health | - |
| Scotland Memorial Hospital and Edwin Morgan Center | Laurinburg | 104 [6] | 8 | - | CHS | counts do not include 50 nursing home beds in the Edwin Morgan Center |
| Select Specialty Hospital - Durham | Durham | 30 | 0 | - | Select Specialty Hospital | - |
| Select Specialty Hospital - Greensboro | Greensboro | 30 | 0 | - | Select Specialty Hospital | - |
| Select Specialty Hospital - Winston-Salem | Winston-Salem | 42 | 0 | - | Select Specialty Hospital | - |
| Sentara Albemarle Medical Center | Elizabeth City | 182 | 13 | - | Sentara | - |
| Southeastern Regional Medical Center | Lumberton | 452 | 15 | - | - | - |
| St. Luke's Hospital | Columbus | 55 | 3 | - | CHS | - |
| Stanly Regional Medical Center | Albemarle | 119 | 8 | - | CHS | - |
| Swain County Hospital | Bryson City | 48 | 2 | - | Duke LifePoint | - |
| Transylvania Regional Hospital | Brevard | 92 | 6 | - | Mission | - |
| UNC Medical Center | Chapel Hill | 778 | 48 | Level I | UNC | Primary teaching hospital of University of North Carolina at Chapel Hill School of Medicine |
| Vidant Beaufort Hospital | Washington | 142 | 7 | - | Vidant | - |
| Vidant Bertie Hospital | Windsor | 6 | 2 | - | Vidant | - |
| Vidant Chowan Hospital | Edenton | 89 | 4 | - | Vidant | - |
| Vidant Duplin Hospital | Kenansville | 101 | 3 | - | Vidant | - |
| Vidant Edgecombe Hospital | Tarboro | 117 | 8 | - | Vidant | - |
| Vidant Medical Center | Greenville | 909 | 35 | Level I | Vidant | Primary teaching hospital of East Carolina University Brody School of Medicine |
| Vidant Roanoke-Chowan Hospital | Ahoskie | 114 | 7 | - | Vidant | - |
| Wake Forest Baptist Health - Lexington Medical Center | Lexington | 94 | 6 | - | WFU | - |
| Wake Forest Baptist Medical Center | Winston-Salem | 885 | 50 | Level I | WFU | Primary teaching hospital of Wake Forest School of Medicine |
| WakeMed | Raleigh | 618 | 35 | Level I | WakeMed | - |
| WakeMed Cary Hospital | Cary | 192 | 15 | - | WakeMed | - |
| Washington County Hospital | Plymouth | 49 | 2 | - | Rural Community Hospitals of America | - |
| Watauga Medical Center | Boone | 117 | 9 | - | ARHS | - |
| Wayne Memorial Hospital | Goldsboro | 316 | 15 | - | - | - |
| Wilkes Regional Medical Center | North Wilkesboro | 144 | 9 | - | CHS | - |
| Wilson Medical Center | Wilson | 294 | 15 | - | Duke LifePoint | - |
| Yadkin Valley Community Hospital | Yadkinville | | | - | - | Closed in 2015, no immediate plans to reopen |
