List of number-one R&B singles of 2001 (U.S.)
These are the Billboard R&B singles chart number-one singles of 2001.
Chart history
| Issue Date | Song | Artist |
| January 6 | "Independent Women Part I" | Destiny's Child |
| January 13 | "I Just Wanna Luv U (Give It 2 Me)" | Jay-Z |
| January 20 | "I Just Wanna Luv U (Give It 2 Me)" | Jay-Z |
| January 27 | "Danger (Been So Long)" | Mystikal featuring Nivea |
| February 3 | "Ms. Jackson" | OutKast |
| February 10 | "Stutter" | Joe featuring Mystikal |
| February 17 | "Stutter" | Joe featuring Mystikal |
| February 24 | "Stutter" | Joe featuring Mystikal |
| March 3 | "Stutter" | Joe featuring Mystikal |
| March 10 | "Stutter" | Joe featuring Mystikal |
| March 17 | "It's Over Now" | 112 |
| March 24 | "It's Over Now" | 112 |
| March 31 | "Promise" | Jagged Edge |
| April 7 | "Promise" | Jagged Edge |
| April 14 | "All for You" | Janet |
| April 21 | "All for You" | Janet |
| April 28 | "Missing You" | Case |
| May 5 | "Missing You" | Case |
| May 12 | "Missing You" | Case |
| May 19 | "Missing You" | Case |
| May 26 | "My Baby" | Lil' Romeo |
| June 2 | "Fiesta" | R. Kelly featuring Jay-Z |
| June 9 | "Fiesta" | R. Kelly featuring Jay-Z |
| June 16 | "Fiesta" | R. Kelly featuring Jay-Z |
| June 23 | "Fiesta" | R. Kelly featuring Jay-Z |
| June 30 | "Fiesta" | R. Kelly featuring Jay-Z |
| July 7 | "U Remind Me" | Usher |
| July 14 | "U Remind Me" | Usher |
| July 21 | "U Remind Me" | Usher |
| July 28 | "U Remind Me" | Usher |
| August 4 | "Loverboy" | Mariah Carey featuring Cameo |
| August 11 | "Loverboy" | Mariah Carey featuring Cameo |
| August 18 | "Fallin'" | Alicia Keys |
| August 25 | "Fallin'" | Alicia Keys |
| September 1 | "Fallin'" | Alicia Keys |
| September 8 | "Fallin'" | Alicia Keys |
| September 15 | "Where the Party At" | Jagged Edge with Nelly |
| September 22 | "Where the Party At" | Jagged Edge with Nelly |
| September 29 | "Where the Party At" | Jagged Edge with Nelly |
| October 6 | "Differences" | Ginuwine |
| October 13 | "Differences" | Ginuwine |
| October 20 | "Differences" | Ginuwine |
| October 27 | "Differences" | Ginuwine |
| November 3 | "Family Affair" | Mary J. Blige |
| November 10 | "Family Affair" | Mary J. Blige |
| November 17 | "U Got It Bad" | Usher |
| November 24 | "U Got It Bad" | Usher |
| December 1 | "U Got It Bad" | Usher |
| December 8 | "U Got It Bad" | Usher |
| December 15 | "U Got It Bad" | Usher |
| December 22 | "U Got It Bad" | Usher |
| December 29 | "U Got It Bad" | Usher |
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See also
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| | 1942–1959 | |
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| | 1960–1979 | |
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| | 1980–1999 | |
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| | 2000–present | |
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