Lomustine

Lomustine

Systematic (IUPAC) name
N-(2-chloroethyl)-N'-cyclohexyl-N-nitrosourea
Clinical data
Trade names	CeeNU
AHFS/Drugs.com	monograph
MedlinePlus	a682207
Pregnancy category	D
Routes of administration	Oral
Legal status	℞ (Prescription only)
Pharmacokinetic data
Bioavailability	~100%
Protein binding	50%
Metabolism	hepatic
Biological half-life	16–48 hours
Identifiers
CAS Number	13010-47-4
ATC code	L01AD02 (WHO)
PubChem	CID 3950
IUPHAR/BPS	7214
DrugBank	DB01206
ChemSpider	3813
UNII	7BRF0Z81KG
KEGG	D00363
ChEBI	CHEBI:6520
ChEMBL	CHEMBL514
Synonyms	1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea
Chemical data
Formula	C9H16ClN3O2
Molar mass	233.695 g/mol
SMILES O=C(NC1CCCCC1)N(N=O)CCCl
InChI InChI=1S/C9H16ClN3O2/c10-6-7-13(12-15)9(14)11-8-4-2-1-3-5-8/h8H,1-7H2,(H,11,14) Key:GQYIWUVLTXOXAJ-UHFFFAOYSA-N
Physical data
Melting point	90 °C (194 °F)
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Lomustine (INN), also called 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea (CCNU) (trade name CeeNU in the U.S.) is an alkylating nitrosourea compound used in chemotherapy. It is closely related to semustine and is in the same family as streptozotocin. It is a highly lipid-soluble drug and thus crosses the blood-brain barrier. This property makes it ideal for treating brain tumors, which is its primary use. Lomustine has a long time to nadir (the time when white blood cells reach their lowest number).

References

External links

• CeeNu (lomustine) Capsules data sheet published by the FDA
• Lomustine at the US National Library of Medicine Medical Subject Headings (MeSH)
• Patient information at cancerbackup.org.uk
• DDB 29525