Ranimustine

Ranimustine

Systematic (IUPAC) name
methyl 6-({[(2-chloroethyl)(nitroso)amino]carbonyl}amino)-6-deoxy-α-D-glucopyranoside
Clinical data
AHFS/Drugs.com	International Drug Names
Routes of administration	IV
Legal status	℞ (Prescription only)
Identifiers
CAS Number	58994-96-0
ATC code	L01AD07 (WHO)
PubChem	CID 71741
ChemSpider	64785
UNII	RYH2T97J77
Synonyms	1-(2-chloroethyl)-1-nitroso-3-([(2R,3S,4S,5R,6S)-3,4,5-trihydroxy-6-methoxyoxan-2-yl]methyl)urea
Chemical data
Formula	C10H18ClN3O7
Molar mass	327.71 g/mol
SMILES CO[C@@H]1[C@@H]([C@H]([C@@H]([C@H](O1)CNC(=O)N(CCCl)N=O)O)O)O
InChI InChI=1S/C10H18ClN3O7/c1-20-9-8(17)7(16)6(15)5(21-9)4-12-10(18)14(13-19)3-2-11/h5-9,15-17H,2-4H2,1H3,(H,12,18)/t5-,6-,7+,8-,9+/m1/s1 Key:AHHFEZNOXOZZQA-ZEBDFXRSSA-N
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Ranimustine (INN, marketed under the tradename Cymerin; also known as MCNU) is a nitrosourea alkylating agent approved in Japan for the treatment of chronic myelogenous leukemia^[1] and polycythemia vera.^[2]

It has never been filed for FDA evaluation in the United States, where it is not marketed.

References

1. Kitajima K, Adachi T, Takahashi I, et al. (November 1989). "[Chemotherapy of chronic myelogenous leukemia--VP(M) regimen initiated during its chronic phase, and evaluation of MCNU in the phase of blastic crisis]". Gan To Kagaku Ryoho (in Japanese) 16 (11): 3573–9. PMID 2817908.
2. Nagai M, Tasaka T, Kamano H, et al. (December 1988). "[Therapeutic effect of ranimustine (MCNU) on essential thrombocythemia and polycythemia vera]". Gan To Kagaku Ryoho (in Japanese) 15 (12): 3267–70. PMID 3196045.

• (Japanese) Cymerin サイメリン (PDF) Mitsubishi Tanabe Pharma. October 2007.