MAP1B

Microtubule-associated protein 1B
Identifiers
Symbols	MAP1B ; FUTSCH; MAP5; PPP1R102
External IDs	OMIM: 157129 MGI: 1306778 HomoloGene: 38111 GeneCards: MAP1B Gene
Gene ontology Molecular function • structural molecule activity • protein binding • microtubule binding Cellular component • photoreceptor outer segment • cytoplasm • cytosol • microtubule • microtubule associated complex • plasma membrane • cell junction • dendritic spine • neuronal postsynaptic density Biological process • microtubule bundle formation • cellular process • dendrite development • negative regulation of intracellular transport • positive regulation of axon extension • mitochondrion transport along microtubule • axon extension • establishment of monopolar cell polarity Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	4131	17755
Ensembl	ENSG00000131711	ENSMUSG00000052727
UniProt	P46821	P14873
RefSeq (mRNA)	NM_005909	NM_008634
RefSeq (protein)	NP_005900	NP_032660
Location (UCSC)	Chr 5: 72.11 – 72.21 Mb	Chr 13: 99.42 – 99.52 Mb
PubMed search

Microtubule-associated protein 1B is a protein that in humans is encoded by the MAP1B gene.^[1][2]

Function

This gene encodes a protein that belongs to the microtubule-associated protein family. The proteins of this family are thought to be involved in microtubule assembly, which is an essential step in neurogenesis. The product of this gene is a precursor polypeptide that presumably undergoes proteolytic processing to generate the final MAP1B heavy chain and LC1 light chain. Gene knockout studies of the mouse microtubule-associated protein 1B gene suggested an important role in development and function of the nervous system. Two alternatively spliced transcript variants have been described.^[2]

Interactions

MAP1B has been shown to interact with Acidic leucine-rich nuclear phosphoprotein 32 family member A^[3] and RASSF1.^[4]

References

1. Lien LL, Boyce FM, Kleyn P, Brzustowicz LM, Menninger J, Ward DC, Gilliam TC, Kunkel LM (Oct 1991). "Mapping of human microtubule-associated protein 1B in proximity to the spinal muscular atrophy locus at 5q13". Proc. Natl. Acad. Sci. U.S.A. 88 (17): 7873–6. doi:10.1073/pnas.88.17.7873. PMC 52406. PMID 1881920.
2. "Entrez Gene: MAP1B microtubule-associated protein 1B".
3. Opal P, Garcia JJ, Propst F, Matilla A, Orr HT, Zoghbi HY (Sep 2003). "Mapmodulin/leucine-rich acidic nuclear protein binds the light chain of microtubule-associated protein 1B and modulates neuritogenesis". J. Biol. Chem. 278 (36): 34691–9. doi:10.1074/jbc.M302785200. PMID 12807913.
4. Dallol A, Agathanggelou A, Fenton SL, Ahmed-Choudhury J, Hesson L, Vos MD, Clark GJ, Downward J, Maher ER, Latif F (Jun 2004). "RASSF1A interacts with microtubule-associated proteins and modulates microtubule dynamics". Cancer Res. 64 (12): 4112–6. doi:10.1158/0008-5472.CAN-04-0267. PMID 15205320.

Further reading

• Hammarback JA, Obar RA, Hughes SM, Vallee RB (1991). "MAP1B is encoded as a polyprotein that is processed to form a complex N-terminal microtubule-binding domain". Neuron 7 (1): 129–39. doi:10.1016/0896-6273(91)90081-A. PMID 1712602.
• Schoenfeld TA, McKerracher L, Obar R, Vallee RB (1989). "MAP 1A and MAP 1B are structurally related microtubule associated proteins with distinct developmental patterns in the CNS". J. Neurosci. 9 (5): 1712–30. PMID 2470876.
• Avila J, Ulloa L, Diez-Guerra J, Diaz-Nido J (1994). "Role of phosphorylated MAPlB in neuritogenesis". Cell Biol. Int. 18 (5): 309–14. doi:10.1006/cbir.1994.1079. PMID 7519512.
• Lien LL, Feener CA, Fischbach N, Kunkel LM (1994). "Cloning of human microtubule-associated protein 1B and the identification of a related gene on chromosome 15". Genomics 22 (2): 273–80. doi:10.1006/geno.1994.1384. PMID 7806212.
• Ohyu J, Takashima S (1998). "Decreased expression of microtubule-associated protein 5 (MAP5) in the molecular layer of cerebellum in preterm infants with olivocerebellar lesions". Brain Dev. 20 (1): 22–6. doi:10.1016/S0387-7604(97)00088-0. PMID 9533556.
• Lucas FR, Goold RG, Gordon-Weeks PR, Salinas PC (1998). "Inhibition of GSK-3beta leading to the loss of phosphorylated MAP-1B is an early event in axonal remodelling induced by WNT-7a or lithium". J. Cell. Sci. 111 ( Pt 10) (10): 1351–61. PMID 9570753.
• Tögel M, Wiche G, Propst F (1998). "Novel features of the light chain of microtubule-associated protein MAP1B: microtubule stabilization, self interaction, actin filament binding, and regulation by the heavy chain". J. Cell Biol. 143 (3): 695–707. doi:10.1083/jcb.143.3.695. PMC 2148156. PMID 9813091.
• Hanley JG, Koulen P, Bedford F, Gordon-Weeks PR, Moss SJ (1999). "The protein MAP-1B links GABA(C) receptors to the cytoskeleton at retinal synapses". Nature 397 (6714): 66–9. doi:10.1038/16258. PMID 9892354.
• Jensen PH, Islam K, Kenney J, Nielsen MS, Power J, Gai WP (2000). "Microtubule-associated protein 1B is a component of cortical Lewy bodies and binds alpha-synuclein filaments". J. Biol. Chem. 275 (28): 21500–7. doi:10.1074/jbc.M000099200. PMID 10764738.
• Tanner SL, Franzen R, Jaffe H, Quarles RH (2000). "Evidence for expression of some microtubule-associated protein 1B in neurons as a plasma membrane glycoprotein". J. Neurochem. 75 (2): 553–62. doi:10.1046/j.1471-4159.2000.0750553.x. PMID 10899930.
• Mei X, Sweatt AJ, Hammarback JA (2000). "Regulation of microtubule-associated protein 1B (MAP1B) subunit composition". J. Neurosci. Res. 62 (1): 56–64. doi:10.1002/1097-4547(20001001)62:1<56::AID-JNR6>3.0.CO;2-#. PMID 11002287.
• Billups D, Hanley JG, Orme M, Attwell D, Moss SJ (2000). "GABAC receptor sensitivity is modulated by interaction with MAP1B". J. Neurosci. 20 (23): 8643–50. PMID 11102469.
• Franzen R, Tanner SL, Dashiell SM, Rottkamp CA, Hammer JA, Quarles RH (2001). "Microtubule-associated protein 1B: a neuronal binding partner for myelin-associated glycoprotein". J. Cell Biol. 155 (6): 893–8. doi:10.1083/jcb.200108137. PMC 2150906. PMID 11733546.
• Ding J, Liu JJ, Kowal AS, Nardine T, Bhattacharya P, Lee A, Yang Y (2002). "Microtubule-associated protein 1B: a neuronal binding partner for gigaxonin". J. Cell Biol. 158 (3): 427–33. doi:10.1083/jcb.200202055. PMC 2173828. PMID 12147674.
• Dergunova LV, Raevskaya NM, Vladychenskaya IP, Limborska SA (2003). "Hmob3 brain-specific sequence is a part of phylogenetically conserved human MAP1B gene 3'-untranslated region". Biomol. Eng. 20 (3): 91–6. doi:10.1016/S1389-0344(03)00003-0. PMID 12684070.
• Chang L, Jones Y, Ellisman MH, Goldstein LS, Karin M (2003). "JNK1 is required for maintenance of neuronal microtubules and controls phosphorylation of microtubule-associated proteins". Dev. Cell 4 (4): 521–33. doi:10.1016/S1534-5807(03)00094-7. PMID 12689591.
• Opal P, Garcia JJ, Propst F, Matilla A, Orr HT, Zoghbi HY (2003). "Mapmodulin/leucine-rich acidic nuclear protein binds the light chain of microtubule-associated protein 1B and modulates neuritogenesis". J. Biol. Chem. 278 (36): 34691–9. doi:10.1074/jbc.M302785200. PMID 12807913.