MED30

Mediator complex subunit 30
Identifiers
Symbols	MED30 ; MED30S; THRAP6; TRAP25
External IDs	OMIM: 610237 MGI: 1917040 HomoloGene: 12329 GeneCards: MED30 Gene
Gene ontology Molecular function • RNA polymerase II transcription cofactor activity • transcription cofactor activity • receptor activity • protein binding • ligand-dependent nuclear receptor transcription coactivator activity • vitamin D receptor binding • thyroid hormone receptor binding Cellular component • nucleus • nucleoplasm • mediator complex Biological process • regulation of transcription from RNA polymerase II promoter • transcription initiation from RNA polymerase II promoter • gene expression • stem cell maintenance • intracellular steroid hormone receptor signaling pathway • androgen receptor signaling pathway • positive regulation of transcription, DNA-templated Sources: Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	90390	69790
Ensembl	ENSG00000164758	ENSMUSG00000038622
UniProt	Q96HR3	Q9CQI9
RefSeq (mRNA)	NM_001282986	NM_027212
RefSeq (protein)	NP_001269915	NP_081488
Location (UCSC)	Chr 8: 117.52 – 117.54 Mb	Chr 15: 52.71 – 52.73 Mb
PubMed search

Med30
Identifiers
Symbol	Med30
Pfam	PF11315
InterPro	IPR021019
Available protein structures: Pfam structures PDB RCSB PDB; PDBe; PDBj PDBsum structure summary

Mediator of RNA polymerase II transcription subunit 30 is an enzyme that in humans is encoded by the MED30 gene.^[1] It represents subunit Med30 of the Mediator complex and is metazoan-specific,^[2] having no homologues in yeasts.

Interactions

MED30 has been shown to interact with MED22.^[3]

References

1. "Entrez Gene: THRAP6 thyroid hormone receptor associated protein 6".
2. Baek HJ, Malik S, Qin J, Roeder RG (Apr 2002). "Requirement of TRAP/mediator for both activator-independent and activator-dependent transcription in conjunction with TFIID-associated TAF(II)s". Molecular and Cellular Biology 22 (8): 2842–52. doi:10.1128/MCB.22.8.2842-2852.2002. PMC 133729. PMID 11909976.
3. Sato S, Tomomori-Sato C, Banks CA, Sorokina I, Parmely TJ, Kong SE, Jin J, Cai Y, Lane WS, Brower CS, Conaway RC, Conaway JW (Apr 2003). "Identification of mammalian Mediator subunits with similarities to yeast Mediator subunits Srb5, Srb6, Med11, and Rox3". The Journal of Biological Chemistry 278 (17): 15123–7. doi:10.1074/jbc.C300054200. PMID 12584197.

Further reading

• Sato S, Tomomori-Sato C, Parmely TJ, Florens L, Zybailov B, Swanson SK, Banks CA, Jin J, Cai Y, Washburn MP, Conaway JW, Conaway RC (Jun 2004). "A set of consensus mammalian mediator subunits identified by multidimensional protein identification technology". Molecular Cell 14 (5): 685–91. doi:10.1016/j.molcel.2004.05.006. PMID 15175163.
• Tomomori-Sato C, Sato S, Parmely TJ, Banks CA, Sorokina I, Florens L, Zybailov B, Washburn MP, Brower CS, Conaway RC, Conaway JW (Feb 2004). "A mammalian mediator subunit that shares properties with Saccharomyces cerevisiae mediator subunit Cse2". The Journal of Biological Chemistry 279 (7): 5846–51. doi:10.1074/jbc.M312523200. PMID 14638676.
• Sato S, Tomomori-Sato C, Banks CA, Parmely TJ, Sorokina I, Brower CS, Conaway RC, Conaway JW (Dec 2003). "A mammalian homolog of Drosophila melanogaster transcriptional coactivator intersex is a subunit of the mammalian Mediator complex". The Journal of Biological Chemistry 278 (50): 49671–4. doi:10.1074/jbc.C300444200. PMID 14576168.
• Sato S, Tomomori-Sato C, Banks CA, Sorokina I, Parmely TJ, Kong SE, Jin J, Cai Y, Lane WS, Brower CS, Conaway RC, Conaway JW (Apr 2003). "Identification of mammalian Mediator subunits with similarities to yeast Mediator subunits Srb5, Srb6, Med11, and Rox3". The Journal of Biological Chemistry 278 (17): 15123–7. doi:10.1074/jbc.C300054200. PMID 12584197.
• Wang Q, Sharma D, Ren Y, Fondell JD (Nov 2002). "A coregulatory role for the TRAP-mediator complex in androgen receptor-mediated gene expression". The Journal of Biological Chemistry 277 (45): 42852–8. doi:10.1074/jbc.M206061200. PMID 12218053.
• Kutsenko AS, Gizatullin RZ, Al-Amin AN, Wang F, Kvasha SM, Podowski RM, Matushkin YG, Gyanchandani A, Muravenko OV, Levitsky VG, Kolchanov NA, Protopopov AI, Kashuba VI, Kisselev LL, Wasserman W, Wahlestedt C, Zabarovsky ER (Jul 2002). "NotI flanking sequences: a tool for gene discovery and verification of the human genome". Nucleic Acids Research 30 (14): 3163–70. doi:10.1093/nar/gkf428. PMC 135748. PMID 12136098.
• Baek HJ, Malik S, Qin J, Roeder RG (Apr 2002). "Requirement of TRAP/mediator for both activator-independent and activator-dependent transcription in conjunction with TFIID-associated TAF(II)s". Molecular and Cellular Biology 22 (8): 2842–52. doi:10.1128/MCB.22.8.2842-2852.2002. PMC 133729. PMID 11909976.
• Suzuki H, Fukunishi Y, Kagawa I, Saito R, Oda H, Endo T, Kondo S, Bono H, Okazaki Y, Hayashizaki Y (Oct 2001). "Protein-protein interaction panel using mouse full-length cDNAs". Genome Research 11 (10): 1758–65. doi:10.1101/gr.180101. PMC 311163. PMID 11591653.
• Näär AM, Beaurang PA, Zhou S, Abraham S, Solomon W, Tjian R (Apr 1999). "Composite co-activator ARC mediates chromatin-directed transcriptional activation". Nature 398 (6730): 828–32. doi:10.1038/19789. PMID 10235267.
• Rachez C, Lemon BD, Suldan Z, Bromleigh V, Gamble M, Näär AM, Erdjument-Bromage H, Tempst P, Freedman LP (Apr 1999). "Ligand-dependent transcription activation by nuclear receptors requires the DRIP complex". Nature 398 (6730): 824–8. doi:10.1038/19783. PMID 10235266.
• Ito M, Yuan CX, Malik S, Gu W, Fondell JD, Yamamura S, Fu ZY, Zhang X, Qin J, Roeder RG (Mar 1999). "Identity between TRAP and SMCC complexes indicates novel pathways for the function of nuclear receptors and diverse mammalian activators". Molecular Cell 3 (3): 361–70. doi:10.1016/S1097-2765(00)80463-3. PMID 10198638.

This article incorporates text from the public domain Pfam and InterPro IPR021019