MIB1 (gene)

MIB1 marker also used for detection of grades of astrocytoma

Mindbomb E3 ubiquitin protein ligase 1
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 4TSE​, 4XI6​, 4XI7​, 4XIB​
Identifiers
Symbols	MIB1 ; DIP-1; DIP1; LVNC7; MIB; ZZANK2; ZZZ6
External IDs	OMIM: 608677 MGI: 2443157 HomoloGene: 10810 GeneCards: MIB1 Gene
Gene ontology Molecular function • ubiquitin-protein transferase activity • protein binding • zinc ion binding • ligase activity Cellular component • cytoplasm • centrosome • cytosol • plasma membrane • postsynaptic density • cytoplasmic vesicle Biological process • blood vessel development • in utero embryonic development • somitogenesis • neural tube formation • heart looping • endocytosis • Notch signaling pathway • protein ubiquitination • negative regulation of neuron differentiation • positive regulation of endocytosis Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	57534	225164
Ensembl	ENSG00000101752	ENSMUSG00000024294
UniProt	Q86YT6	Q80SY4
RefSeq (mRNA)	NM_020774	NM_144860
RefSeq (protein)	NP_065825	NP_659109
Location (UCSC)	Chr 18: 21.7 – 21.87 Mb	Chr 18: 10.73 – 10.82 Mb
PubMed search

E3 ubiquitin-protein ligase MIB1 is an enzyme that in humans is encoded by the MIB1 gene.^[1] It is involved in regulating apoptosis.^[2]

Confusion with proliferative marker

An antibody directed at the protein Ki-67, a product of the MKI67 gene, is called MIB-1.^[3] The MIB1 gene, which regulates apoptosis, should not be confused with the MIB-1 antibody, which is used to measure Ki-67 expression.

References

1. "Entrez Gene: MIB1 mindbomb homolog 1 (Drosophila)".
2. MIB1. OMIM.URL: http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=608677. Accessed on: April 24, 2009.
3. MIB-1. Veripath OncoDiagnostics. http://www.oncodx.org/onco/mib_1.htm. Accessed on: April 24, 2009.

Further reading

• Nagase T, Kikuno R, Ishikawa KI, et al. (2000). "Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro.". DNA Res. 7 (1): 65–73. doi:10.1093/dnares/7.1.65. PMID 10718198.
• Wang Z, Tseng CP, Pong RC, et al. (2002). "The mechanism of growth-inhibitory effect of DOC-2/DAB2 in prostate cancer. Characterization of a novel GTPase-activating protein associated with N-terminal domain of DOC-2/DAB2.". J. Biol. Chem. 277 (15): 12622–31. doi:10.1074/jbc.M110568200. PMID 11812785.
• Jin Y, Blue EK, Dixon S, et al. (2003). "A death-associated protein kinase (DAPK)-interacting protein, DIP-1, is an E3 ubiquitin ligase that promotes tumor necrosis factor-induced apoptosis and regulates the cellular levels of DAPK.". J. Biol. Chem. 277 (49): 46980–6. doi:10.1074/jbc.M208585200. PMC 2824503. PMID 12351649.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Itoh M, Kim CH, Palardy G, et al. (2003). "Mind bomb is a ubiquitin ligase that is essential for efficient activation of Notch signaling by Delta.". Dev. Cell 4 (1): 67–82. doi:10.1016/S1534-5807(02)00409-4. PMID 12530964.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Henshall DC, Schindler CK, So NK, et al. (2004). "Death-associated protein kinase expression in human temporal lobe epilepsy.". Ann. Neurol. 55 (4): 485–94. doi:10.1002/ana.20001. PMID 15048887.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Yoo KW, Kim EH, Jung SH, et al. (2006). "Snx5, as a Mind bomb-binding protein, is expressed in hematopoietic and endothelial precursor cells in zebrafish.". FEBS Lett. 580 (18): 4409–16. doi:10.1016/j.febslet.2006.07.009. PMID 16857196.
• Song R, Koo BK, Yoon KJ, et al. (2007). "Neuralized-2 regulates a Notch ligand in cooperation with Mind bomb-1.". J. Biol. Chem. 281 (47): 36391–400. doi:10.1074/jbc.M606601200. PMID 17003037.
• Zhang L, Nephew KP, Gallagher PJ (2007). "Regulation of death-associated protein kinase. Stabilization by HSP90 heterocomplexes.". J. Biol. Chem. 282 (16): 11795–804. doi:10.1074/jbc.M610430200. PMC 2823631. PMID 17324930.
• Yakut T, Gutenberg A, Bekar A, et al. (2007). "Correlation of chromosomal imbalances by comparative genomic hybridization and expression of EGFR, PTEN, p53, and MIB-1 in diffuse gliomas.". Oncol. Rep. 17 (5): 1037–43. doi:10.3892/or.17.5.1037. PMID 17390041.
• van der Avoort IA, van der Laak JA, Paffen A, et al. (2007). "MIB1 expression in basal cell layer: a diagnostic tool to identify premalignancies of the vulva.". Mod. Pathol. 20 (7): 770–8. doi:10.1038/modpathol.3800796. PMID 17464313.