MLLT10

Myeloid/lymphoid or mixed-lineage leukemia; translocated to, 10
Identifiers
Symbols	MLLT10 ; AF10
External IDs	OMIM: 602409 MGI: 1329038 HomoloGene: 20973 GeneCards: MLLT10 Gene
Gene ontology Molecular function • DNA binding • transcription factor activity, sequence-specific DNA binding • protein binding • zinc ion binding Cellular component • nucleoplasm • cytoplasm Biological process • transcription, DNA-templated • positive regulation of transcription from RNA polymerase II promoter Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	8028	17354
Ensembl	ENSG00000078403	ENSMUSG00000026743
UniProt	P55197	O54826
RefSeq (mRNA)	NM_001009569	NM_001252560
RefSeq (protein)	NP_001182555	NP_001239489
Location (UCSC)	Chr 10: 21.52 – 21.74 Mb	Chr 2: 18.06 – 18.21 Mb
PubMed search

Protein AF-10 is a protein that in humans is encoded by the MLLT10 gene.^[1][2]

Interactions

MLLT10 has been shown to interact with SS18.^[3]

References

1. Chaplin T, Ayton P, Bernard OA, Saha V, Della Valle V, Hillion J, Gregorini A, Lillington D, Berger R, Young BD (Apr 1995). "A novel class of zinc finger/leucine zipper genes identified from the molecular cloning of the t(10;11) translocation in acute leukemia". Blood 85 (6): 1435–41. PMID 7888665.
2. "Entrez Gene: MLLT10 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10".
3. de Bruijn DR, dos Santos NR, Thijssen J, Balemans M, Debernardi S, Linder B, Young BD, Geurts van Kessel A (May 2001). "The synovial sarcoma associated protein SYT interacts with the acute leukemia associated protein AF10". Oncogene 20 (25): 3281–9. doi:10.1038/sj.onc.1204419. PMID 11423977.

Further reading

• Silliman CC, McGavran L, Wei Q, Miller LA, Li S, Hunger SP (1998). "Alternative splicing in wild-type AF10 and CALM cDNAs and in AF10-CALM and CALM-AF10 fusion cDNAs produced by the t(10;11)(p13-14;q14-q21) suggests a potential role for truncated AF10 polypeptides". Leukemia 12 (9): 1404–10. doi:10.1038/sj.leu.2401109. PMID 9737689.
• Linder B, Newman R, Jones LK, Debernardi S, Young BD, Freemont P, Verrijzer CP, Saha V (2000). "Biochemical analyses of the AF10 protein: the extended LAP/PHD-finger mediates oligomerisation". J. Mol. Biol. 299 (2): 369–78. doi:10.1006/jmbi.2000.3766. PMID 10860745.
• Lillington DM, Jaju RJ, Shankar AG, Neat M, Kearney L, Young BD, Saha V (2000). "Cytogenetic and molecular evidence of marrow involvement in extramedullary acute myeloid leukaemia". Br. J. Haematol. 110 (3): 547–51. doi:10.1046/j.1365-2141.2000.02212.x. PMID 10997963.
• de Bruijn DR, dos Santos NR, Thijssen J, Balemans M, Debernardi S, Linder B, Young BD, Geurts van Kessel A (2001). "The synovial sarcoma associated protein SYT interacts with the acute leukemia associated protein AF10". Oncogene 20 (25): 3281–9. doi:10.1038/sj.onc.1204419. PMID 11423977.
• Debernardi S, Bassini A, Jones LK, Chaplin T, Linder B, de Bruijn DR, Meese E, Young BD (2002). "The MLL fusion partner AF10 binds GAS41, a protein that interacts with the human SWI/SNF complex". Blood 99 (1): 275–81. doi:10.1182/blood.V99.1.275. PMID 11756182.
• Cai Y, Gao Y, Sheng Q, Miao S, Cui X, Wang L, Zong S, Koide SS (2002). "Characterization and potential function of a novel testis-specific nucleoporin BS-63". Mol. Reprod. Dev. 61 (1): 126–34. doi:10.1002/mrd.1139. PMID 11774384.
• Roll P, Zattara-Cannoni H, Bustos-Bernard MC, Curtillet C, Michel G, Vagner-Capodano AM (2002). "Molecular and fluorescence in situ hybridization analysis of a 10;11 rearrangement in a case of infant acute monocytic leukemia". Cancer Genet. Cytogenet. 135 (2): 187–91. doi:10.1016/S0165-4608(01)00644-6. PMID 12127405.
• Nakamura T, Mori T, Tada S, Krajewski W, Rozovskaia T, Wassell R, Dubois G, Mazo A, Croce CM, Canaani E (2002). "ALL-1 is a histone methyltransferase that assembles a supercomplex of proteins involved in transcriptional regulation". Mol. Cell 10 (5): 1119–28. doi:10.1016/S1097-2765(02)00740-2. PMID 12453419.
• Perrin L, Bloyer S, Ferraz C, Agrawal N, Sinha P, Dura JM (2003). "The leucine zipper motif of the Drosophila AF10 homologue can inhibit PRE-mediated repression: implications for leukemogenic activity of human MLL-AF10 fusions". Mol. Cell. Biol. 23 (1): 119–30. doi:10.1128/MCB.23.1.119-130.2003. PMC 140655. PMID 12482966.
• Okada Y, Feng Q, Lin Y, Jiang Q, Li Y, Coffield VM, Su L, Xu G, Zhang Y (2005). "hDOT1L links histone methylation to leukemogenesis". Cell 121 (2): 167–78. doi:10.1016/j.cell.2005.02.020. PMID 15851025.