SS18

Synovial sarcoma translocation, chromosome 18
Identifiers
Symbols SS18 ; SSXT; SYT
External IDs OMIM: 600192 MGI: 107708 HomoloGene: 38080 GeneCards: SS18 Gene
RNA expression pattern
More reference expression data
Orthologs
Species Human Mouse
Entrez 6760 268996
Ensembl ENSG00000141380 ENSMUSG00000037013
UniProt Q15532 Q62280
RefSeq (mRNA) NM_001007559 NM_001161369
RefSeq (protein) NP_001007560 NP_001154841
Location (UCSC) Chr 18:
26.02 – 26.09 Mb		 Chr 18:
14.62 – 14.68 Mb
PubMed search

Protein SSXT is a protein that in humans is encoded by the SS18 gene.[1][2][3]

Function

SS18 is a member of the human SWI/SNF chromatin remodeling complex.[4][5][6]

Clinical significance

SS18 is involved in a chromosomal translocation commonly found in synovial sarcoma.[7]

Interactions

SS18 has been shown to interact with:

References

  1. ↑ Shipley JM, Clark J, Crew AJ, Birdsall S, Rocques PJ, Gill S, Chelly J, Monaco AP, Abe S, Gusterson BA (May 1994). "The t(X;18)(p11.2;q11.2) translocation found in human synovial sarcomas involves two distinct loci on the X chromosome". Oncogene 9 (5): 1447–53. PMID 8152806.
  2. ↑ Clark J, Rocques PJ, Crew AJ, Gill S, Shipley J, Chan AM, Gusterson BA, Cooper CS (Aug 1994). "Identification of novel genes, SYT and SSX, involved in the t(X;18)(p11.2;q11.2) translocation found in human synovial sarcoma". Nature Genetics 7 (4): 502–8. doi:10.1038/ng0894-502. PMID 7951320.
  3. ↑ de Bruijn DR, Geurts van Kessel A (2006). "Common origin of the human synovial sarcoma associated SS18 and SS18L1 gene loci". Cytogenetic and Genome Research 112 (3-4): 222–6. doi:10.1159/000089874. PMID 16484776.
  4. ↑ Middeljans E, Wan X, Jansen PW, Sharma V, Stunnenberg HG, Logie C (2012). "SS18 together with animal-specific factors defines human BAF-type SWI/SNF complexes". PLOS ONE 7 (3): e33834. doi:10.1371/journal.pone.0033834. PMC 3307773. PMID 22442726.
  5. 1 2 Kato H, Tjernberg A, Zhang W, Krutchinsky AN, An W, Takeuchi T, Ohtsuki Y, Sugano S, de Bruijn DR, Chait BT, Roeder RG (Feb 2002). "SYT associates with human SNF/SWI complexes and the C-terminal region of its fusion partner SSX1 targets histones". The Journal of Biological Chemistry 277 (7): 5498–505. doi:10.1074/jbc.M108702200. PMID 11734557.
  6. 1 2 Perani M, Ingram CJ, Cooper CS, Garrett MD, Goodwin GH (Nov 2003). "Conserved SNH domain of the proto-oncoprotein SYT interacts with components of the human chromatin remodelling complexes, while the QPGY repeat domain forms homo-oligomers". Oncogene 22 (50): 8156–67. doi:10.1038/sj.onc.1207031. PMID 14603256.
  7. ↑ Yang K, Lui WO, Xie Y, Zhang A, Skytting B, Mandahl N, Larsson C, Larsson O (Jun 2002). "Co-existence of SYT-SSX1 and SYT-SSX2 fusions in synovial sarcomas". Oncogene 21 (26): 4181–90. doi:10.1038/sj.onc.1205569. PMID 12037676.
  8. ↑ Eid JE, Kung AL, Scully R, Livingston DM (Sep 2000). "p300 interacts with the nuclear proto-oncoprotein SYT as part of the active control of cell adhesion". Cell 102 (6): 839–48. doi:10.1016/S0092-8674(00)00072-6. PMID 11030627.
  9. ↑ de Bruijn DR, dos Santos NR, Thijssen J, Balemans M, Debernardi S, Linder B, Young BD, Geurts van Kessel A (May 2001). "The synovial sarcoma associated protein SYT interacts with the acute leukemia associated protein AF10". Oncogene 20 (25): 3281–9. doi:10.1038/sj.onc.1204419. PMID 11423977.

Further reading

  • Fligman I, Lonardo F, Jhanwar SC, Gerald WL, Woodruff J, Ladanyi M (Dec 1995). "Molecular diagnosis of synovial sarcoma and characterization of a variant SYT-SSX2 fusion transcript". The American Journal of Pathology 147 (6): 1592–9. PMC 1869933. PMID 7495284. 
  • Brett D, Whitehouse S, Antonson P, Shipley J, Cooper C, Goodwin G (Sep 1997). "The SYT protein involved in the t(X;18) synovial sarcoma translocation is a transcriptional activator localised in nuclear bodies". Human Molecular Genetics 6 (9): 1559–64. doi:10.1093/hmg/6.9.1559. PMID 9285794. 
  • Thaete C, Brett D, Monaghan P, Whitehouse S, Rennie G, Rayner E, Cooper CS, Goodwin G (Apr 1999). "Functional domains of the SYT and SYT-SSX synovial sarcoma translocation proteins and co-localization with the SNF protein BRM in the nucleus". Human Molecular Genetics 8 (4): 585–91. doi:10.1093/hmg/8.4.585. PMID 10072425. 
  • Eid JE, Kung AL, Scully R, Livingston DM (Sep 2000). "p300 interacts with the nuclear proto-oncoprotein SYT as part of the active control of cell adhesion". Cell 102 (6): 839–48. doi:10.1016/S0092-8674(00)00072-6. PMID 11030627. 
  • Tamborini E, Agus V, Mezzelani A, Riva C, Sozzi G, Azzarelli A, Pierotti MA, Pilotti S (Apr 2001). "Identification of a novel spliced variant of the SYT gene expressed in normal tissues and in synovial sarcoma". British Journal of Cancer 84 (8): 1087–94. doi:10.1054/bjoc.2000.1710. PMC 2363857. PMID 11308259. 
  • Brodin B, Haslam K, Yang K, Bartolazzi A, Xie Y, Starborg M, Lundeberg J, Larsson O (May 2001). "Cloning and characterization of spliced fusion transcript variants of synovial sarcoma: SYT/SSX4, SYT/SSX4v, and SYT/SSX2v. Possible regulatory role of the fusion gene product in wild type SYT expression". Gene 268 (1-2): 173–82. doi:10.1016/S0378-1119(01)00412-7. PMID 11368913. 
  • de Bruijn DR, dos Santos NR, Thijssen J, Balemans M, Debernardi S, Linder B, Young BD, Geurts van Kessel A (May 2001). "The synovial sarcoma associated protein SYT interacts with the acute leukemia associated protein AF10". Oncogene 20 (25): 3281–9. doi:10.1038/sj.onc.1204419. PMID 11423977. 
  • Suzuki H, Fukunishi Y, Kagawa I, Saito R, Oda H, Endo T, Kondo S, Bono H, Okazaki Y, Hayashizaki Y (Oct 2001). "Protein-protein interaction panel using mouse full-length cDNAs". Genome Research 11 (10): 1758–65. doi:10.1101/gr.180101. PMC 311163. PMID 11591653. 
  • Kato H, Tjernberg A, Zhang W, Krutchinsky AN, An W, Takeuchi T, Ohtsuki Y, Sugano S, de Bruijn DR, Chait BT, Roeder RG (Feb 2002). "SYT associates with human SNF/SWI complexes and the C-terminal region of its fusion partner SSX1 targets histones". The Journal of Biological Chemistry 277 (7): 5498–505. doi:10.1074/jbc.M108702200. PMID 11734557. 
  • Yang K, Lui WO, Xie Y, Zhang A, Skytting B, Mandahl N, Larsson C, Larsson O (Jun 2002). "Co-existence of SYT-SSX1 and SYT-SSX2 fusions in synovial sarcomas". Oncogene 21 (26): 4181–90. doi:10.1038/sj.onc.1205569. PMID 12037676. 
  • Imabayashi H, Mori T, Gojo S, Kiyono T, Sugiyama T, Irie R, Isogai T, Hata J, Toyama Y, Umezawa A (Aug 2003). "Redifferentiation of dedifferentiated chondrocytes and chondrogenesis of human bone marrow stromal cells via chondrosphere formation with expression profiling by large-scale cDNA analysis". Experimental Cell Research 288 (1): 35–50. doi:10.1016/S0014-4827(03)00130-7. PMID 12878157. 
  • Perani M, Ingram CJ, Cooper CS, Garrett MD, Goodwin GH (Nov 2003). "Conserved SNH domain of the proto-oncoprotein SYT interacts with components of the human chromatin remodelling complexes, while the QPGY repeat domain forms homo-oligomers". Oncogene 22 (50): 8156–67. doi:10.1038/sj.onc.1207031. PMID 14603256. 
  • Iwasaki T, Koibuchi N, Chin WW (Sep 2005). "Synovial sarcoma translocation (SYT) encodes a nuclear receptor coactivator". Endocrinology 146 (9): 3892–9. doi:10.1210/en.2004-1513. PMID 15919756. 
  • Fernebro J, Francis P, Edén P, Borg A, Panagopoulos I, Mertens F, Vallon-Christersson J, Akerman M, Rydholm A, Bauer HC, Mandahl N, Nilbert M (Mar 2006). "Gene expression profiles relate to SS18/SSX fusion type in synovial sarcoma". International Journal of Cancer. Journal International Du Cancer 118 (5): 1165–72. doi:10.1002/ijc.21475. PMID 16152617. 
  • Perani M, Antonson P, Hamoudi R, Ingram CJ, Cooper CS, Garrett MD, Goodwin GH (Dec 2005). "The proto-oncoprotein SYT interacts with SYT-interacting protein/co-activator activator (SIP/CoAA), a human nuclear receptor co-activator with similarity to EWS and TLS/FUS family of proteins". The Journal of Biological Chemistry 280 (52): 42863–76. doi:10.1074/jbc.M502963200. PMID 16227627. 
  • Sun Y, Gao D, Liu Y, Huang J, Lessnick S, Tanaka S (Feb 2006). "IGF2 is critical for tumorigenesis by synovial sarcoma oncoprotein SYT-SSX1". Oncogene 25 (7): 1042–52. doi:10.1038/sj.onc.1209143. PMID 16247461. 
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