MZF1

Myeloid zinc finger 1
PDB rendering based on 2fi2.
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 2FI2​
Identifiers
Symbols	MZF1 ; MZF-1; MZF1B; ZFP98; ZNF42; ZSCAN6
External IDs	OMIM: 194550 MGI: 107457 HomoloGene: 9633 GeneCards: MZF1 Gene
Gene ontology Molecular function • RNA polymerase II core promoter proximal region sequence-specific DNA binding • transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding • transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding • transcription factor activity, sequence-specific DNA binding • protein binding • protein homodimerization activity • transcription regulatory region DNA binding • metal ion binding Cellular component • nucleus Biological process • negative regulation of transcription from RNA polymerase II promoter • regulation of transcription, DNA-templated • transcription from RNA polymerase II promoter • positive regulation of transcription from RNA polymerase II promoter Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	7593	109889
Ensembl	ENSG00000099326	ENSMUSG00000030380
UniProt	P28698	A1L357
RefSeq (mRNA)	NM_001267033	NM_001290452
RefSeq (protein)	NP_001253962	NP_001277381
Location (UCSC)	Chr 19: 58.56 – 58.57 Mb	Chr 7: 13.04 – 13.05 Mb
PubMed search

Myeloid zinc finger 1 is a protein that in humans is encoded by the MZF1 gene.^[1][2]

Interactions

MZF1 has been shown to interact with SCAND1.^[3] MZF-1 has been shown to induce the GAPDH gene, something that must be considered when GAPDH is used as a loading control in experiments that may induce or perturb MZF-1.^[4]

References

1. Hromas R, Collins SJ, Hickstein D, Raskind W, Deaven LL, O'Hara P, Hagen FS, Kaushansky K (September 1991). "A retinoic acid-responsive human zinc finger gene, MZF-1, preferentially expressed in myeloid cells". J Biol Chem 266 (22): 14183–7. PMID 1860835.
2. "Entrez Gene: MZF1 myeloid zinc finger 1".
3. Sander TL, Haas AL, Peterson MJ, Morris JF (April 2000). "Identification of a novel SCAN box-related protein that interacts with MZF1B. The leucine-rich SCAN box mediates hetero- and homoprotein associations". J. Biol. Chem. 275 (17): 12857–12867. doi:10.1074/jbc.275.17.12857. PMID 10777584.
4. Piszczatowski RT, Rafferty BJ, Rozado A, Tobak S, Lents NH (2014). "The glyceraldehyde 3-phosphate dehydrogenase gene (GAPDH) is regulated by myeloid zinc finger 1 (MZF-1) and is induced by calcitriol". Biochem. Biophys. Res. Commun. 451 (1): 137–41. doi:10.1016/j.bbrc.2014.07.082. PMID 25065746.

Further reading

• Bavisotto L, Kaushansky K, Lin N, Hromas R (1991). "Antisense oligonucleotides from the stage-specific myeloid zinc finger gene MZF-1 inhibit granulopoiesis in vitro". J. Exp. Med. 174 (5): 1097–1101. doi:10.1084/jem.174.5.1097. PMC 2119006. PMID 1719120.
• Sander TL, Haas AL, Peterson MJ, Morris JF (2000). "Identification of a novel SCAN box-related protein that interacts with MZF1B. The leucine-rich SCAN box mediates hetero- and homoprotein associations". J. Biol. Chem. 275 (17): 12857–12867. doi:10.1074/jbc.275.17.12857. PMID 10777584.
• Peterson MJ, Morris JF (2000). "Human myeloid zinc finger gene MZF produces multiple transcripts and encodes a SCAN box protein". Gene 254 (1–2): 105–118. doi:10.1016/S0378-1119(00)00281-X. PMID 10974541.
• Takahashi K, Matsumoto C, Ra C (2005). "FHL3 negatively regulates human high-affinity IgE receptor beta-chain gene expression by acting as a transcriptional co-repressor of MZF-1". Biochem. J. 386 (Pt 1): 191–200. doi:10.1042/BJ20040775. PMC 1134781. PMID 15453830.
• Kang NY, Park YD, Choi HJ, Kim KS, Lee YC, Kim CH (2005). "Regulatory elements involved in transcription of the human NeuAcalpha2,3Galbeta1,3GalNAcalpha2,6-sialyltransferase (hST6GalNAc IV) gene". Mol. Cells 18 (2): 157–62. PMID 15528990.
• Le Mée S, Fromigué O, Marie PJ (2005). "Sp1/Sp3 and the myeloid zinc finger gene MZF1 regulate the human N-cadherin promoter in osteoblasts". Exp. Cell Res. 302 (1): 129–142. doi:10.1016/j.yexcr.2004.08.028. PMID 15541732.
• Inoue M, Takahashi K, Niide O, Shibata M, Fukuzawa M, Ra C (2005). "LDOC1, a novel MZF-1-interacting protein, induces apoptosis". FEBS Lett. 579 (3): 604–608. doi:10.1016/j.febslet.2004.12.030. PMID 15670815.
• Hsieh YH, Wu TT, Tsai JH, Huang CY, Hsieh YS, Liu JY (2006). "PKCalpha expression regulated by Elk-1 and MZF-1 in human HCC cells". Biochem. Biophys. Res. Commun. 339 (1): 217–225. doi:10.1016/j.bbrc.2005.11.015. PMID 16297876.
• Peterson FC, Hayes PL, Waltner JK, Heisner AK, Jensen DR, Sander TL, Volkman BF (2006). "Structure of the SCAN domain from the tumor suppressor protein MZF1". J. Mol. Biol. 363 (1): 137–147. doi:10.1016/j.jmb.2006.07.063. PMC 1941711. PMID 16950398.
• Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell 127 (3): 635–648. doi:10.1016/j.cell.2006.09.026. PMID 17081983.