SCAND1

SCAN domain containing 1
Identifiers
Symbols SCAND1 ; RAZ1; SDP1
External IDs OMIM: 610416 MGI: 1343132 HomoloGene: 10642 GeneCards: SCAND1 Gene
RNA expression pattern
More reference expression data
Orthologs
Species Human Mouse
Entrez 51282 19018
Ensembl ENSG00000171222 ENSMUSG00000046229
UniProt P57086 E9PVP7
RefSeq (mRNA) NM_016558 NM_020255
RefSeq (protein) NP_057642 NP_064651
Location (UCSC) Chr 20:
35.95 – 35.96 Mb
Chr 2:
156.31 – 156.31 Mb
PubMed search

SCAN domain-containing protein 1 is a protein that in humans is encoded by the SCAND1 gene.[1][2][3][4]

Function

The SCAN domain is a highly conserved, leucine-rich motif of approximately 60 aa originally found within a subfamily of zinc finger proteins. This gene belongs to a family of genes that encode an isolated SCAN domain, but no zinc finger motif. Functional studies have established that the SCAN box is a protein interaction domain that mediates both hetero- and homoprotein associations, and maybe involved in regulation of transcriptional activity. Two transcript variants with different 5' UTRs, but encoding the same protein, have been described for this gene.[4]

Interactions

SCAND1 has been shown to interact with MZF1.[1]

References

  1. 1 2 Sander TL, Haas AL, Peterson MJ, Morris JF (Apr 2000). "Identification of a novel SCAN box-related protein that interacts with MZF1B. The leucine-rich SCAN box mediates hetero- and homoprotein associations". The Journal of Biological Chemistry 275 (17): 12857–67. doi:10.1074/jbc.275.17.12857. PMID 10777584.
  2. Schumacher C, Wang H, Honer C, Ding W, Koehn J, Lawrence Q, Coulis CM, Wang LL, Ballinger D, Bowen BR, Wagner S (Jun 2000). "The SCAN domain mediates selective oligomerization". The Journal of Biological Chemistry 275 (22): 17173–9. doi:10.1074/jbc.M000119200. PMID 10747874.
  3. Babb R, Bowen BR (Mar 2003). "SDP1 is a peroxisome-proliferator-activated receptor gamma 2 co-activator that binds through its SCAN domain". The Biochemical Journal 370 (Pt 2): 719–27. doi:10.1042/BJ20021378. PMC 1223195. PMID 12444922.
  4. 1 2 "Entrez Gene: SCAND1 SCAN domain containing 1".

Further reading


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