SCAND1
SCAN domain containing 1 | |||||||||||||
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Identifiers | |||||||||||||
Symbols | SCAND1 ; RAZ1; SDP1 | ||||||||||||
External IDs | OMIM: 610416 MGI: 1343132 HomoloGene: 10642 GeneCards: SCAND1 Gene | ||||||||||||
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RNA expression pattern | |||||||||||||
More reference expression data | |||||||||||||
Orthologs | |||||||||||||
Species | Human | Mouse | |||||||||||
Entrez | 51282 | 19018 | |||||||||||
Ensembl | ENSG00000171222 | ENSMUSG00000046229 | |||||||||||
UniProt | P57086 | E9PVP7 | |||||||||||
RefSeq (mRNA) | NM_016558 | NM_020255 | |||||||||||
RefSeq (protein) | NP_057642 | NP_064651 | |||||||||||
Location (UCSC) |
Chr 20: 35.95 – 35.96 Mb |
Chr 2: 156.31 – 156.31 Mb | |||||||||||
PubMed search | |||||||||||||
SCAN domain-containing protein 1 is a protein that in humans is encoded by the SCAND1 gene.[1][2][3][4]
Function
The SCAN domain is a highly conserved, leucine-rich motif of approximately 60 aa originally found within a subfamily of zinc finger proteins. This gene belongs to a family of genes that encode an isolated SCAN domain, but no zinc finger motif. Functional studies have established that the SCAN box is a protein interaction domain that mediates both hetero- and homoprotein associations, and maybe involved in regulation of transcriptional activity. Two transcript variants with different 5' UTRs, but encoding the same protein, have been described for this gene.[4]
Interactions
SCAND1 has been shown to interact with MZF1.[1]
References
- 1 2 Sander TL, Haas AL, Peterson MJ, Morris JF (Apr 2000). "Identification of a novel SCAN box-related protein that interacts with MZF1B. The leucine-rich SCAN box mediates hetero- and homoprotein associations". The Journal of Biological Chemistry 275 (17): 12857–67. doi:10.1074/jbc.275.17.12857. PMID 10777584.
- ↑ Schumacher C, Wang H, Honer C, Ding W, Koehn J, Lawrence Q, Coulis CM, Wang LL, Ballinger D, Bowen BR, Wagner S (Jun 2000). "The SCAN domain mediates selective oligomerization". The Journal of Biological Chemistry 275 (22): 17173–9. doi:10.1074/jbc.M000119200. PMID 10747874.
- ↑ Babb R, Bowen BR (Mar 2003). "SDP1 is a peroxisome-proliferator-activated receptor gamma 2 co-activator that binds through its SCAN domain". The Biochemical Journal 370 (Pt 2): 719–27. doi:10.1042/BJ20021378. PMC 1223195. PMID 12444922.
- 1 2 "Entrez Gene: SCAND1 SCAN domain containing 1".
Further reading
- Williams AJ, Blacklow SC, Collins T (Dec 1999). "The zinc finger-associated SCAN box is a conserved oligomerization domain". Molecular and Cellular Biology 19 (12): 8526–35. PMC 84969. PMID 10567577.
- Hartley JL, Temple GF, Brasch MA (Nov 2000). "DNA cloning using in vitro site-specific recombination". Genome Research 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
- Sander TL, Morris JF (Aug 2002). "Characterization of the SCAN box encoding RAZ1 gene: analysis of cDNA transcripts, expression, and cellular localization". Gene 296 (1-2): 53–64. doi:10.1016/S0378-1119(02)00792-8. PMID 12383503.
- Wiemann S, Arlt D, Huber W, Wellenreuther R, Schleeger S, Mehrle A, Bechtel S, Sauermann M, Korf U, Pepperkok R, Sültmann H, Poustka A (Oct 2004). "From ORFeome to biology: a functional genomics pipeline". Genome Research 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
- Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
- Mehrle A, Rosenfelder H, Schupp I, del Val C, Arlt D, Hahne F, Bechtel S, Simpson J, Hofmann O, Hide W, Glatting KH, Huber W, Pepperkok R, Poustka A, Wiemann S (Jan 2006). "The LIFEdb database in 2006". Nucleic Acids Research 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.
- Carneiro FR, Silva TC, Alves AC, Haline-Vaz T, Gozzo FC, Zanchin NI (Apr 2006). "Spectroscopic characterization of the tumor antigen NY-REN-21 and identification of heterodimer formation with SCAND1". Biochemical and Biophysical Research Communications 343 (1): 260–8. doi:10.1016/j.bbrc.2006.02.140. PMID 16540086.
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