Maleylacetoacetate isomerase

maleylacetoacetate isomerase
Identifiers
EC number 5.2.1.2
CAS number 9023-75-0
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum
Gene Ontology AmiGO / EGO

In enzymology, a maleylacetoacetate isomerase (EC 5.2.1.2) is an enzyme that catalyzes the chemical reaction

4-maleylacetoacetate \rightleftharpoons 4-fumarylacetoacetate

Hence, this enzyme has one substrate, 4-maleylacetoacetate, and one product, 4-fumarylacetoacetate.

This enzyme belongs to the family of isomerases, specifically cis-trans isomerases. The systematic name of this enzyme class is 4-maleylacetoacetate cis-trans-isomerase. Other names in common use include maleylacetoacetic isomerase, maleylacetone isomerase, and maleylacetone cis-trans-isomerase. This enzyme participates in tyrosine metabolism and styrene degradation.

Structural studies

As of late 2007, 3 structures have been solved for this class of enzymes, with PDB accession codes 1FW1, 2CZ2, and 2CZ3.

References

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