Malonyl-CoA O-methyltransferase

Malonyl-CoA O-methyltransferase (EC 2.1.1.197, BioC) is an enzyme with systematic name S-adenosyl-L-methionine:malonyl-CoA O-methyltransferase.^[1]^[2]^[3]^[4]^[5] This enzyme catalyses the following chemical reaction

S-adenosyl-L-methionine + malonyl-CoA

\rightleftharpoons

S-adenosyl-L-homocysteine + malonyl-CoA methyl ester

Malonyl-CoA O-methyltransferase is involved in an early step of biotin biosynthesis in Gram-negative bacteria.

References

↑ Del Campillo-Campbell, A., Kayajanian, G., Campbell, A. and Adhya, S. (1967). "Biotin-requiring mutants of Escherichia coli K-12". J. Bacteriol. 94 (6): 2065–2066. PMC 276941. PMID 4864413.
↑ Rolfe, B. and Eisenberg, M.A. (1968). "Genetic and biochemical analysis of the biotin loci of Escherichia coli K-12". J. Bacteriol. 96 (2): 515–524. PMC 252325. PMID 4877129.
↑ Otsuka, A.J., Buoncristiani, M.R., Howard, P.K., Flamm, J., Johnson, C., Yamamoto, R., Uchida, K., Cook, C., Ruppert, J. and Matsuzaki, J. (1988). "The Escherichia coli biotin biosynthetic enzyme sequences predicted from the nucleotide sequence of the bio operon". J. Biol. Chem. 263 (36): 19577–19585. PMID 3058702.
↑ Cleary, P.P. and Campbell, A. (1972). "Deletion and complementation analysis of biotin gene cluster of Escherichia coli". J. Bacteriol. 112 (2): 830–839. PMC 251493. PMID 4563978.
↑ Lin, S., Hanson, R.E. and Cronan, J.E. (2010). "Biotin synthesis begins by hijacking the fatty acid synthetic pathway". Nat. Chem. Biol. 6 (9): 682–8. doi:10.1038/nchembio.420. PMC 2925990. PMID 20693992.

External links

Malonyl-CoA O-methyltransferase at the US National Library of Medicine Medical Subject Headings (MeSH)

Transferase: one carbon transferases (EC 2.1)

2.1.1: Methyl-

N-	Histamine N-methyltransferase Phenylethanolamine N-methyltransferase Amine N-methyltransferase Phosphatidylethanolamine N-methyltransferase

O-	5-hydroxyindole-O-methyltransferase/Acetylserotonin O-methyltransferase Catechol-O-methyl transferase

Homocysteine	Betaine-homocysteine methyltransferase Homocysteine methyltransferase Methionine synthase

Other	Phosphatidyl ethanolamine methyltransferase DNMT3B Histone methyltransferase Thymidylate synthase DNA methyltransferase Thiopurine methyltransferase

2.1.2: Hydroxymethyl-,
Formyl- and Related

Hydroxymethyltransferase	Serine hydroxymethyltransferase 3-methyl-2-oxobutanoate hydroxymethyltransferase

Formyltransferase	Phosphoribosylglycinamide formyltransferase Inosine monophosphate synthase

Other	Glutamate formimidoyltransferase Aminomethyltransferase

2.1.3: Carboxy-
and Carbamoyl

Carboxy	methylmalonyl-CoA carboxytransferase

Carbamoyl	Aspartate carbamoyltransferase Ornithine carbamoyltransferase Oxamate carbamoyltransferase Putrescine carbamoyltransferase 3-hydroxymethylcephem carbamoyltransferase Lysine carbamoyltransferase N-acetylornithine carbamoyltransferase

2.1.4: Amidine

Arginine:glycine amidinotransferase

Enzymes

Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Catalytically perfect enzyme Coenzyme Cofactor Enzyme catalysis Enzyme kinetics Lineweaver–Burk plot Michaelis–Menten kinetics

Regulation	Allosteric regulation Cooperativity Enzyme inhibitor

Classification	EC number Enzyme superfamily Enzyme family List of enzymes

Types	EC1 Oxidoreductases(list) EC2 Transferases(list) EC3 Hydrolases(list) EC4 Lyases(list) EC5 Isomerases(list) EC6 Ligases(list)

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