Mesulfen

Mesulfen
Systematic (IUPAC) name

2,8-dimethylthianthrene
Clinical data
AHFS/Drugs.com	International Drug Names
Identifiers
CAS Number	135-58-0^Y
ATC code	D10AB05 (WHO) P03AA03 QP53AA01
PubChem	CID 67272
ChemSpider	580870
UNII	EG6V6W7WDD^Y
KEGG	D07212^Y
Chemical data
Formula	C₁₄H₁₂S₂
Molar mass	244.37508 g/mol
SMILES CC1=CC2=C(C=C1)SC3=C(S2)C=C(C=C3)C
InChI InChI=1S/C14H12S2/c1-9-3-5-11-13(7-9)15-12-6-4-10(2)8-14(12)16-11/h3-8H,1-2H3 Key:AHXDSVSZEZHDLV-UHFFFAOYSA-N
(verify)

Mesulfen is an anti-acne preparation^[1] as well as a scabicide.^[2] It is a dimethyl derivative of thianthrene.

References

↑ Leoni, A.; Dudine, G. (1983). "Therapy of seborrhea, seborrheic eczema and acne with a soap with a mesulfen base". Giornale italiano di dermatologia e venereologia : organo ufficiale, Societa italiana di dermatologia e sifilografia 118 (2): XXI–XXIV. PMID 6226594.
↑ Meneghini, C. L.; Vena, G. A.; Angelini, G. (1982). "Contact dermatitis to scabicides". Contact dermatitis 8 (4): 285–286. doi:10.1111/j.1600-0536.1982.tb04231.x. PMID 7105702.

Acne-treating agents (D10)

Antibacterial	Azelaic acid Benzoyl peroxide^# 8-Hydroxyquinoline Blue light therapy Tea tree oil

Keratolytic	Glycolic acid Salicylic acid^# Sulfur Benzoyl peroxide^#

Anti-inflammatory	Nicotinamide Ibuprofen # Aspirin # Red light therapy

Antibiotics	Clindamycin Dapsone Erythromycin Sulfacetamide Tetracyclines (Lymecycline Minocycline Doxycycline)

Hormonal	Antiandrogens Contraceptives

Retinoids	Adapalene Isotretinoin Motretinide Tazarotene Tretinoin

Other	Benzamycin Epristeride Mesulfen Pelretin Stridex Tioxolone

Combinations	Adapalene/benzoyl peroxide Benzoyl peroxide/clindamycin Clindamycin/tretinoin Erythromycin/isotretinoin Sulfacetamide/sulfur

^#WHO-EM ^‡Withdrawn from market Clinical trials: ^†Phase III ^§Never to phase III

Ectoparasiticides / arthropod (P03A)

Insecticide/pediculicide

Chlorine-containing products	Lindane

Chloride channel	Ivermectin

Organophosphate	Malathion

Acaricide/miticide/scabicide

Pyrethrines	Permethrin^# Pyrethrum Phenothrin Bioallethrin

Chloride channel	Ivermectin

Sulfur-containing products	Disulfiram Dixanthogen Mesulfen Thiram

Chlorine-containing products	Lindane

Benzoate	Benzyl benzoate^#

Organophosphate	Malathion

Other/ungrouped	Dimethicone Quassia toluidine (Crotamiton)

^#WHO-EM
^‡Withdrawn from market
Clinical trials:
- ^†Phase III
- ^§Never to phase III

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