Methanol—5-hydroxybenzimidazolylcobamide Co-methyltransferase

methanol-5-hydroxybenzimidazolylcobamide Co-methyltransferase
Identifiers
EC number	2.1.1.90
CAS number	86611-98-5
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / EGO
Search PMC articles PubMed articles NCBI proteins

In enzymology, a methanol-5-hydroxybenzimidazolylcobamide Co-methyltransferase (EC 2.1.1.90) is an enzyme that catalyzes the chemical reaction

methanol + 5-hydroxybenzimidazolylcobamide $\rightleftharpoons$ Co-methyl-Co-5-hydroxybenzimidazolylcob(I)amide + H₂O

Thus, the two substrates of this enzyme are methanol and 5-hydroxybenzimidazolylcobamide, whereas its two products are Co-methyl-Co-5-hydroxybenzimidazolylcob(I)amide and H₂O.

This enzyme belongs to the family of transferases, specifically those transferring one-carbon group methyltransferases. The systematic name of this enzyme class is methanol:5-hydroxybenzimidazolylcobamide Co-methyltransferase. Other names in common use include methanol cobalamin methyltransferase, methanol:5-hydroxybenzimidazolylcobamide methyltransferase, and MT 1.

Structural studies

As of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code 2I2X.

References

• Vogels GD; Te Brömmelstroet, BW; Poirot, CM; Van Der Drift, C; Vogels, GD (1984). "Purification and properties of methanol:5-hydroxybenzimidazolylcobamide methyltransferase from Methanosarcina barkeri". J. Bacteriol. 160 (2): 629–35. PMC 214781. PMID 6438059.