Methionine-S-oxide reductase
Methionine-S-oxide reductase (EC 1.8.4.5, methyl sulfoxide reductase I and II, acetylmethionine sulfoxide reductase, methionine sulfoxide reductase, L-methionine:oxidized-thioredoxin S-oxidoreductase) is an enzyme with systematic name L-methionine:thioredoxin-disulfide S-oxidoreductase.[1][2][3] This enzyme catalyses the following chemical reaction
- L-methionine + thioredoxin disulfide + H2O
L-methionine S-oxide + thioredoxin
In the reverse reaction, dithiothreitol can replace reduced thioredoxin.
References
- ↑ Black, S., Harte, E.M., Hudson, B. and Wartofsky, L. (1960). "A specific enzymatic reduction of L-(-)methionine sulfoxide and a related nonspecific reduction of diulfides". J. Biol. Chem. 235: 2910–2916.
- ↑ Ejiri, S.-I., Weissbach, H. and Brot, N. (1979). "Reduction of methionine sulfoxide to methionine by Escherichia coli". J. Bacteriol. 139 (1): 161–164. PMC 216841. PMID 37234.
- ↑ Ejiri, S.-I., Weissbach, H. and Brot, N. (1980). "The purification of methionine sulfoxide reductase from Escherichia coli". Anal. Biochem. 102: 393–398. doi:10.1016/0003-2697(80)90173-6. PMID 6999943.
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