Mitochondrial fission factor

Mitochondrial fission factor
Identifiers
Symbols	MFF ; C2orf33; GL004
External IDs	OMIM: 614785 MGI: 1922984 HomoloGene: 137341 GeneCards: MFF Gene
Gene ontology Molecular function • protein binding • protein homodimerization activity Cellular component • mitochondrial outer membrane • peroxisome • synaptic vesicle • cell junction • integral component of mitochondrial membrane Biological process • mitochondrial fission • release of cytochrome c from mitochondria • protein targeting to mitochondrion • mitochondrial fusion • regulation of mitochondrion organization • peroxisome fission • mitochondrial fragmentation involved in apoptotic process • protein homooligomerization • mitochondrion morphogenesis • positive regulation of mitochondrial fission • positive regulation of release of cytochrome c from mitochondria • positive regulation of protein targeting to membrane • regulation of peroxisome organization Sources: Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	56947	75734
Ensembl	ENSG00000168958	ENSMUSG00000026150
UniProt	Q9GZY8	Q6PCP5
RefSeq (mRNA)	NM_001277061	NM_029409
RefSeq (protein)	NP_001263990	NP_083685
Location (UCSC)	Chr 2: 227.33 – 227.36 Mb	Chr 1: 82.72 – 82.75 Mb
PubMed search

Mitochondrial fission factor (Mff) is a protein that in humans is encoded by the MFF gene.^[1]

Mff is an outer mitochondrial membrane protein that binds to the Drp1 GTPase that controls mitochondrial fission. The Mff-Drp1 complex promotes mitochondrial fission.^[2] Mff also regulates peroxisome morphology.^[3]

References

1. "Entrez Gene: mitochondrial fission factor".
2. Otera H, Wang C, Cleland MM, Setoguchi K, Yokota S, Youle RJ, Mihara K (Dec 2010). "Mff is an essential factor for mitochondrial recruitment of Drp1 during mitochondrial fission in mammalian cells". The Journal of Cell Biology 191 (6): 1141–58. doi:10.1083/jcb.201007152. PMC 3002033. PMID 21149567.
3. Gandre-Babbe S, van der Bliek AM (Jun 2008). "The novel tail-anchored membrane protein Mff controls mitochondrial and peroxisomal fission in mammalian cells". Molecular Biology of the Cell 19 (6): 2402–12. doi:10.1091/mbc.E07-12-1287. PMC 2397315. PMID 18353969.

Further reading

• Igci YZ, Arslan A, Akarsu E, Erkilic S, Igci M, Oztuzcu S, Cengiz B, Gogebakan B, Cakmak EA, Demiryurek AT (Jun 2011). "Differential expression of a set of genes in follicular and classic variants of papillary thyroid carcinoma". Endocrine Pathology 22 (2): 86–96. doi:10.1007/s12022-011-9157-8. PMID 21509594.