Modified Maddrey's discriminant function

The modified Maddrey's discriminant function) was originally described by Maddrey and Boitnott[1] to predict prognosis in alcoholic hepatitis. It is calculated by a simple formula:

(4.6 x (PT test - control))+ S.Bilirubin in mg/dl

Prospective studies have shown that it is useful in predicting short term prognosis especially mortality within 30 days.[2] A value more than 32 implies poor outcome with one month mortality ranging between 35% to 45%.[3]

To calculate Maddrey discriminant function using SI units - micromol/l (i.e. not US) divide bilirubin value by 17.

See also

Reference list

  1. ↑ Maddrey WC, Boitnott JK, Bedine MS, Weber FL, Mezey E, White RI (1978). "Corticosteroid therapy of alcoholic hepatitis". Gastroenterology 75 (2): 193–9. PMID 352788.
  2. ↑ Sheth M, Riggs M, Patel T (2002). "Utility of the Mayo End-Stage Liver Disease (MELD) score in assessing prognosis of patients with alcoholic hepatitis". BMC gastroenterology 2: 2. doi:10.1186/1471-230X-2-2. PMC 65516. PMID 11835693.
  3. ↑ Akriviadis E, Botla R, Briggs W, Han S, Reynolds T, Shakil O (2000). "Pentoxifylline improves short-term survival in severe acute alcoholic hepatitis: a double-blind, placebo-controlled trial". Gastroenterology 119 (6): 1637–48. doi:10.1053/gast.2000.20189. PMID 11113085.


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