Molybdopterin synthase

Molybdopterin synthase
Identifiers
EC number	2.8.1.12
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Search PMC articles PubMed articles NCBI proteins

Molybdopterin synthase (EC 2.8.1.12, MPT synthase) is an enzyme required to synthesize molybdenum cofactor (MoCo) from precursor Z (now known as cyclic pyranopterin monophosphate).^[1][2] This enzyme catalyses the following chemical reaction

cyclic pyranopterin monophosphate + 2 [molybdopterin-synthase sulfur-carrier protein]-Gly-NH-CH₂-C(O)SH + H₂O $\rightleftharpoons$ molybdopterin + 2 molybdopterin-synthase sulfur-carrier protein

It is heterodimeric and coded for by the MOCS2 gene.^[3]

References

1. Daniels, J.N., Wuebbens, M.M., Rajagopalan, K.V. and Schindelin, H. (2008). "Crystal structure of a molybdopterin synthase-precursor Z complex: insight into its sulfur transfer mechanism and its role in molybdenum cofactor deficiency". Biochemistry 47: 615–626. doi:10.1021/bi701734g. PMID 18092812.
2. Wuebbens, M.M. and Rajagopalan, K.V. (2003). "Mechanistic and mutational studies of Escherichia coli molybdopterin synthase clarify the final step of molybdopterin biosynthesis". J. Biol. Chem. 278: 14523–14532. doi:10.1074/jbc.m300453200. PMID 12571226.
3. Sloan, J; Kinghorn, JR; Unkles, SE (1999). "The two subunits of human molybdopterin synthase: evidence for a bicistronic messenger RNA with overlapping reading frames". Nucleic Acids Research 27 (3): 854–8. doi:10.1093/nar/27.3.854. PMC 148257. PMID 9889283.