Monoamniotic twins

Various types of chorionicity and amniosity (how the baby's sac looks) in monozygotic (one egg/identical) twins as a result of when the blastocyst or embryo splits.

Monoamniotic twins are identical twins that share the same amniotic sac within their mother’s uterus.[1] Monoamniotic twins are always identical, always monochorionic and are usually termed Monoamniotic-Monochorionic ("MoMo") twins.[1] They also share the placenta, but have two separate umbilical cords. Monoamniotic twins develop when an embryo does not split until after formation of the amniotic sac,[1] at about 9-13 days after fertilization.[2] Monoamniotic triplets or other monoamniotic multiples[3] are possible, but extremely rare.[1] Other obscure possibilities include multiples sets where monoamniotic twins are part of a larger gestation such as triplets, quadruplets, or more.

Occurrence

Monoamniotic twins are rare, with an occurrence of 1 in 35,000 to 1 in 60,000 pregnancies,[1] corresponding to about 1% of twin pregnancies.[3]


Complications

The survival rate for monoamniotic twins has been shown to be as high as 81%[4] to 95%[5] in 2009 with aggressive fetal monitoring, although previously reported as being between 50%[1] to 60%.[3] Causes of mortality and morbidity include:

Diagnosis

Abdominal ultrasonography of monoamniotic twins at a gestational age of 15 weeks. There is no sign of any membrane between the fetuses. A coronal plane is shown of the twin at left, and a sagittal plane of parts of the upper thorax and head is shown of the twin at right.

Ultrasound is the only way to detect MoMo twins before birth.[3] It can show the lack of a membrane between the twins after a couple of weeks' gestation, when the membrane would be visible if present.[3]

Further ultrasounds with high resolution doppler imaging and non-stress tests help to assess the situation and identify potential cord problems.[3]

There is a correlation between having a single yolk sac and having a single amniotic sac.[1] However, it is difficult to detect the number of yolk sacs, because the yolk sac disappears during embryogenesis.[1]

Cord entanglement and compression generally progress slowly, allowing parents and medical caregivers to make decisions carefully.[3]

Treatment

Only a few treatments can give any improvements.

Sulindac has been used experimentally in some monoamniotic twins, lowering the amount of amniotic fluid and thereby inhibiting fetal movement. This is believed to lower the risk of cord entanglement and compression. However, the potential side effects of the drug have been insufficiently investigated.[1][3]

Regular and aggressive fetal monitoring is recommended for cases of monoamniotic twins to look for cord entanglement beginning after viability. Many women enter inpatient care, with continuous monitoring,[1] preferably in the care of a perinatologist, an obstetrician that specialises in high risk pregnancies.[3]

All monoamniotic twins are delivered prematurely by cesarean section, since the risk of cord entanglement and/or cord compression becomes too great in the third trimester. The cesarean is usually performed between 32 and 34 weeks.[3] Steroids may be administered to stimulate the babies' lung development[3] and decrease the risk of infant respiratory distress syndrome. Vaginal birth is not recommended as it can cause cord prolapse, with the first baby delivered pulling the placenta shared with the second baby being left inside.

See also

References

  1. 1 2 3 4 5 6 7 8 9 10 11 12 13 14 Pregnancy-Info -- > Monoamniotic Twins Retrieved on July 9, 2009
  2. Shulman, Lee S.; Vugt, John M. G. van (2006). Prenatal medicine. Washington, DC: Taylor & Francis. pp. Page 447. ISBN 0-8247-2844-0.
  3. 1 2 3 4 5 6 7 8 9 10 11 12 13 MoMo Twins; Monochorionic Monoamniotic Twins By Pamela Prindle Fierro, About.com. Retrieved on July 9, 2009
  4. Hack KE, Derks JB, Schaap AH, Lopriore E, Elias SG, Arabin B, et al. Perinatal Outcome of Monoamniotic Twin Pregnancies. Obstet Gynecol. 2009;113(2, Part 1):353-60 http://journals.lww.com/greenjournal/Abstract/2009/02000/Perinatal_Outcome_of_Monoamniotic_Twin_Pregnancies.17.aspx
  5. Baxi LV, Walsh CA. Monoamniotic twins in contemporary practice: a single-center study of perinatal outcomes. The Journal of Maternal-Fetal & Neonatal Medicine. 2009. http://www.informaworld.com/openurl?genre=article&issn=1476%2d7058&issue=preprint&spage=1&doi=10%2e1080%2f14767050903214590&date=2009&atitle=Monoamniotic%20twins%20in%20contemporary%20practice%3a%20a%20single%2dcenter%20study%20of%20perinatal%20outcomes&aulast=Baxi&aufirst=Laxmi&auinit=V%2e
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