Monoprenyl isoflavone epoxidase

monoprenyl isoflavone epoxidase
Identifiers
EC number	1.14.99.34
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / EGO
Search PMC articles PubMed articles NCBI proteins

In enzymology, a monoprenyl isoflavone epoxidase (EC 1.14.99.34) is an enzyme that catalyzes the chemical reaction

7-O-methylluteone + NADPH + H⁺ + O₂ $\rightleftharpoons$ dihydrofurano derivatives + NADP⁺ + H₂O

The 4 substrates of this enzyme are 7-O-methylluteone, NADPH, H⁺, and O₂, whereas its 3 products are dihydrofurano pyranoisoflavone derivative, NADP⁺, and H₂O.

This enzyme belongs to the family of oxidoreductases, specifically those acting on paired donors, with O2 as oxidant and incorporation or reduction of oxygen. The oxygen incorporated need not be derive from O miscellaneous. The systematic name of this enzyme class is 7-O-methylluteone,NADPH:O2 oxidoreductase. Other names in common use include monoprenyl isoflavone monooxygenase, and 7-O-methylluteone:O2 oxidoreductase.

References

• Tanaka M and Tahara S (1997). "FAD-dependent epoxidase as a key enzyme in fungal metabolism of prenylated flavonoids". Phytochemistry 46 (3): 433–439. doi:10.1016/S0031-9422(97)00322-1.