N,N'-diacetyllegionaminate synthase

N,N'-diacetyllegionaminate synthase
Identifiers
EC number	2.5.1.101
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Search PMC articles PubMed articles NCBI proteins

N,N'-diacetyllegionaminate synthase (EC 2.5.1.101, neuB (gene), legI (gene)) is an enzyme with systematic name phosphenolpyruvate:2,4-diacetamido-2,4,6-trideoxy-alpha-D-mannopyranose 1-(2-carboxy-2-oxoethyl)transferase.^[1][2] This enzyme catalyses the following chemical reaction

2,4-diacetamido-2,4,6-trideoxy-alpha-D-mannopyranose + phosphenolpyruvate + H₂O $\rightleftharpoons$ N,N'-diacetyllegionaminate + phosphate

This enzyme requires a divalent metal such as Mn²⁺.

References

1. Glaze, P.A., Watson, D.C., Young, N.M. and Tanner, M.E. (2008). "Biosynthesis of CMP-N,N′-diacetyllegionaminic acid from UDP-N,N′-diacetylbacillosamine in Legionella pneumophila". Biochemistry 47 (10): 3272–3282. doi:10.1021/bi702364s. PMID 18275154.
2. Schoenhofen, I.C., Vinogradov, E., Whitfield, D.M., Brisson, J.R. and Logan, S.M. (2009). "The CMP-legionaminic acid pathway in Campylobacter: biosynthesis involving novel GDP-linked precursors". Glycobiology 19 (7): 715–725. doi:10.1093/glycob/cwp039. PMID 19282391.

External links

• N,N'-diacetyllegionaminate synthase at the US National Library of Medicine Medical Subject Headings (MeSH)